Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Rupestonic acid, a potential anti‐influenza agent, is an important and characteristic compound in Artemisia rupestris L., a well‐known traditional Uighur medicine for the treatment of colds. In the present study, high‐performance liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry was used to detect and identify the metabolites in rat urine after oral administration of rupestonic acid. A total of 10 metabolites were identified or partially characterized. The structure elucidations of the metabolites were performed by comparing the changes in accurate molecular masses and fragment ions with those of the parent compound. The results showed that the main metabolites of rupestonic acid in rat urine were formed by oxidation, hydrogenation and glucuronidation. A metabolism pathway was proposed for the first time based on the characterized structures. This metabolism study can provide essential information for drug discovery, design and clinical application of rupestonic acid. Copyright © 2014 John Wiley & Sons, Ltd.     

基于mobile agent的分布式网络自管理模型

为了解决大规模、异构网络环境下基于“管理员密集”的传统网络管理模式带来的低效率和高出错率问题，提出了一种网络自管理模型，从网络管理的自动初始化和动态自管理两个方面实现对网络自动、自主、自适应的管理；提出了管理定位服务这一关键技术，在多个管理站协同工作的分布式网络环境中为设备自动定位出合适的管理站及初始的管理任务；采用可伸缩的分布式体系结构，适应了大规模网络的规模可变性等特点；基于mobile agent的管理框架进一步提高了管理的自适应性和灵活性。     

水溶性防氧化剂在SMT用印制板上的应用

水溶性的防氧化剂是一种有机可焊性保护剂。其方法是在印制板完全阻焊、字符层的印刷，并经电检之后，通过表面浸渍在裸铜的贴片位或通孔内形成一种耐热性的有机可焊性膜层。这种有机、可焊、耐热的膜层，膜厚可达0.3-0.5mm，其分解的温度可达约300℃，传统的印制板的热风整平法亦无法满足QFP愈来愈密集的需求，同时也无法满足SMD表面平整度的要求，更无法适应PCB薄型化生产。烷基苯并咪唑的OSP法能弥补这项缺陷，因而在PCB业乃至SMT产业中得到了广泛的应用。     

Synthesis and characterization of linear tetrablock quarterpolymers of styrene,isoprene, dimethylsiloxane,and 2-vinylpyridine

A series of five tetrablock quarterpolymers of styrene, isoprene, dimethylsiloxane, and 2-vinylpyridine with molecular weights varying from 117 × 10³ to 177 × 10³ and having different compositions were synthesized. The synthesis was based on recent advances in the controlled high-vacuum anionic polymerization of hexamethylcyclotrisiloxane and on the selective linking of poly(dimethylsiloxane)lithium with the chlorosilane group of the heterofunctional linking agent chloromethylphenylethylene dimethylchlorosilane. Combined characterization results by size exclusion chromatography, membrane osmometry, and NMR spectroscopy suggested that the synthesized multiblock multicomponent polymers had a high degree of structural and compositional homogeneity. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 514–519, 2004     

Synthesis And Properties Of Functional Ultra-High Molecular Weight Transparent Styrene-Butadiene Block Copolymer

Functional ultra-high molecular weight transparent styrene-butadiene block copolymer possesses both high transparency and impact resistance and has excellent comprehensive properties prior to other transparent resins. In this paper we not only use anionic polymerization process which includes 1 time addition of initiator and 3 time addition of monomers, but also introduce functional coupling agent for the fist time to prepare mentioned functional block copolymer. The typical preparation proces…     

红外化学遥感数字信号处理算法的研究进展

介绍了几种为远距离红外蒸汽信号监测开发的分类器设计，频域数字滤波，时域数字滤波等数字信号处理技术。对线性分类器，分段线性分类器和神经网络分类器等在红外化学遥感系统中的应用做了初步的探讨。对背景扣除技术，频域数字滤波技术，数字滤波的切趾方法等做了简要的描述。阐述了时域滤波技术的基本原理及实际应用。展望了红外化学遥感数字信号处理算法的研究前景。     

CORBA~( ):一个具有自卫智能体的扩展CORBA

将自卫机制加入OOP成为AOP以提高CORBA中软件的强健性和防卫能力,在CORBA这个异构环境中,一个对象申请服务之后就需等待,如果应答迟迟不到则有可能永远等待下去,为避免这种现象的产生和蔓延,在客户和服务方的行为中加入超时机制(timeout mecha-nism)并采用利己或利他策略,使得对象可独立地根据当前环境和时间决定下一步骤,将这种在协作者失败的情况下仍能生存的对象称为自卫智能体,加入白卫智能体的CORBA称为CORBA~( ),由于智能体可在任何条件下生存,CORBA~( )可为用户提供可靠的服务,也就能实现CORBA~( )中软件构成的强健性。     

Research and Design of Network Management Construction Based on Mobile AGENT

The technical characters of mobile agent （MA） originated in the distributional artificial intelligence domain is introduced. A network management construction based on agent （NMCA） is then proposed. The NMCA structure features are elaborated in detail. A prototype design of NMCA is given by using the jKQML programming. The establishment of NMCA platform will be helpful to reduce the correspondence load of network management and improves the efficiency and the expansion ability of network management systems.     

Novel radical‐responsive MRI contrast agent based on paramagnetic liposomes

A novel, radical responsive MRI contrast agent based on a gadolinium chelate conjugated to a liposome through a disulfide linker was synthesized, with the aim of pursuing the in vivo mapping of radicals. The liposome was prepared by incorporating a thiol‐activated phospholipid, which was subsequently reacted with a gadolinium chelate containing a free thiol group. The long reorientational motion of the supramolecular adduct endows the paramagnetic agent with a relaxivity significantly higher than that of the free complex. The disulfide bond represents a radical‐sensitive moiety and a large decrease in contrast efficacy (T₁ relaxivity) is shown upon its cleavage. A preliminary assessment of the system was made by means of in vitro gamma‐irradiation and thiol–disulfide bond exchange with dithiothreitol. Both methods showed a clear dose‐dependent decrease in T₁‐relaxivity. Copyright © 2003 John Wiley & Sons, Ltd.     

移动式数据挖掘平台模型

本文提出了一种移动式网络海量数据挖掘平台，给出了数据挖掘任务的形式化描述，详细讨论了平台的体系结构、工作原理与流程。该平台克服了传统网络计算模式的缺陷，支持对异质、分散数据源和知识源的挖掘和检索，具有开放性、可伸缩性、灵活性、可扩展性、健壮性。