排序方式: 共有113条查询结果,搜索用时 15 毫秒
1.
Data on methods for the production of isatin and indole aldoximes, ketoximes, and amidoximes and their reactions are reviewed. Individual syntheses of new heterocycles from indole and isatin oximes are discussed. The principal results from investigation of the biological activity of derivatives of the oximes are also presented. 相似文献
2.
3.
《合成通讯》2013,43(13):1747-1752
Abstract 5‐Aryl‐2,10‐bis(arylmethylene)‐2,3,6,7,8,9‐hexahydro‐5H,10H‐cyclohepteno[1,2‐d]thiazolo[3,2‐a]pyrimidin‐3‐ones undergo a regioselective 1,3‐dipolar cycloaddition reaction with the azomethine ylide derived from isatin and sarcosine to give a new class of complex spiropyrrolidines in good yield. X‐ray crystal structure analysis of one of the products confirms the structure and regiochemistry of the cycloadditions. 相似文献
4.
ABSTRACT The asymmetric cross-aldol reaction of simple ketones (acetone, cyclohexanone) with isatin derivatives in the presence of crude extract from earthworms as green and effective biocatalyst proceeds easily in MeCN/H2O (1:1) as solvent to afford 3-hydroxy-2-oxindoles derivatives. Ten compounds were synthesized in high yields (62–88%) and moderate ee (29–42%). Structure of the synthesized compounds has been characterized on the basis of NMR spectra and CHN analysis. The ee of the obtained compounds was determined by chiral phase HPLC analysis. 相似文献
5.
A synthesis of chiral optically active 3-hydroxyoxindoles with 1,3-disubstituted 2,2-dimethyl-cyclobutane structural fragment
by the Et2NH-catalyzed aldol reaction of indoline-2,3-diones with (−)-(1S,3S)-pinonic acid derivatives is described.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1540–1543, July, 2008. 相似文献
6.
Samia R. El-ezbawy Aboel-Magd A. Abdel-wahab 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3-4):285-289
Abstract 4-Amino-halonitrodiphenyl sulfides(I) and/or 4-amino-halonitrodiphenyl sulfones have been found to react with isatin, N-acetyl isatin, isatin-N-Mannich bases, indole-3-carboxaldehyde and N-substituted indole-3-carboxaldehyde producing the corresponding indole derivatives. The biological activity of some of these products was screened against selected strains of bacteria. 相似文献
7.
Prof. Dr. Yasunori Yamamoto Masaaki Yohda Tomohiko Shirai Prof. Dr. Hajime Ito Prof. Dr. Norio Miyaura 《化学:亚洲杂志》2012,7(10):2446-2449
A chiral O‐linked C2‐symmetric bidentate phosphoramidite (Me‐BIPAM) was found to be efficient for the ruthenium‐catalyzed addition of arylboronic acids to isatins. Asymmetric synthesis of 3‐aryl‐3‐hydroxy‐2‐oxindoles by 1,2‐addition of arylboronic acids to isatins was carried out in the presence of [RuCl2(PPh3)3]/(R,R)‐Me‐BIPAM and KF, resulting in an enantioselectivity as high as 90 % ee. It was found that the reaction with N‐protected isatins proceeds with high yields and good enantioselectivities. The best protective groups on the nitrogen atom were different depending on the substituents on the aromatic ring. The use of a N‐benzyl group resulted in excellent enantioselectivities in many substrates compared with other groups. 相似文献
8.
《Journal of Coordination Chemistry》2012,65(24):4263-4276
Condensation of 1H-indole-2,3-dione (isatin) with (R)-(Ar)-ethylamines gives enantiopure Schiff bases, 3-{(R)-(Ar)-ethylimino}-1,3-dihydro-indol-2-one (HL) {Ar?=?Ph (HL1), 2-MeOC6H4 (HL2), 4-MeOC6H4 (HL3), 4-BrC6H4 (HL4), and 1-naphthyl (HL5)}. The Schiff bases readily coordinate to [Rh(μ-O2CMe)(η4-cod)]2 (cod?=?1,5-cyclooctadiene) to give mononuclear [Rh(η4-cod){3-((R)-(Ar)-ethylimino)-3H-indol-2-olato}] {Ar?=?Ph (1), 4-MeOC6H4 (2), and 4-BrC6H4 (3)}, respectively. The Schiff bases and complexes have been fully characterized by IR, UV-Vis, 1H-NMR, mass, and circular dichroism (CD) spectrometry. Polarimetry and CD measurements show the enantiopurity of the Schiff bases as well as the complexes. 1H NMR measurements reveal slow conversion of the lactam to the enol form of the Schiff bases in solution. In the solid state the lactam form dominates as shown by crystal structures of HL1 and HL4. While gross structural features of both are similar, the molecules differ significantly in the relative orientations of the aryl and lactam rings. The difference is mostly rotation about the N2–C9 bond with different C8–N2–C9–C11 torsion angle of +89.77(12)° for HL1 and C2–N2–C9–C11 of +106.8(3)° for HL4. 相似文献
9.
10.
1-Benzopyran-4(4H)-one derivatives have been successfully employed as novel activated alkenes in the Baylis-Hillman coupling with heteroaromatic-aldehydes, nitrobenzaldehydes and isatin-derivatives and the corresponding adducts, derived from pyridine-2-carboxaldehyde, have been transformed into a novel indolizine-fused-chromone framework. 相似文献