Atlas of Fluorescence Spectra and Lifetimes of Dyes Attached to Protein

Abstract

Fluorescence spectra and lifetimes of ovalbumin labeled with a variety of fluorescent reagents have been measured. The peak positions of the emission spectrum and the long wavelength band of the excitation spectrum as well as the fluorescence lifetimes, are tabulated. Heterogeneity of binding sites is shown by the broadness of some emisison spectra and the presence of multiexponential decay. The atlas may serve as a guide to the properties of these dyes attached to proteins in general.     

A graph-based multi-sample test for identifying pathways associated with cancer progression

Cancer is in general not a result of an abnormality of a single gene but a consequence of changes in many genes, it is therefore of great importance to understand the roles of different oncogenic and tumor suppressor pathways in tumorigenesis. In recent years, there have been many computational models developed to study the genetic alterations of different pathways in the evolutionary process of cancer. However, most of the methods are knowledge-based enrichment analyses and inflexible to analyze user-defined pathways or gene sets. In this paper, we develop a nonparametric and data-driven approach to testing for the dynamic changes of pathways over the cancer progression. Our method is based on an expansion and refinement of the pathway being studied, followed by a graph-based multivariate test, which is very easy to implement in practice. The new test is applied to the rich Cancer Genome Atlas data to study the (epi)genetic alterations of 186 KEGG pathways in the development of serous ovarian cancer. To make use of the comprehensive data, we incorporate three data types in the analysis representing gene expression level, copy number and DNA methylation level. Our analysis suggests a list of nine pathways that are closely associated with serous ovarian cancer progression, including cell cycle, ERBB, JAK-STAT signaling and p53 signaling pathways. By pairwise tests, we found that most of the identified pathways contribute only to a particular transition step. For instance, the cell cycle and ERBB pathways play key roles in the early-stage transition, while the ECM receptor and apoptosis pathways contribute to the progression from stage III to stage IV. The proposed computational pipeline is powerful in detecting important pathways and gene sets that drive cancers at certain stage(s). It offers new insights into the understanding of molecular mechanism of cancer initiation and progression.     

海洋渔业服务电子图集创作与阅读系统

以国家海洋863课题《海洋渔业服务地理信息系统(OFGIS)》的基础支撑软件(EA2000)为基础，系统阐述了海洋渔业服务电子图集的组织结构、基本图层的分类与创作原理、海图图集阅读的专业功能与特色，并据此创建了以东海为示范区的海洋渔业服务电子图集。     

Framed! Reproducing and Revisiting 150-Year-Old Charts

The Statistical Atlases published by the Census Bureau in the late 1800s utilized a number of novel methods for displaying data. In this paper, we examine the use of framed spine and mosaic plots used in two plates of the Statistical Atlas of 1870. We use forensic statistics to recreate the data using available census information, and then use that data to create framed charts using modern plotting methods. We then examine the effectiveness of the framed charts compared to other alternatives with a user study. The data and code for this study are available online.     

中国地理课程系统工程建设与展望

中国地理课程是贯串于基础教育与高校地理专业教育的核心课程之一,它承担着地理国情教育的重任。因此,系统建设该课程不仅是国家的需求,而且对提高教学质量至关重要。全国高校中国地理教学研究会自1995年以来,通过多所高校联合攻关,在教学研究的基础上,从多媒体和多尺度两个视角,构建了中国地理课程六个系统工程,分别是中国地理系列教参（教科书、光盘）、《中国地理图集》、中国地理课程网站、中国地理网上课堂、《中国省市区地理》丛书、《中美地理比较》。这些工程将在“十二五”期间,继续延伸和实现优质资源的共享。     

平头蜗尾船的阻力系列试验及EHP估算方法

本文根据平头蜗尾船型系列试验的结果,利用逐步回归分析法给出了剩余阻力系数和湿表面积系数回归公式,编制了可供设计平头蜗尾船型估算有效马力EHP的阻力图谱及相应的湿面积系数图谱,图谱适用范围:L/T=26～34;B/T=4～6;C_B=0.54～0.66.     

A normalized thoracic coordinate system for atlas mapping in 3D CT images

In this paper, a normalized thoracic coordinate system （NTCS） is defined for rapidly mapping the 4D thoracic organ atlas into indi- vidual CT volume images. This coordinate system is defined based on the thoracic skeleton. The coordinate values are normalized by the size of the individual thorax so that this coordinate system is universal to different individuals. For compensating the respiratory motion of the organs, a 4D dynamic torso atlas is introduced. A method for mapping this dynamic atlas into the individual image using the NTCS is also proposed. With this method, the dynamic atlas was mapped into the clinical thoracic CT images and rough positions of the organs were found rapidly. This NTCS-based 4D atlas mapping method may provide a novel way for estimating the thoracic organ positions in low-resolution molecular imaging modalities, as well as in modern 4D medical images.     

A normalized thoracic coordinate system for atlas mapping in 3D CT images

In this paper, a normalized thoracic coordinate system (NTCS) is defined for rapidly mapping the 4D thoracic organ atlas into individual CT volume images. This coordinate system is defined based on the thoracic skeleton. The coordinate values are normalized by the size of the individual thorax so that this coordinate system is universal to di?erent individuals. For compensating the respiratory motion of the organs, a 4D dynamic torso atlas is introduced. A method for mapping this dynamic atlas into the individual image using the NTCS is also proposed. With this method, the dynamic atlas was mapped into the clinical thoracic CT images and rough positions of the organs were found rapidly. This NTCS-based 4D atlas mapping method may provide a novel way for estimating the thoracic organ positions in low-resolution molecular imaging modalities, as well as in modern 4D medical images.     

《城市运动会地图集》的设计与编制

为了服务城运,宣传江西、展示南昌,作为第七届城市运动会承办地,编制了《中华人民共和国第七届城市运动会地图集》。该图集充分利用了数字测绘产品和现代制图理论,以多种形式诠释了城市运动会专题信息和承办地风土人情,对该图集的设计思想与编制特点作了详细说明。