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Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry
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Dongyu Gu Yi Yang Qibin Chen Madina Habasi Jiangyu Zhao Haji Akber Aisa 《Biomedical chromatography : BMC》2015,29(4):595-603
Rupestonic acid, a potential anti‐influenza agent, is an important and characteristic compound in Artemisia rupestris L., a well‐known traditional Uighur medicine for the treatment of colds. In the present study, high‐performance liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry was used to detect and identify the metabolites in rat urine after oral administration of rupestonic acid. A total of 10 metabolites were identified or partially characterized. The structure elucidations of the metabolites were performed by comparing the changes in accurate molecular masses and fragment ions with those of the parent compound. The results showed that the main metabolites of rupestonic acid in rat urine were formed by oxidation, hydrogenation and glucuronidation. A metabolism pathway was proposed for the first time based on the characterized structures. This metabolism study can provide essential information for drug discovery, design and clinical application of rupestonic acid. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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西咪替丁的应用进展 总被引:2,自引:0,他引:2
劳英 《宁波大学学报(理工版)》2002,15(2):89-92
综述了近年来国内外报道的H2受体抗拮剂-西咪替丁应用于除治疗消化性溃疡以外的其他疾病的进展情况,以其为临床用药提供参考。 相似文献
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The stereoselective synthesis of the two segments 3 and 4 of macrolactin A 1 is described. Macrolactin A is a 24-membered polyene macrolide antibiotic, which is of interest due to a strong activity against B16-F10 murine tumor cell and HIV-1 virus. The key step of the synthesis is the 1,2-migration reaction of a (diene)Fe(CO)3 complex with a introduction of the thiol group to construct the unstable (E,Z)-conjugated dienic moiety (C8-C11). 相似文献
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随着网络化应用程度的提高,能否有效防御网络病毒已决定着网络技术进一步应用的前景。本文介绍了网络各个环节上的病毒防御方式,并分析不同网络环境下防毒技术的选择。 相似文献
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多糖类免疫调节剂的研究和应用 总被引:56,自引:0,他引:56
本文综述了从自然界分离出来的多糖的研究进展、存在问题和应用前景。讨论了多糖的免疫调节特性和作用、多糖的结构与功能以及它们的应用。 相似文献
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Review on supermolecules as chemical drugs 总被引:3,自引:0,他引:3
ChengHe Zhou LinLing Gan YiYi Zhang FeiFei Zhang GuangZhou Wang Lei Jin RongXia Geng 《中国科学B辑(英文版)》2009,52(4):415-458
Supramolecular medicinal chemistry field has been a quite rapidly developing, increasingly active and newly rising interdiscipline
which is the new expansion of supramolecular chemistry in pharmaceutical sciences, and is gradually becoming a relatively
independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules
through non-covalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules
as chemical drugs, i.e. supramolecular chemical drugs or supramolecular drugs, which might have the excellences of lower cost,
shorter period, higher potential as clinical drugs for their successful research and development, may possess higher bioavailability,
better biocompatibility and drug-targeting, fewer multidrug-resistances, lower toxicity, less adverse effect, and better curative
effects as well as safety, and therefore exhibit wide potential application. These overwhelming advantages have drawn enormous
special attention. This paper gives the definition of supramolecular drugs, proposes the concept of supramolecular chemical
drugs, and systematically reviews the recent advances in the research and development of supermolecules, including organic
and inorganic complex ones as chemical drugs in the area of antitumor, anti-inflammatory, analgesic, antimalarial, antibacterial,
antifungal, antivirus, anti-epileptic, cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives
of the foreseeable future and potential application of supramolecules as chemical drugs are also presented.
Supported by the Southwest University (Grant Nos. SWUB2006018 & XSGX0602), the Natural Science Foundation of Chongqing (Grant
Nos. 2007BB5369 & 2006BB4341) and the Key Project from the Personnel Department of China (Grant No. 2002-99) 相似文献
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CrystalandMolecularStructureofN,N-Bis(2-chloroethyl)-N'-isopropyl-N"-phenylThioureidoPhosphoramideChenRu-Yu;WangHui-Lin;ZhouJ... 相似文献
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