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Magnetic helical microrobots swimming at low Reynolds numbers have attracted much interest because of their great potentials for biomedical applications. However, to endow them with sophisticated function integration toward targeted disease treatment still remains a major challenge. Here, we proposed a novel strategy of using Spirulina scaffolds to fabricate biohybrid magnetic helical microrobot (BMHM) with enhanced photothermal performance to fight against cancer cells and pathogenic bacteria. For the first time, CuS nanodots were densely and uniformly loaded intracellularly inside Spirulina cells after permeabilization, and Fe3O4 nanoparticles were subsequently deposited on the cell walls for magnetization. The BMHMs could be actuated forward at a high velocity and flexibly steered under rotating magnetic fields. Rapid and great photothermal temperature raise with robust cycling stability was achieved under 808 nm near-infrared laser irradiation. The BMHMs showed good biocompatibility with minor toxicity to HeLa cancer cells and Escherichia coli bacteria. Moreover, significant photothermal performance was further verified via a series of experiments for anticancer therapy and bacteria killing. Because of the remarkable features and facile cost-effective fabrication, the BMHMs demonstrated great potentials as an integrated microrobot platform for future anticancer and antibacteria applications. 相似文献
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Akihiro Torii Toru Inoue Kae Doki Akiteru Ueda 《Electronics and Communications in Japan》2008,91(3):1-8
The error in a position measurement system for a microrobot is described. The system consists of position‐sensitive detectors and moving landmarks, which are lasers mounted on linear stages. The system requires accurate positioning of the linear stages. The position measurement accuracy was investigated by varying the angle formed by the linear stages. Under our experimental conditions, the maximum measurement error was about 0.2 mm, which was reduced to 5µm by using the method of least squares. © 2008 Wiley Periodicals, Inc. Electron Comm Jpn, 91(3): 1–8, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/ecj.10067 相似文献
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Immihan Ceren Yasa Ahmet Fatih Tabak Oncay Yasa Hakan Ceylan Metin Sitti 《Advanced functional materials》2019,29(17)
Poor retention rate, low targeting accuracy, and spontaneous transformation of stem cells present major clinical barriers to the success of therapies based on stem cell transplantation. To improve the clinical outcome, efforts should focus on the active delivery of stem cells to the target tissue site within a controlled environment, increasing survival, and fate for effective tissue regeneration. Here, a remotely steerable microrobotic cell transporter is presented with a biophysically and biochemically recapitulated stem cell niche for directing stem cells towards a pre‐destined cell lineage. The magnetically actuated double‐helical cell microtransporters of 76 µm length and 20 µm inner cavity diameter are 3D printed where biological and mechanical information regarding the stem cell niche are encoded at the single‐cell level. Cell‐loaded microtransporters are mobilized inside confined microchannels along computer‐controlled trajectories under rotating magnetic fields. The mesenchymal stem cells are shown retaining their differentiation capacities to commit to the osteogenic lineage when stimulated inside the microswimmers in vitro. Such a microrobotic approach has the potential to enable the development of active microcarriers with embedded functionalities for controlled and precisely localized therapeutic cell delivery. 相似文献
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Hongshuang Guo Tero-Petri Ruoko Hao Zeng Arri Priimagi 《Advanced functional materials》2024,34(10):2312068
Materials that undergo shape morphing in response to external stimuli have numerous applications, e.g., in soft robotics and biomedical devices. Shape memory polymers utilize kinetically trapped states to, typically irreversibly, transfer between a programmed morphed shape and an equilibrium shape. Liquid crystal elastomers (LCEs), in turn, can undergo reversible actuation in response to several stimuli. This study combines the irreversible and reversible shape morphing processes to obtain LCEs that undergo shape-programming via the shape memory effect and subsequent reversible actuation of the programmed shape. This is enabled by an LCE crosslinked via dynamic hydrogen bonds that break at high temperatures and reform upon cooling, endowing the shape memory effect, while mild thermal or photothermal stimulation yields the reversible actuation. Through this combination, proof-of-concept robotic application scenarios such as grippers that can adjust their shape for grabbing different-sized objects and crawling robots that can morph their shape to adapt to constrained spaces, are demonstrated. It is anticipated that this work adds new diversity to shape-programmable soft microrobotics. 相似文献
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随着微机器人的快速发展,对精密加工技术的要求日益提高。飞秒激光微纳加工技术凭借其高精度、高效率和非接触操作等优势,在微机器人领域展现出巨大的应用潜力。综述了激光微纳加工在微机器人领域的最新研究进展,重点围绕激光加工技术、材料选择与实际应用三个方面展开。在加工技术方面,激光微纳加工具有卓越的微细加工能力,实现了微机器人结构的精确制造;在材料选择上,选择了激光微纳加工微机器人的典型材料：光刻胶、金属材料和水凝胶;通过实例分析,展示了激光微纳加工微机器人的应用场景;在生物医疗方面包括靶向给药、细胞操纵和微创手术等,在工业方面包括精密器件精细加工和微物体检测等。最后对激光微纳加工微机器人进行总结与展望,为微机器人领域的发展提供了参考。 相似文献
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