We report on the fabrication of pH‐disintegrable polyelectrolyte multilayer‐coated mesoporous silica nanoparticles (MSN) capable of triggered co‐release of cisplatin and model drug molecules. The outer polyelectrolyte multilayer was assembled from permanently cationic polyelectrolyte, poly(allyl amine hydrochloride) (PAH), and negatively charged polyelectrolyte, P(DMA‐co‐TPAMA), consisting of N,N‐dimethylacrylamide (DMA) and 3,4,5,6‐tetrahydrophthalic anhydride‐functionalized N‐(3‐aminopropyl)methacrylamide (TPAMA) monomer units, which exhibits pH‐induced charge conversion characteristics. Thus, the subtle alteration of solution pH from 7.4 to ≈5–6 can lead to the disintegration of outer polyelectrolyte multilayers, accompanied with the co‐release of cisplatin and RhB.
We establish computationally flexible methods and algorithms for the analysis of multivariate skew normal models when missing values occur in the data. To facilitate the computation and simplify the theoretic derivation, two auxiliary permutation matrices are incorporated into the model for the determination of observed and missing components of each observation. Under missing at random mechanisms, we formulate an analytically simple ECM algorithm for calculating parameter estimation and retrieving each missing value with a single-valued imputation. Gibbs sampling is used to perform a Bayesian inference on model parameters and to create multiple imputations for missing values. The proposed methodologies are illustrated through a real data set and comparisons are made with those obtained from fitting the normal counterparts. 相似文献
Reversible addition-fragmentation chain transfer (RAFT) functionalities were anchored to the exterior surface of mesoporous silica nanoparticles (MSNs) without changing the mesoporous structure, RAFT polymerization of styrene was subsequently conducted to graft polystyrene (PSt) onto the exterior surface of MSNs, forming a novel core-shell nanostructure with a mesoporous core and a polymer nanoshell. Fourier transform infrared spectroscopy (FT-IR), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA) were used to characterize the produced mesoporous core-shell nanostructure, the results showed that the thickness of the nanoshell increased with the increasing time of polymerization. 相似文献
Energy is the determinant factor for the survival of Mobile Sensor Networks (MSN). Based on the analysis of the energy distribution in this paper, a two-phase relocation algorithm is proposed based on the balance between the energy provision and energy consumption distribution. Our main objectives are to maximize the coverage percentage and to minimize the total distance of node movements. This algorithm is designed to meet the requirement of non-uniform distribution network applications, to extend the lifetime of MSN and to simplify the design of the routing protocol. In addition, test results show the feasibility of our proposed relocation algorithm. 相似文献
In this letter, a novel algorithm is proposed for identification of one popular type of VoIP (Voice over IP) application, MSN VoIP, based on both behavior pattern and protocol characteristics. In addition, the experiment for validation is implemented. Since there exists no method identifying MSN VoIP session and furthermore the IP addresses, domain names, ports and even the protocols MSNP works over, are all alterable during the application, which makes it difficult to identify MSN VoIP session, this work will be helpful to advance the research on VoIP identification. 相似文献