Development of an LC‐MS/MS method for determining the pharmacokinetics of clonidine following oral administration of Zhenju antihypertensive compound

Zhenju antihypertensive compound (ZJAHC) is a combined Chinese–Western medicine formula including clonidine (CLO), hydrochlorothiazide (HCT), rutin, Chrysanthemum indicum extract and pearl powder. Compared with CLO preparations, ZJAHC shows improved activities and decreased adverse effects. It is believed that the side effects of CLO are caused by its high peak plasma concentration. Hence, study of the influence of ZJAHC on the pharmacokinetic behaviors of clonidine seems essential. In present study, the plasma concentrations of CLO were determined with a liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method. The MS/MS transitions monitored for clonidine and internal standard were 230.2 → 213.1 and 152.2 → 110.2, respectively. The analyte was quantified in a single run within 3 min. The pharmacokinetic study showed that the area under the plasma concentration–time curve of CLO in ZJAHC (60 µg/kg CLO) was similar to that of CLO‐HCT‐high (120 µg/kg CLO) but the peak concentration was much lower than that in CLO‐HCT‐high. ZJAHC could enhance the bioavailability without greatly increasing peak concentration of clonidine. This comprehensive effect of enhancing the bioavailability and avoiding the high peak plasma concentration for CLO might mainly result from the co‐contribution of Western medicine and traditional Chinese medicine (TCM), while the effect of TCM was stronger than that of Western medicine. Copyright © 2014 John Wiley & Sons, Ltd.     

嵌入式RISC核MPEG2/AC3解码器

介绍了在一个嵌入RISC核的AC3／MPEG2音／视频解码器中，通过增加特殊指令及其相应的硬件逻辑，对AC3的音频解码进行了一定的改进，不仅达到了AC3解码的实时性要求，而且降低了对存储器的要求。     

Sequential Decoding of Convolutional Codes for Rayleigh Fading Channels

The performance of sequential decoding of long constraint length convolutional codes is evaluated for Rayleigh fading channels. Sequential decoding is not practical below a certain theoretical signal-to-noise ratio, and these theoretical limits are calculated for a number of modulation methods and code rates. As an example, with BPSK modulation, soft decisions and code rate 1/2, the theoretical signal-to-noise ratio per information bit is 5.7 dB. Above this limit the bit error rate can be made arbitrarily small by increasing the constraint length at no significant complexity cost. Furthermore, it is shown that with carefully chosen quantization steps, 8 level uniform quantization gives a negligible loss also for sequential decoding on a Rayleigh fading channel. Simulation results using 8 level quantization correspond well with the theoretical performance bounds. Also, the performance on a correlated channel with finite interleaving has been obtained. With an interleaver depth of 50×50 and a normalized doppler frequency equal to 0.01 we are only 0.5 dB away from the performance with perfect interleaving. Finally, bit error rate results show this scheme to compete well with Turbo codes.     

MC-CDMA系统迭代检测中的一种信道估计算法

在DS—CDMA系统中，联合译码的迭代多用户检测是克服多址干扰增加系统容量的有效方法。本文将多用户检测和译码相结合的迭代检测技术应用于MC—CDMA系统，其中，多用户检测器由串行干扰消除和其后的MMSE滤波器组成。文中提出一种时域信道估计作为迭代初始值的频域信道估计算法，比单纯的频域信道估计方法节约导频符号数量，并且由于信道估计性能的改善，加快了迭代检测的收敛速度。     

一种改善Turbo乘积编码OFDM系统性能的新方法

本文提出一种利用对译码器软信息限幅来改善多径衰落信道中Turbo乘积编码OFDM(TPC-OFDM)系统性能的新方法。通过对不同多径衰落信道中QPSK映射和16QAM映射的TPC-OFDM系统性能的数值仿真，结果表明在10^-5误比特率下，这种新方法比传统的迭代译码大约有6～10dB的改进，对严重多径环境下TPC-OFDM系统的错误平底也有明显的改进。     

Turbo码概率-代数联合解码算法

Turbo码采用修正的BAHL et al.算法实现解码.这是一种基于软值的概率迭代解码算法.本文在保持Turbo码迭代软解码算法优点的基础上,充分利用Turbo码编码器结构这一确知条件,结合代数解码原理,提出了一种Turbo码概率-代数联合解码算法.该算法结合了概率解码和代数解码的优点,又有效避免了误差传播的发生,使Turbo码的纠错性能在原经典算法的基础上得到进一步的提高.该算法不仅为降低Turbo码的比特误码率和误差地板值提供了一种新的研究途径,而且因其更好的纠错性能而具有十分明显的实用价值.仿真实验结果显示,在比特误码率(BER)为10^-3~10^-4时,与经典Turbo码解码算法相比,采用该算法能获得0.1dB左右的编码增益.     

PERFORMANCE OF THREE STAGE TURBO－EQUALIZATION－DECODING

An increasing demand for high data rate transmission and protection over bandlimited channels with severe inter-symbol interference has resulted in a flurry of activity to improve channel equalization. In conjunction with equalization, channel coding-decoding can be employed to improve system performance. In this letter, the performance of the three stageturbo-equalization-decoding employing log maximum a posteriori probability is experimentally evaluated by a fading simulator. The BER is evaluated using various information sequence and interleaver sizes taking into account that the communication medium is a noisy inter symbol interference channel.     

线性分组码的神经网络译码

介绍了神经网络与线性分组码之间的关系，并在文献[1]的基础上证明了软判决译码与求解能量函数最大值之间的等价性，然后以(7，4，3)汉明码为例介绍了神经网络在循环码硬判决、软判决译码中的应用。     

On the complexity of suboptimal decoding for list and decision feedback schemes

We consider bounded distance list decoding, such that the decoder calculates the list of all codewords within a sphere around the received vector. We analyze the performance and the complexity of this suboptimum list decoding scheme for the binary symmetric channel. The reliability function of the list decoding scheme is equivalent to the sphere-packing bound, where the decoding complexity is asymptotically bounded by 2^nR(1-R). Furthermore, we investigate a decision feedback strategy that is based on bounded distance list decoding. Here, any output with zero or many codewords will call for a repeated transmission. In this case the decoding complexity will be of the order 2^nR(1-C), where C denotes the channel capacity. The reliability function is close to Forney's feedback exponent.     

一种数字解码卫星电视接收机的原理分析

分析了一种数字解码卫星电视接收机，该机能接收利用ＭＰＥＧ－２进行数据压缩，采用ＳＣＰＣ或ＭＣＰＣ方式上星的卫星电视信号，具有选单显示，断电现场保护等功能。并对该机进行了原理分析，对主要集成电路的基本原理也作了简介，并给出了软件的部分主要流程及功能分析。