排序方式: 共有25条查询结果,搜索用时 15 毫秒
1.
Fan Yi Lin-Zhen Liu Mei-Jiang Zhang Ting-Ting Wang Jian-Nong Ye 《Analytical letters》2018,51(9):1358-1372
The primary clinical diagnosis of Alzheimer’s disease is mainly based on medical history and neuropsychiatric inventory. It is urgent to seek biological indicators with better sensitivity and higher specificity to clinically diagnose and evaluate Alzheimer’s disease. In this work, an electrophoretic method based on 2-thiobarbituric acid derivatization and amperometric detection was developed to determine formaldehyde as a urinary biomarker of Alzheimer’s disease. Under the optimum conditions, the formaldehyde derivative was well separated from the coexisting interferences in urine sample. The limit of detection for formaldehyde was 80.0?nM (2.4?ng/?mL) based on an electrophoretic stacking technology. The average recovery values were in the range of 91.7–110%, and the relative standard deviation values were less than 4.1%. This method has been applied to analyze human urine samples from healthy volunteers and patients with different degrees of Alzheimer’s disease. The assay results showed that the content of urinary formaldehyde in patients suffering Alzheimer’s disease was significantly higher than that in healthy subjects (P?0.01), suggesting that urinary formaldehyde may be speculated to be an auxiliary noninvasive biomarker for the preliminary diagnosis of Alzheimer’s disease. High separation efficiency, simple sample preparation, environmental friendliness, and low cost are the main advantages of this proposed method. 相似文献
2.
生物组织光传播的时域特征分析 总被引:3,自引:0,他引:3
采用蒙特卡罗方法对脉冲光在组织中传播的时域特征作了研究,并把计算结果与漫射理论的解析解作了比较,文中详细分析了组织光学特性参数与组织表面时间分辨的漫反射光分布之间的关系。结果表明:散射系影响着漫反射光强到达峰值的时间,吸收系数影响着漫反射光强在峰值之后随时间下降的速度,而g因子对响应曲线的前沿影响较大,在后沿阶段基本上没有影响。 相似文献
3.
Walter Schempp 《Acta Appl Math》1997,48(2):185-234
Due to its unequalled advantages, the magnetic resonance imaging (MRI) modality has truly revolutionized the diagnosis and evaluation of pathology. Because many morphological anatomic details that may not be visualized by other high tech imaging methods can now be readily shown by diagnostic MRI, it has already become the standard modality by which all other clinical imaging techniques are measured. The unique quantum physical basis of the MRI modality combined with the imaging capabilities of current computer technology has made this imaging modality a target of interdisciplinary interest for clinicians, physicists, biologists, engineers, and mathematicians. Due to the fact that MRI scanners perform corticomorphic processing, this modality is by far more complex than all the other high tech clinical imaging techniques. The purpose of this paper is to outline a phase coherent wavelet approach to Fourier transform MRI. It is based on distributional harmonic analysis on the Heisenberg nilpotent Lie group G and the associated symplectically invariant symbol calculus of pseudodifferential operators. The contour and contrast resolution of MRI scans which is controlled by symplectic filter bank processing gives the noninvasive MRI modality superiority over X-ray computed tomography (CT) in soft tissue differentiation. 相似文献
4.
5.
Non-invasive and low-artifact in vivo brain imaging by using a scanning acoustic-photoacoustic dual mode microscopy
下载免费PDF全文
![点击此处可从《中国物理 B》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Wentian Chen 《中国物理 B》2022,31(4):44304-044304
Photoacoustic imaging is a potential candidate for in vivo brain imaging, whereas, its imaging performance could be degraded by inhomogeneous multi-layered media, consisted of scalp and skull. In this work, we propose a low-artifact photoacoustic microscopy (LAPAM) scheme, which combines conventional acoustic-resolution photoacoustic microscopy with scanning acoustic microscopy to suppress the reflection artifacts induced by multi-layers. Based on similar propagation characteristics of photoacoustic signals and ultrasonic echoes, the ultrasonic echoes can be employed as the filters to suppress the reflection artifacts to obtain low-artifact photoacoustic images. Phantom experiment is used to validate the effectiveness of this method. Furthermore, LAPAM is applied for in-vivo imaging mouse brain without removing the scalp and the skull. Experimental results show that the proposed method successfully achieves the low-artifact brain image, which demonstrates the practical applicability of LAPAM. This work might improve the photoacoustic imaging quality in many biomedical applications which involve tissues with complex acoustic properties, such as brain imaging through scalp and skull. 相似文献
6.
XiaoRongZHOU PeiFangLIU LinZHUANG JunTaoLU 《中国化学快报》2004,15(7):823-826
Mass spectrometer is connected through an adaptor to a sealed small battery to probe the gas phase changes inside the battery. The factors influencing the response time are analyzed with a simplified model. The feasibility of the new technique is demonstrated with a Ni-Cd battery, showing different profiles of MS intensities for O2 and H2. Compared with gas chromatography, this technique has the advantage of being noninvasive and should be useful for the study and diagnostic examination of small sealed batteries. 相似文献
7.
Finite curved boundaries are unavoidable in the practical field of non-invasive tissue spectroscopy. This being the case, a technique derived from the microscopic Beer-Lambert law (MBL) can be applied regardless of what geometry is assumed. Here, experimental tests on a type of time integrated spectroscopy based on the MBL for a tissue-like phantom with curved boundaries are presented. The experiments employed a cylindrical liquid phantom 56 mm in diameter, which resembles a human forearm. Two independent measurements were made on the surface of the phantom at various absorption levels (the absorption coefficients of the phantom were from 2.45 × 10−3 to 4.12 × 10−2 mm−1 at 782 nm), one in the direction along the circumference and the other along the long axis of symmetry. In both cases, the absorber concentrations were successfully recovered within error values of a few percent using a single equation. 相似文献
8.
9.
Noninvasive temperature estimation by detecting echo-strain change including thermal expansion
下载免费PDF全文
![点击此处可从《中国物理》网站下载免费的PDF全文](/ch/ext_images/free.gif)
This article studies the feasibility of noninvasive temperature estimation
by detecting echo-strain including thermal expansion in therapeutic
ultrasound treatment. This technique evaluates distributions of echo-strain
and temperature inside the tissue by detecting echo signals pre- and
post-heating, in combination with the temperature dependence of sound speed
and thermal expansion. In the computer simulation and experimental study,
echo signals pre- and post-heating are acquired and then the temperature
elevation is evaluated by correlation analysis. Results demonstrate that
this technique can effectively extend the measured temperature range up to
75$^{\circ}$C with an accuracy of $\pm $2$\,^{\circ}$C. 相似文献
10.
Hequn Wang Naiyan Huang Jianhua Zhao Harvey Lui Mladen Korbelik Haishan Zeng 《Journal of Raman spectroscopy : JRS》2011,42(2):160-166
We have developed a micro‐Raman spectrometer system for use to differentiate tumor lesions from normal skin using an in vivo animal model. A study of 494 Raman spectra from 24 mice revealed different spectral patterns at different depths and between normal and tumor‐bearing skin sites. A peak at 899 cm−1 (possibly from proline or fatty acids) and one with higher intensity in the 1325–1330 cm−1 range (assigned to nucleic acids) were correlated with the presence of tumors, which can potentially be used as biomarkers for skin cancer detection. Spectral diagnosis performed on the murine tumor model achieved a diagnostic sensitivity of 95.8% and specificity of 93.8%. These results encourage us to develop further the use of confocal Raman spectroscopy as a clinical tool for noninvasive human skin biochemical analysis, particularly in relation to skin cancer. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献