全文获取类型
收费全文 | 2800篇 |
免费 | 146篇 |
国内免费 | 102篇 |
专业分类
化学 | 1199篇 |
晶体学 | 2篇 |
力学 | 91篇 |
综合类 | 26篇 |
数学 | 77篇 |
物理学 | 311篇 |
综合类 | 1342篇 |
出版年
2024年 | 4篇 |
2023年 | 21篇 |
2022年 | 85篇 |
2021年 | 87篇 |
2020年 | 71篇 |
2019年 | 56篇 |
2018年 | 60篇 |
2017年 | 55篇 |
2016年 | 77篇 |
2015年 | 100篇 |
2014年 | 124篇 |
2013年 | 141篇 |
2012年 | 173篇 |
2011年 | 124篇 |
2010年 | 106篇 |
2009年 | 132篇 |
2008年 | 129篇 |
2007年 | 142篇 |
2006年 | 127篇 |
2005年 | 140篇 |
2004年 | 117篇 |
2003年 | 137篇 |
2002年 | 94篇 |
2001年 | 90篇 |
2000年 | 92篇 |
1999年 | 81篇 |
1998年 | 62篇 |
1997年 | 57篇 |
1996年 | 67篇 |
1995年 | 45篇 |
1994年 | 48篇 |
1993年 | 36篇 |
1992年 | 23篇 |
1991年 | 21篇 |
1990年 | 26篇 |
1989年 | 20篇 |
1988年 | 20篇 |
1987年 | 12篇 |
1986年 | 10篇 |
1985年 | 7篇 |
1984年 | 8篇 |
1983年 | 2篇 |
1982年 | 6篇 |
1981年 | 4篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1976年 | 5篇 |
1973年 | 1篇 |
排序方式: 共有3048条查询结果,搜索用时 140 毫秒
1.
Herein, we report an addition to the toolbox for the monitoring and quantification of the hydrolytic decay of pentose-1-phosphates, which are known to be elusive and difficult to quantify. This communication describes how apparent equilibrium shifts of a nucleoside phosphorolysis reaction can be employed to calculate hydrolytic loss of pentose-1-phosphates based on the measurement of post-hydrolysis equilibrium concentrations of a nucleoside and a nucleobase. To demonstrate this approach, we assessed the stability of the relatively stable ribose-1-phosphate at 98 °C and found half-lives of 1.8–11.7 h depending on the medium pH. This approach can be extended to other sugar phosphates and related reaction systems to quantify the stability of UV-inactive and hard-to-detect reaction products and intermediates. 相似文献
2.
Yongjie Zhou Yuqi Mei Tian Luo Wenxue Chen Qiuping Zhong Haiming Chen Weijun Chen 《Molecules (Basel, Switzerland)》2021,26(9)
The contribution of rheological properties and viscoelasticity of the interfacial adsorbed layer to the emulsification mechanism of enzymatic modified sugar beet pectin (SBP) was studied. The component content of each enzymatic modified pectin was lower than that of untreated SBP. Protein and ferulic acid decreased from 5.52% and 1.08% to 0.54% and 0.13%, respectively, resulting in a decrease in thermal stability, apparent viscosity, and molecular weight (Mw). The dynamic interfacial rheological properties showed that the interfacial pressure and modulus (E) decreased significantly with the decrease of functional groups (especially proteins), which also led to the bimodal distribution of particle size. These results indicated that the superior emulsification property of SBP is mainly determined by proteins, followed by ferulic acid, and the existence of other functional groups also promotes the emulsification property of SBP. 相似文献
3.
Harsha K. Tripathy Nair S.V. Manju Sreekanth Dittakavi Ram Murthi Bestha Ramesh Mullangi 《Biomedical chromatography : BMC》2020,34(12):e4953
Larotrectinib is a first-generation tropomyosin kinase inhibitor, approved for the treatment of solid tumors. In this paper, we present a validated dried blood spot (DBS) method for the quantitation of larotrectinib from mouse blood using HPLC–MS/MS, which was operated under multiple reaction monitoring mode. To the DBS disc cards, acidified methanol enriched with internal standard (IS; enasidenib) was added and extracted using tert-butyl methyl ether as an extraction solvent with sonication. Chromatographic separation of larotrectinib and the IS was achieved on an Atlantis dC18 column using 10 mm ammonium formate–acetonitrile (30:70, v/v) delivered at a flow-rate of 0.80 ml/min. Under these optimized conditions, the retention times of larotrectinib and the IS were ~0.93 and 1.37 min, respectively. The total run time was 2.50 min. Larotrectinib and the IS were analyzed using positive ion scan mode and parent–daughter mass to charge ion (m/z) transitions of 429.1 → 342.1 and 474.1 → 267.1, respectively, were used for the quantitation. The calibration range was 1.06–5,080 ng/ml. No matrix effect or carryover was observed. Hematocrit did not influence DBS larotrectinib concentrations. All of the validation parameters met the acceptance criteria. The applicability of the validated method was shown in a mouse pharmacokinetic study. 相似文献
4.
Jonathan M. Levin Lawrence L. Wald Marc J. Kaufman Marjorie H. Ross Luis C. Maas Perry F. Renshaw 《Journal of magnetic resonance (San Diego, Calif. : 1997)》1998,130(2):292-295
Residual effects of an initial bolus of gadolinium contrast agent have been previously demonstrated in sequential dynamic susceptibility contrast MR experiments. While these residual effects quickly reach a saturation steady state, their etiology is uncertain, and they can lead to spurious estimates of hemodynamic parameters in activation experiments. The possible influence ofT1effects is now investigated with experiments in whichT1weighting is varied as well as with serial regionalT1measurements. Little evidence for significant residualT1effects is found, suggesting instead that susceptibility effects underlie these observations. An initial saturation dose of contrast agent minimizes this effect. 相似文献
5.
6.
Endoscopic Observation of Tissue by Narrowband Illumination 总被引:6,自引:0,他引:6
Kazuhiro Gono Kenji Yamazaki Nobuyuki Doguchi Tetsuo Nonami Takashi Obi Masahiro Yamaguchi Nagaaki Ohyama Hirohisa Machida Yasushi Sano Shigeaki Yoshida Yasuo Hamamoto Takao Endo 《Optical Review》2003,10(4):211-215
We propose a new illumination method for a medical endoscope: narrow band imaging (NBI), in which the spectral bandwidth of the filtered light is narrowed. To confirm how the spectral specifications of the filtered light influence a reproduced image, an experiment was conducted observing the endoscopic images of the back mucosa of a human tongue. In addition, the effect of NBI on endoscopic images was investigated through preliminary clinical tests in colonoscopy and upper gastrointestinal endoscopy. It has been shown that NBI can enhance the capillary pattern and the crypt pattern on the mucosa. These patterns are useful features for diagnosing an early cancer. 相似文献
7.
用血管铸型和透明方法观察了家兔膀胱的血供情况。膀胱动脉主要起自脐动脉,沿膀胱侧缘行向膀胱顶,沿途发出1~4支基本对称的分支分布于膀胱前面,两侧膀胱动脉的分支在其表面有吻合现象。膀胱动脉及其分支均呈不同程度的弯曲或弹簧状,可能是适应膀胱生理性增大的结构基础。 相似文献
8.
A palladium‐TPPTS catalyst heterogenized on KF/alumina has been shown to be effective and recyclable for the selective formation of monooctadienylxylopyranosides via the telomerization of butadiene with D ‐xylose. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
9.
10.
统计分析在血铅检测中的应用 总被引:1,自引:0,他引:1
该文针对河海大学幼儿园接受血铅调测的337名幼儿,以对家长问卷调查的方式,运用方差分析、假设检验及区间估计的方法对这些幼儿的血铅超标情况进行了统计分析.结果表明,虽然各年级幼儿血铅浓度无显著差异,但是大、中班幼儿(4~6岁)由于受环境铅污染机会多于小班幼儿和托班幼儿,故血铅超标率稍高;幼儿经常挑食、外出方式以助力车或摩托车为主、家长经常吸烟、家长职业性接触铅及其化合物等是血铅浓度超标的主要因素. 相似文献