Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle

Recent experiments have pointed out that cellular uptake is strongly dependent on the physical dimensions of endocytosed nanoparticles and tile optimal radius of endocytosed virus-like particle coated by transferrin is around 50 nm. As the same time, the dimensions of receptor-ligand complex have strong effects on the size-dependent exclusion of proteins ill cell environments. Inspired by these experimental results, a continuum elastic model is constructed to resolve the relationship between the dinlensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle. These results demonstrate that the optimal radius of endocytosed virus-like particle depends on the dimensions of reeeptor-ligand complex and the dimension of receptor-ligand complex reduces the depletion zone.