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1.
射干有效成分抗病毒主要药效学实验研究 总被引:1,自引:0,他引:1
目的观察射干不同有效成分体外抗病毒药效学作用。方法采用组织细胞培养法,观察射干有效成分对
呼吸道合胞病毒(RSV)、腺病毒3型(adv-3)、腺病毒7型(adv-7)、疱疹I(HSV-1)、疱疹Ⅱ(HSV-2)、鼻病毒-3
型、柯萨奇16(EV-16)等7种病毒的对抗作用。结果体外抗病毒试验结果显示,除1号、5号外,射干不同有效成
分无毒界限药液,对不同病毒RSV、AdV-3、AdV-7、HSV-I、HSV-2、EV-16、鼻病毒等具有一定抑制病毒致细胞病变
的作用。结论除1号、5号外,射干各有效成分分别对RSV、AdV-3、AdV-7、HSV-I、HSV-2、鼻病毒、EV-16等具有
不同程度的对抗作用。 相似文献
2.
We designed two aromatic analogues 1a and 1b of macrolactin A with expectation of enhancing biological activity and metabolical stability. As a result of retrosynthetic analysis of these compounds 1a-b, two synthetic strategies have been examined. The first strategy includes the enantioselective addition of nonadienyl anion, derived from 3, to aldehyde 4 as a key step. The second one includes epimerization of ynone 7 to (E,E)-conjugated dienone 31 and subsequent diastereoselective hydride-reduction of 31. Although the former route furnished no desired target, the latter one was revealed to work well for the synthesis of 1. Unfortunately, the aimed (2Z,4E)-analogue 1a could not be synthesized due to an epimerization of the (2Z)-olefin into the (2E)-olefin. However, these methods could be applied to the total asymmetric synthesis of the (2E,4E)-analogue 1b. Overall, control of all of the four stereocenters was achieved by means of asymmetric and diastereoselective reactions without using any chiral natural sources. 相似文献
3.
Wireless sensor networks (WSNs) have received extensive attention due to their great potential in civil and military applications. The sensor nodes have limited power and radio communication capabilities. As sensor nodes are resource constrained, they generally have weak defense capabilities and are attractive targets for software attacks. Cyber attack by worm presents one of the most dangerous threats to the security and integrity of the computer and WSN. In this paper, we study the attacking behavior of possible worms in WSN. Using compartmental epidemic model, we propose susceptible – exposed – infectious – recovered – susceptible with a vaccination compartment (SEIRS-V) to describe the dynamics of worm propagation with respect to time in WSN. The proposed model captures both the spatial and temporal dynamics of worms spread process. Reproduction number, equilibria, and their stability are also found. If reproduction number is less than one, the infected fraction of the sensor nodes disappears and if the reproduction number is greater than one, the infected fraction persists and the feasible region is asymptotically stable region for the endemic equilibrium state. Numerical methods are employed to solve and simulate the systems of equations developed and also to validate our model. A critical analysis of vaccination class with respect to susceptible class and infectious class has been made for a positive impact of increasing security measures on worm propagation in WSN. 相似文献
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5.
New pyrimidine nucleoside derivatives with nitric oxide(NO) donor were systematically synthesized.The antivirus activities of these nucleoside analogues against vesicular stomatitis virus(VSV) in Wish cell were evaluated.It was demonstrated that most of compounds had stronger antiviral acitivity than acyclovir,while their toxicities were similar or lower to acyclovir. 相似文献
6.
报道了一条合成丁烷木脂素的新路线. 以芳香醛为起始原料, Stobbe缩合和烷基化反应为关键步骤, 构建了木脂素骨架, 再经拆分及还原, 可得到相应的苏式和赤式异构体. 经官能团转化得到5个丁烷木脂素和8个丁醚木脂素, 其中3个天然产物为首次合成. 对合成产物进行抗HIV病毒和和抗疱疹病毒活性研究, 部分化合物显示出较高的抗病毒活性, 而且骨架构型对活性影响较大. 相似文献
7.
A series of novel N-tert-butyl-N′-acyl-5-memyl-l,2,3-thiadiazole-4-carbohydrazides were designed and synthesized.Their structures were characterized by melting points,~1H NMR,IR,ESI-MS,and elemental analysis.The bioassay tests indicated that compound 7o exhibited excellent direct anti-TMV activity and induction activity in vivo at 50μg/mL,which was better than that of Ninamycin and tiadinial.Our studies indicated that 1,2,3-thiadiazole was an active substructure for novel pesticide development. 相似文献
8.
A series of 4H-[1,2,5]oxadiazolo[3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides was designed,synthesized and evaluated against vesicular stomatitis virus(VSV)in Wish cell.The antiviral activities of all compounds were stronger than those of acyclovir,while their toxicities were similar to those of acyclovir. 相似文献
9.
合成了一系列新型O-糖基-甲氧甲酰基膦酰胺酯,并对O-糖基亚磷酰胺酯与氯甲酸甲酯的Arbuzov反应及其它有关反应进行了讨论。产物的结构经1HNMR、31PNMR、IR及元素分析确定。初步的生物活性测定结果表明,化合物3e对人肝癌Bel-7402细胞和人白血病HL-60细胞有一定的抑制作用。化合物3a对烟草花叶病毒有一定的抑制活性。 相似文献
10.