新型三联栓塞材料在肝血管瘤栓塞治疗中的应用

目的：探讨新型三联栓塞材料在肝血管瘤栓塞治疗中的应用价值。方法：对47例肝血管瘤病人通过超选择性肝动脉插管,应用平阳霉素、超液态碘油和生物微球embosphere组成的新型三联栓塞材料治疗肝血管瘤。观察治疗前和治疗后12月血管瘤的大小变化、临床症状及并发症的发生情况。结果47例病人中肿瘤缩小〉50%或消失者为28例,瘤体缩小30%50%者16例,肿体缩小〈30%者5例。结论新型三联栓塞材料治疗肝血管瘤安全有效,是理想的肝血管瘤介入于段。     

585nm脉冲染料激光复合平阳霉素治疗草莓状血管瘤的评价

探讨了血管机配合平阳霉素治疗婴幼儿草莓状血管瘤的效果。使用进口SPTL－1b血管机，设定能量8．0～9．1J／cm2，按寿氏法［1］注射PYM，治疗间隔4～8周。所有病人经三次治疗痊愈，仅二例留有表浅疤痕。结论：SPTL－1b复合PYM在婴幼儿草莓状血管瘤治疗上有较好的临床效果。     

Application of microdialysis to study the in vivo release of pingyangmycin from in situ gels in rabbits

Microdialysis was used together with HPLC to monitor the local concentration of pingyangmycin hydrochloride (PYM) after embolizing rabbit ear-veins with an injectable sustained release formulation, PYM-Zein/PYM-Zein-sucrose acetate isobutyrate (SAIB), in situ gel. The dialysis probe was perfused at 2 microL/min. The in vivo recovery was 46.6 3.1% (n = 4). The samples were injected directly into HPLC. PYM was detected using UV detector at 291 nm. Separation from other components in the dialysate was performed using a Discovery((R)) RP-Amide C(16) column within 12 min. The response for PYM in the dialysate was linear (r(2) > 0.996) over the range of 2.5-212 microg/mL. The limit of detection and limit of quantitation of PYM in the dialysate were 0.4 and 1.5 microg/mL, respectively. The results demonstrated that the in situ gel of PYM-Zein-SAIB could extend the release of PYM to 4 days. SAIB could significantly cut down the initial burst of PYM from the in situ gels (p < 0.05).