主流防病毒软件深度研究与测试

分析四款主流防病毒软件的厂家背景,依托信息安全实验室搭建了测试环境,测试病毒查杀能力对比,测试系统资源占用情况对比,测试客户端与服务器端功能对比,总结四款防病毒软件的优劣对比,为企业选择防病毒病毒软件提供了基础数据。     

烟草企业信息网络系统安全架构的设计

随着信息化和经济全球化的发展,信息已成为社会发展的重要战略资源,网络成为不可或缺的基础设施,改变了传统工作模式,提高了工作效率,降低了企业运营成本。烟草企业目前建立了ERP、电子商务、内外部网站,办公自动化、企业电子邮件等应用系统,因此信息网络系统的安全尤为重要,必须对烟草企业安全问题进行深入分析研究,在整个企业建立完善的多层次的网络安全体系架构。本文立足于烟草企业信息网络系统安全架构的规划、设计,对信息网络系统方面存在的安全风险进行了深入分析,提出安全规划,明确建设目标。     

N－吡唑啉酮基－α－氨基膦酸酯的合成及其生物活性的研究

Ｎ－吡唑啉酮基－α－氨基膦酸酯的合成及其生物活性的研究龙韫先，张克胜，邱德文（南开大学元素有机化学研究所，天津，３０００７１）关键词氨基膦酸酯，合成，抗病毒活性植物病毒病素有“植物癌症”之称，每年因此造成经济损失多达上百亿美元。因此，国内外的科研工作...     

STING-activating drug delivery systems:Design strategies and biomedical applications

The stimulator of interferon genes(STING) shows promising clinical activity in infectious diseases and tumors.However,the lack of targeting capability and intracellular stability of STING agonists severely limits the therapeutic efficacy.Recently,drug delivery systems(DDSs) overcome these delivery barriers of STING agonists via passive or active cell targeting,prolonged blood circulation and drug release,and lysosome escape,etc.In this review,we will describe in detail how existing DDSs are designed to overcome delivery barriers and activate the STING pathway,and the current biomedical applications of STING-activating DDSs in the treatments of infectious diseases and tumors.Finally,the prospects and challenges of DDSs in STING activation are discussed.     

A novel computer virus model and its dynamics

In this paper, we propose a novel computer virus propagation model and study its dynamic behaviors; to our knowledge, this is the first time the effect of anti-virus ability has been taken into account in this way. In this context, we give the threshold for determining whether the virus dies out completely. Then, we study the existence of equilibria, and analyze their local and global asymptotic stability. Next, we find that, depending on the anti-virus ability, a backward bifurcation or a Hopf bifurcation may occur. Finally, we show that under appropriate conditions, bistable states may be around. Numerical results illustrate some typical phenomena that may occur in the virus propagation over computer network.     

网络环境下图书馆电子阅览室安全问题研究

网络环境下的图书馆电子阅览系统是一个比较复杂多变的系统,安全管理受到包括硬件因素、软件因素、人为因素和制度因素等多种因素的影响。电子图书阅览模式不仅能快速地为读者提供最新的图书资讯,更能拓宽读者的阅览面,使读者获得更为全面的阅览资源与接触途径。然而在方便快捷的同时,电子阅览室也如其他事物一样,具有不可避免的缺陷。电子网络环境的繁复性为电子阅览室的安全带来巨大的挑战。本文就我国目前网络环境下的图书馆电子阅览室安全问题做了初步的研究与探讨。     

磷酰胺酯前药策略及ProTide技术在抗病毒药物研发中的应用

Antiviral drug is a powerful weapon for humans to defeat the virus. The spread of 2019 novel coronavirus pneumonia (COVID-19) outbreak has a serious impact on the world. At the same time, it also makes people aware of the importance of antiviral drug development. This article reviews the application of the phosphoramidate prodrug strategy and the application of ProTide technology in the development of antiviral drugs. The synthesis methods of nucleoside-phosphoramidate prodrugs are introduced. The application of nucleoside-phosphoramidate in different antiviral drugs is also summarized. This review can provide a reference for the development of new antiviral drugs in the future.     

新型抗HIV-1蛋白GRFT的构建、表达及活性研究

根据已知的新型抗HIV-1蛋白GRFT基因氨基酸序列,推测其DNA编码序列,密码子优化及修饰后进行全基因化学合成,连接到原核表达载体pET28a（+）中,转化大肠杆菌BL21(DE3),IPTG诱导表达,获得目的蛋白. SDS-PAGE、Western Blot分析结果表明,目的蛋白得到良好表达并具有抗原活性;对表达条件进行优化,在最佳表达条件下,目的蛋白的表达量可占菌体总蛋白的55.84%;利用Ni2+-NTA柱亲和层析法进行目的蛋白的复性和纯化,凝胶成像系统扫描分析表明,纯度可达94.06%;运用Dot-ELISA法进行复性蛋白的抗原结合活性检测,结果显示,目的蛋白能够与HIV-1膜蛋白抗原特异性结合,初步证明所表达的重组蛋白具有良好的体外结合活性;基于制备的能够表达HIV-1 gp120基因的靶细胞模型,运用IFA法开展目的蛋白的细胞结合活性研究,结果显示,目的蛋白能够与靶细胞发生特异性反应,表明成功制备并获得了具有生物活性的新型抗HIV-1蛋白GRFT,为进一步研制新型抗HIV-1基因工程药物及其靶向治疗制剂奠定了坚实基础.     

计算机的病毒与防范

本文在对多种计算机病毒及其发展做了深入研究的基础上,针对国内外反病毒技术现状和网络病毒发展的新趋势,提出了一些应对措施。由于杀毒软件是对病毒进行击破的有效手段,而防火墙是阻止病毒传播的有效手段,所以笔者将二者有机的结合在一起,设计出一套初级的方案。