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排序方式: 共有134条查询结果,搜索用时 15 毫秒
1.
Jonathan M. Levin Lawrence L. Wald Marc J. Kaufman Marjorie H. Ross Luis C. Maas Perry F. Renshaw 《Journal of magnetic resonance (San Diego, Calif. : 1997)》1998,130(2):292-295
Residual effects of an initial bolus of gadolinium contrast agent have been previously demonstrated in sequential dynamic susceptibility contrast MR experiments. While these residual effects quickly reach a saturation steady state, their etiology is uncertain, and they can lead to spurious estimates of hemodynamic parameters in activation experiments. The possible influence ofT1effects is now investigated with experiments in whichT1weighting is varied as well as with serial regionalT1measurements. Little evidence for significant residualT1effects is found, suggesting instead that susceptibility effects underlie these observations. An initial saturation dose of contrast agent minimizes this effect. 相似文献
2.
Jun-Jie Shi Qi-Hui Jiang Tian-Ning Zhang Hao Sun Wen-Wen Shi Hendra Gunosewoyo Fan Yang Jie Tang Tao Pang Li-Fang Yu 《Molecules (Basel, Switzerland)》2021,26(5)
Sigma-1 (σ-1) receptor agonists are considered as potential treatment for stroke. TS-157 is an alkoxyisoxazole-based σ-1 receptor agonist previously discovered in our group. The present study describes TS-157 profile in a battery of tests for cerebral ischemia. Initial evaluation demonstrated the compound’s safety profile and blood–brain barrier permeability, as well as its ability to induce neurite outgrowth in vitro. The neurite outgrowth was shown to be mediated via σ-1 receptor agonism and involves upregulation of ERK phosphorylation (pERK). In particular, TS-157 also significantly accelerated the recovery of motor function in rats with transient middle cerebral artery occlusion (tMCAO). Overall, the results herein support the notion that σ-1 receptor agonists are potential therapeutics for stroke and further animal efficacy studies are warranted. 相似文献
3.
Yasushi MIYASHITA 《Proceedings of the Japan Academy. Series B, Physical and biological sciences》2022,98(3):93
The cerebral cortex performs its computations with many six-layered fundamental units, collectively spreading along the cortical sheet. What is the local network structure and the operating dynamics of such a fundamental unit? Previous investigations of primary sensory areas revealed a classic “canonical” circuit model, leading to an expectation of similar circuit organization and dynamics throughout the cortex. This review clarifies the different circuit dynamics at play in the higher association cortex of primates that implements computation for high-level cognition such as memory and attention. Instead of feedforward processing of response selectivity through Layers 4 to 2/3 that the classic canonical circuit stipulates, memory recall in primates occurs in Layer 5/6 with local backward projection to Layer 2/3, after which the retrieved information is sent back from Layer 6 to lower-level cortical areas for further retrieval of nested associations of target attributes. In this review, a novel “dynamic multimode module (D3M)” in the primate association cortex is proposed, as a new “canonical” circuit model performing this operation. 相似文献
4.
本文选取74例急性脑梗死(ACI)患者作为研究对象,入院时根据美国国立卫生院卒中量表(NIHSS)评分分为重度组(NIHSS评分>15分,n=21)、中度组(NIHSS评分5?15分,n=24)、轻度组(NIHSS评分<5分,n=29),均接受血清copeptin和IL-18水平检测及螺旋CT成像检查.结果发现,随AC... 相似文献
5.
针对不确定非线性生物系统—W illis环状脑动脉瘤系统,利用高斯型模糊逻辑系统的逼近能力及新构造的Lyapunov函数,基于模糊建模提出了一种自适应模糊控制器设计的新方案.该方案把逼近误差引入到控制器设计条件中用以改善系统的动态性能.不但设计简单还保证了控制方法的鲁棒性与稳定性.通过反向传播算法调整模糊基函数参数及递归最小二乘法调整参数向量,θ更新控制律,实现了理想跟踪.从理论上研究了脑动脉瘤内血流速度的非线性行为及控制,具有实际意义.仿真结果表明该控制方法的有效性. 相似文献
6.
近红外光谱监测体外循环手术中脑组织氧合状况的研究 总被引:3,自引:3,他引:3
体外循环手术中,为防止因脑氧供需失衡导致脑缺氧,就要实时监测患者局部脑组织的氧合状况,以根据其变化调整生理参数或采取应急手段。用该研究小组自行研制的近红外仪器(使用一个双波长的近红外光源和两个近红外检测器)监测心脏手术中患者的脑氧,可以求出局部脑组织血红蛋白浓度的变化,并根据稳态空间分辨光谱(SRS)算法求出局部脑组织的氧饱和度(rSO2)。体外循环中用监护仪监测患者的混合静脉血氧饱和度(SvO2)等生理参数。测得的血红蛋白浓度变化容易受到干扰,而rSO2的抗干扰性能较好。rSO2在整个手术过程中都可以监测到,而SvO2只能在体外循环过程中监测到。多数患者rSO2和SvO2存在正向相关性,但二者的相关系数并不很高。这是因为SvO2是大静脉的血氧饱和度,而测得的rSO2反映局部脑组织的氧合状况,二者的生理意义不同。实验结果表明,体外循环手术中rSO2可以反映患者脑组织氧合状况的变化,而仅仅监测SvO2是不够的。 相似文献
7.
A modified Stroop color-word task has been developed to activate the prefrontal cortex as a cognitive task and it has been tried to clarify whether change in the cerebral hemodynamics after ingesting caffeine is associated with change in performance on the modified Stroop task in young male subjects. In this modified task, subjects were instructed to quickly select a colored disk on a computer screen in response to an instruction, i.e. “color” or “meaning”, presented simultaneously with one color word at each trial. The color of the presented color word was discordant with the meaning of the word. Relative changes in blood volume and oxygenation in the prefrontal association cortex were measured noninvasively using continuous-wave near-infrared spectroscopy. The results showed that caffeine ingestion decreased blood volume and oxygenated hemoglobin concentration in the brain during the modified Stroop task, and that the individual change in the latter was related to change in performance on the task following caffeine ingestion. 相似文献
8.
9.
随着计算机成像技术的发展,计算机断层扫描(CT)和核磁共振(MRI)已经广泛应用于临床,特别是血管类疾病的诊断,比如动脉狭窄、血管瘤、血管畸形等。除了可以提供高分辨率的静态图像,先进的MRI技术还可以通过时间序列直接反映血流动力学的变化。而基于计算机成像和三维重建技术,血流动力学的参数又可以通过计算流体力学的方法进行详细的分析。如何将血流动力学参数和临床诊断相结合是近年来在转化医学领域研究的热点。文中将结合文献调研和作者自己的研究工作对基于医学图像的血流动力学分析进行综述,并探讨未来的研究方向。 相似文献
10.
赵益炼 《广东微量元素科学》2006,13(10):69-70
总结了15例急性脑梗死患者动脉介入治疗术后的护理体会,阐述了术后在心理护理、呼吸道护理、持续抗凝治疗、防止脑出血以及出院指导、康复锻炼等方面所采取的措施,这些是预防重要并发症发生,使患者顺利康复的重要因素。 相似文献