元素平衡调节在医学中的应用

实验表明,摄钠过多引起的高血压,可通过增加钾摄入、减少钠摄入而使血压降低,钠钾比为1∶1时更有利于防止钠的升压作用。Keen的研究表明,饮料中含铁量在400×10-6以上时可减少幼鼠对锰的吸收。Nasoldin等对滑雪运动员的研究也证明,在人体内也存在这种影响,滑雪运动员在补铁后粪     

Preparation and Evaluation of Molecularly Imprinted Monolithic Column for Felodipine in Micro-liquid Chromatography

This study concentrated on the production of molecularly imprinted polymers (MIPs) as highly selective sorbents for felodipine (FLD), a representive dihydropyridine calcium antagonists. Demonstrated chromatographically through a selection factor, these MIPs showed high selectivity for the template molecule among a group of structurally similar compounds. The recognition was found to correlate with structural similarity to the template compound.     

微量元素与妊娠及围产医学的关系

为探讨微量元素与妊娠及围产医学的关系，取４９例正常孕产妇和５１例异常孕产妇的头发进行微量元素检测．结果表明，异常孕产妇中妊娠高血压综合征组发锌均值（１０４±１７．５４）×１０－６明显低于正常组（１６８±２２．１２）×１０－６，而发铜均值（１３．３±０．７８）×１０－６明显高于正常组（１１．３±０．９４）×１０－６，不明原因流产组发锌（１１５±１０．３２）×１０－６，发铜（９．０３±１．０３）×１０－６两项均值明显低于正常组，羊膜早破组仅发铜均值（７．５９±１．９７）×１０－６低于正常组；畸胎组则锌、铜、铁、钙均值都低于正常组．经统计学处理均有显著性差异（Ｐ＜０．０５或产＜０．０１）     

高血压类风湿症疗效与锌,钙关系初探

以临床典型病案为例，探讨了中医中药传统理论和现代微量元素研究的关系，重点讨论了向量元素锌、宏量元素钙与高血压、风湿症的病因病机和治疗关系。     

职业性铅接触对血压影响的研究

对１１８名铅接触工人及１０８名对照组工人的血压研究发现，在血铅为４４．２６μｇ／ｄＬ时，铅接触工人的收缩压显著高于对照组，分组研究发现，收缩压在级组剂量－反应关系趋势，在血铅３０．２０μｇ／ｄＬ，收缩压显著高于对照组，多元逐步回归分析发现，在控制一些其他影响血压的因素后，铅接触工人的血铅水平与收缩压和舒张压均有剂量－反应关系。     

Comparison Between the Effects of 2-Selenium Bridged β-Cyclodextrin and Ebselen on Treating SHRsp Stroke

A glutathione peroxidase（GPX） mimic, 2-selenium bridged β-cyclodextrin（2-SeCD）, was synthesized. In order to examine its role and mechanism in treating stroke we chose stroke-prone spontaneously hypertensive rats（SHRsp） as animal model. 56 SHRsps of 8-week olds were randomly divided into several groups： test groups （low, moderate, high dose of 2-SeCD） and control groups（positive and negative）. After onset of the stroke, the rats in test groups were orally administrated with different amounts of 2-SeCD, the positive control group with ebselen, and the negative control group with drinking water. The treatment lasted two weeks, followed by observation of the rats for 10 days, meanwhile blood pressure, biochemical parameters of plasma, and the contents of nitric oxide（NO） and malondialdehyde（MDA） in plasma and brain were determined. The results show that there were significant differences in contents of NO and MDA in plasma and brain between the test groups（high, moderate dose of 2-SeCD） and negative control group. The NO contents of the test groups were obviously higher than that of the negative control group （P〈0.01）. The MDA contents of the test groups（high, moderate dose of 2-SeCD） were obviously lower than that of the negative control group（P〈0.01）. The mechanism of 2-SeCD in treating stroke was discussed, which maybe related to the increase of NO and the decrease of MDA in plasma and brain tissue, but the exact mechanism should be further studied. Moreover, the tendencies of changes in systolic blood pressure, contents of NO and MDA, and other physiological parameters for the test groups were shown to be much better than the corresponding parameters for the positive group（the group with ebselen）（P〈0.05）, indicating that the treatment effect of 2-SeCD is better than that of ebselen.     

幕上高血压脑出血手术疗效的临床分析

目的：探讨分析幕上高血压脑出血的手术时机、手术方式以及术中的注意事项。方法：通过对我科自2004年3月至2010年12月收治的208例幕上高血压脑出血病例采取不同的手术方式的治疗，然后根据患者术后1年的恢复情况的分析，探讨患者预后与手术方式、手术时机、术中注意事项的关系。结果：本组共208例患者，术后1年左右随访病人能自行下床行走者87例，需搀扶或拄拐行走者59例，不能行走者42例，死亡20例。结论：幕上高血压脑出血患者的预后除与脑出血的部位，出血的量有关外，还与手术方式、手术时机、术中注意事项密切相关。临床上可针对不同的病例采取不同的手术方式，把握好手术时机，严格注意术中操作，以改善患者的预后，提高患者的生存质量。     

食盐与心血管结局

介绍了食盐与心血管结局关系的最新研究结果,食盐摄入量与心血管结局之间呈J形关系;低盐和高盐都增加心血管危险;不支持普遍减盐推荐。     

基于特征增强的高血压视网膜病变分类方法研究

高血压视网膜病变是由高血压所引起的眼底疾病,传统分类方法主要是基于区域特征进行分析,识别依据较为单一,准确度不高。为提高分类准确度,本文提出了一种基于特征增强机制的高血压视网膜病变分类方法,设计了基于不同图像色彩空间的眼底图像特征增强方法,增强眼底照片中的病灶特征,提高模型的输入特征值,将处理后的图片输入改进的DenseNet模型中进行分类,从而提高高血压视网膜病变(HR)分类的准确度。采用公开数据集OIA-ODIR对本文提出的基于特征增强的高血压视网膜病变分类方法进行测试,其敏感性、特异性、准确率分别达到97.09%、98.79%、98.67%,与现有的HR分类方法进行分析对比,本文提出的分类方法效果更佳。