非处方药模糊综合评判模型的研究与设计

首先介绍了建立网上非处方药的评判系统是现代医疗手段发展的必然趋势,然后分别介绍了单级和多级Fuzzy综合评判的数学模型,最后提出了非处方药的评判体系及评判模型     

浅谈国有制药企业如何适应药品分类管理制度的改革

20 0 0年 1月 1日正式实施按照国际通用惯例实行的药品分类管理制度 ,将对我国制药业的发展战略、产品结构及营销方式带来较大影响。目前举步维艰的国有制药业应结合国情 ,针对自身特点 ,调整战略 ,扬长避短 ,找准主攻方向 ;重视开发 ,抢占国内外市场 ;树立品牌 ,加大宣传力度及加强营销、提高经营服务水平 ,积极参与竞争并力争在这场高水平的竞争中成为赢家 ,从而为企业发展打开新局面。     

从金融中介学的视角看场外交易市场的功能和作用

场外交易市场作为一种金融中介组织,可以有效解决我国中小企业融资难的问题。从金融中介学的视角分析了场外交易市场的功能和作用。     

Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines

The urea cycle (UC) removes the excess nitrogen and ammonia generated by nitrogen-containing compound composites or protein breakdown in the human body. Research has shown that changes in UC enzymes are not only related to tumorigenesis and tumor development but also associated with poor survival in hepatocellular, breast, and colorectal cancers (CRC), etc. Cytoplasmic ornithine, the intermediate product of the urea cycle, is a specific substrate for ornithine decarboxylase (ODC, also known as ODC1) for the production of putrescine and is required for tumor growth. Polyamines (spermidine, spermine, and their precursor putrescine) play central roles in more than half of the steps of colorectal tumorigenesis. Given the close connection between polyamines and cancer, the regulation of polyamine metabolic pathways has attracted attention regarding the mechanisms of action of chemical drugs used to prevent CRC, as the drug most widely used for treating type 2 diabetes (T2D), metformin (Met) exhibits antitumor activity against a variety of cancer cells, with a vaguely defined mechanism. In addition, the influence of metformin on the UC and putrescine generation in colorectal cancer has remained unclear. In our study, we investigated the effect of metformin on the UC and putrescine generation of CRC in vivo and in vitro and elucidated the underlying mechanisms. In nude mice bearing HCT116 tumor xenografts, the administration of metformin inhibited tumor growth without affecting body weight. In addition, metformin treatment increased the expression of monophosphate (AMP)-activated protein kinase (AMPK) and p53 in both HCT116 xenografts and colorectal cancer cell lines and decreased the expression of the urea cycle enzymes, including carbamoyl phosphate synthase 1 (CPS1), arginase 1 (ARG1), ornithine trans-carbamylase (OTC), and ODC. The putrescine levels in both HCT116 xenografts and HCT116 cells decreased after metformin treatment. These results demonstrate that metformin inhibited CRC cell proliferation via activating AMPK/p53 and that there was an association between metformin, urea cycle inhibition and a reduction in putrescine generation.     

新三板企业审计质量与融资效率:声誉视角分析

以新三板企业为研究对象,以会计事务所声誉为视角,建立回归模型,论证会计师事务所审计质量与企业融资效率之间的相关性,结果表明:定增规模较小的企业其融资额度与企业是否由排名前五的事务所审计之间的关系在统计上不显著,定增规模较大的企业其融资额度与企业是否由前五会计事务所审计正相关,并在统计上显著.此外,企业融资额度与企业规模之间的相关性在统计上显著,企业规模越大,企业融资越高,该模型系数在统计上显著;企业融资额度与资产负债率、企业盈利能力之间的相关性在统计上显著,资产负债率越高、企业盈利能力越强,企业融资效率越低,该模型系数在统计上越显著.要提高企业融资效率,应保证财务信息审计质量,注重会计师事务所声誉,促进新三板市场会计信息有效传递.     

气泡富集-高效液相色谱法测定地表水样中微量土霉素

建立了气泡富集-高效液相色谱（HPLC）测定地表水样中微量土霉素的方法。采用新型样品前处理方法--气泡富集法,对水溶液中的微量土霉素进行富集,考察了气泡富集条件对富集效果的影响。研究发现,在优化的气泡富集和色谱条件下,土霉素的富集倍数可达37.06,土霉素含量测定的RSD为4.8%（n=11）,LOD为0.038 mg/L。将该方法用于地表水样中土霉素的测定,平均加标回收率为101.9%。可见,气泡富集法对土霉素的富集效果好,能与色谱结合用于地表水样中土霉素的快速、灵敏、准确检测。同时,在进行样品前处理时无需任何有机溶剂,而且装置简单、成本低廉、易操作。可见气泡富集法是一种非常有研究和推广价值的绿色样品前处理方法,有望用于复杂样品中其他微量甚至痕量物质的分析。     

Development and Validation of an HPLC Method for Simultaneous Determination of Capsaicinoids and Camphor in Over-the-Counter Medication for Topical Use

A reverse-phase high-performance liquid chromatography method was developed to determine and quantify capsaicin (trans-8-methyl-N-vanillyl-6- nonenamid), dihydrocapsaicin (8-methyl-N-vanillylnonanamide), and camphor (trimethylbicyclo[2.2.1]heptan-2-one). It is applicable in analyses of over-the-counter (OTC) medications for topical use and raw materials such as chili pepper oleoresin. Chromatographic separation was carried out on a C18 column using an isocratic flow of the mobile phase containing acetonitrile and ultrapure water in a ratio of 2:3, with pH adjusted to 3.2 using glacial acetic acid, and a flow rate of 1.5 mL/min. The concentration of the eluting compounds was monitored by a diode-array detector at a wavelength of 281 nm. The method was evaluated for several validation parameters, including selectivity, accuracy (confidence intervals < 0.05%), repeatability, and intermediate precision. The limit of detection (LOD) was determined to be 0.070 µg/mL for capsaicin, 0.211 µg/mL for dihydrocapsaicin, and 0.060 µg/mL for camphor. The limit of quantification (LOQ) was determined to be 0.212 µg/mL for capsaicin, 0.640 µg/mL for dihydrocapsaicin, and 0.320 µg/mL for camphor. Linearity was set in the range of 2.5–200 µg/mL for capsaicin and dihydrocapsaicin and 25–2000 µg/mL for camphor. The suggested analytical method can be used for quality control of formulated pharmaceutical products containing capsaicinoids, camphor, and propolis.     

水中痕量土霉素的亲水溶剂浮选-分光光度测定

本文利用自制的浮选装置,选择四氢呋喃和无水乙醇(4+1)混合溶液作溶剂,氯化钠作分相剂,将Fe(Ⅲ)与土霉素(OTC)形成的疏水性缔合物浮选至有机相,然后采用分光光度法测定,方法线性线性范围为6.6×10~(-7)～3.4×10~(-5) mol/L;检出限为3.63×10~(-7) mol/L;平均回收率为99.95%;表观摩尔吸光系数ε=2.028×10~5 L·5moL~(-1)·5cm~(-1).该方法设备简单、测定快速、灵敏度高、分离物质易于提取和不产生二次污染,可用于环境水样中痕量土霉素的快速测定.     

基于模糊推理的OTC网上智能咨询系统的设计

以模糊推理的数学理论及数学模型为基础,建立基于模糊推理的OTC网上智能咨询系统的推理模型,通过实例对此推理模型进行分析验证.提出影响模糊推理准确性的关键问题在于隶属函数的选择及模糊矩阵的确定.     

药品分类管理制度对医院药剂科的影响

目的：阐述药品分类管理制度对医院药剂科的影响。方法：对国内文献资料进行归纳、分析和总结。结果：药品分类管理制度实施将对我国县级以上医院的药剂科产生重大影响。结论：实施药品分类管理制度，可促使医院药剂科由传统的以药品为中心的“保障供给型”向以病人为中心的“技术服务型”模式转化，有利于医院药剂科的发展。