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Anju Singh Ritushree Kukreti Luciano Saso Shrikant Kukreti 《Molecules (Basel, Switzerland)》2022,27(3)
Oxidative stress (OS) is a metabolic dysfunction mediated by the imbalance between the biochemical processes leading to elevated production of reactive oxygen species (ROS) and the antioxidant defense system of the body. It has a ubiquitous role in the development of numerous noncommunicable maladies including cardiovascular diseases, cancers, neurodegenerative diseases, aging and respiratory diseases. Diseases associated with metabolic dysfunction may be influenced by changes in the redox balance. Lately, there has been increasing awareness and evidence that diabetes mellitus (DM), particularly type 2 diabetes, is significantly modulated by oxidative stress. DM is a state of impaired metabolism characterized by hyperglycemia, resulting from defects in insulin secretion or action, or both. ROS such as hydrogen peroxide and the superoxide anion introduce chemical changes virtually in all cellular components, causing deleterious effects on the islets of β-cells, in turn affecting insulin production. Under hyperglycemic conditions, various signaling pathways such as nuclear factor-κβ (NF-κβ) and protein kinase C (PKC) are also activated by ROS. All of these can be linked to a hindrance in insulin signaling pathways, leading to insulin resistance. Hyperglycemia-induced oxidative stress plays a substantial role in complications including diabetic nephropathy. DM patients are more prone to microvascular as well as atherosclerotic macrovascular diseases. This systemic disease affects most countries around the world, owing to population explosion, aging, urbanization, obesity, lifestyle, etc. However, some modulators, with their free radical scavenging properties, can play a prospective role in overcoming the debilitating effects of OS. This review is a modest approach to summarizing the basics and interlinkages of oxidative stress, its modulators and diabetes mellitus. It may add to the understanding of and insight into the pathophysiology of diabetes and the crucial role of antioxidants to weaken the complications and morbidity resulting from this chronic disease. 相似文献
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Today, the mobile phone industry witnesses important changes, shifting from a value chain to a burgeoning business ecosystem. This paper deals with the relationships that are at the very core of mobile OS ecosystems for IMTs (smartphones and PDA): Microsoft-OS, Symbian-OS, Palm-OS and RIM-OS over the period 1998–2006. Our study confirms that an ecosystem’s borders are unclear. More than half of our sample’ relationships are shared by at least two different ecosystems. The ecosystems we studied do not differ in terms of exclusive relationship which suggests that coopetitive strategies are particularly relevant in mobile platforms war. 相似文献
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本文首先介绍了LPC1343的硬件架构和UCOS-Ⅱ实时操作系统的特点,最后介绍了UCOS-Ⅱ在LPC1343上移植的方法和注意事项。 相似文献
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智能手机操作系统群雄并起 总被引:1,自引:0,他引:1
近年来,随着全球移动数据业务使用量的迅猛增长,智能手机销量不断攀升。代表不同市场阵营的智能手机操作系统竞争日益激烈。笔者在回顾市场上主流操作系统形成现今市场地位的历史原因同时,对其未来的发展机遇逐一作了分析,在此基础上,对未来智能手机操作系统的市场格局做出了预测。 相似文献
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分析了智能终端技术在矿用平台的可行性,并根据矿业生产的实际需求,提出了引进传统键盘输入技术作为输入系统的补充技术,替代无法在矿业环境使用的触摸屏技术,实现Android系统终端在矿业生产领域的引进,促进了以高速CPU、智能控制技术为代表的先进平台在矿业环境使用,逐步实现矿场设备的更新升级。 相似文献
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Two waves of technology are dramatically changing daily life: cloud computing and mobile phones. New cloud computing services such as webmail and content rich data search have emerged. However, in order to use these services, a mobile phone must be able to run new applications and handle high network bandwidth. Worldwide, about 3.45 billion mobile phones are low end phones;they have low bandwidth and cannot run new applications. Because of this technology gap, most mobile users are unable to experience cloud computing services with their thumbs. In this paper, a novel platform, Thumb-in-Cloud, is proposed to bridge this gap.Thumb-in-Cloud consists of two subsystems: Thumb-Machine and Thumb-Gateways. Thumb-Machine is a virtual machine built into a low end phone to enable it to run new applications. Thumb-Gateways can tailor cloud computing services by reformatting and compressing the service to fit the phone' s profile. 相似文献
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在以MC68360为核心的某型网络通信设备中,采用Am79C940作为网络接口。设计Am79C940和MC68360的接口硬件电路,使用MC68360的2个IDMA通道在中断控制方式下,分别从Am79C940收,发数据。通过建立中断服务例程和缓冲链表数据结构.设计实现了基于Nucleus操作系统的网络驱动程序。运行实测表明接口工作性能稳定可靠,满足实际应用要求。 相似文献