X-ray microanalysis of uterine epithelial cells in culture

The ionic composition of the uterine fluid, secreted by the endometrium, is of importance for fertilization and embryonic development. Little, however, is known about the ion transport mechanisms in the uterine epithelial cells. Because it is difficult to study ion transport in this tissue in situ, a method was developed to culture mouse uterine epithelial cells for X-ray microanalysis in the electron microscope, in order to allow the study of ion transport. Our data suggest the presence of a number of ion transport mechanisms in the cultured uterine epithelial cells. The cells appear to possess a ouabain-sensitive Na⁺---K⁺-ATPase, an amiloride-sensitive Na⁺---H⁺ antiporter, cAMP- and Ca²⁺-activated chloride channels, and volume-activated chloride efflux and influx mechanisms. In addition, chloride efflux can be stimulated by cholinergic and alpha-adrenergic agonists. Only a few of these mechanisms had been studied previously in the uterine epithelium.     

TVS和CEUS诊断子宫内膜良恶性病变的价值

本次研究的目的是探讨子宫内膜良恶性病变中,经阴道超声检查(TVS)和超声造影(CEUS)的鉴别诊断价值。选取确诊的子宫内膜病变患者108例,给予TVS和CEUS检查。经病理学检查,恶性病变60例,良性病变48例;CEUS诊断子宫内膜良恶性病变的灵敏性、准确性和阴性预测值明显高于TVS检查(P<0.05);恶性病变和良性病变阻力指数(RI)、达峰时间(TTP)与峰值强度(Peak)有明显差异(P<0.05);Ⅲ~Ⅳ和Ⅰ~Ⅱ期RI、TTP和Peak有明显差异(P<0.05);RI、Peak和TTP诊断子宫内膜恶性病变的ROC曲线下面积分别为0.740、0.789和0.856,P<0.05。相比较TVS,CEUS鉴别诊断子宫内膜良恶性疾病有较好的价值,值得临床应用。     

超声多模态评分评价RSA患者子宫容受性的价值

本文探讨复发性自然流产(RSA)患者子宫内膜超声多模态评分的变化及其意义。选取确诊的RSA患者134例作为RSA组、选取具有生育史但无自然流产史的年龄相近妇女130例作为对照组;对比两组的一般资料、生殖激素水平、子宫内膜超声多模态评分、并分析子宫内膜超声多模态评分与RSA的关系。经检验,RSA组子宫动脉的搏动指数(PI)、阻力指数(RI)及收缩末期峰值/舒张末期峰值(S/D)均高于对照组,差异均具有统计学意义(P<0.05);RSA组子宫内膜超声多模态评分低于对照组,差异均具有统计学意义(P<0.05);绘制ROC曲线结果显示:子宫内膜超声多模态评分预测发生RSA的ROC曲线下面积(AUC)为0.849、灵敏度为89.31%、特异度为76.44%。子宫内膜超声多模态评分对于RSA患者子宫内膜容受性具有较高的评估作用,同时可以作为临床上预测RSA发生的监测指标。