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Despite intense research on the blood oxygenation level-dependent (BOLD) signal underlying functional magnetic resonance imaging, our understanding of its physiological basis is far from complete. In this study, it was investigated whether the so-called poststimulus BOLD signal undershoot is solely a passive vascular effect or actively induced by neural responses. Prolonged static and flickering black-white checkerboard stimulation with isoluminant grey screen as baseline condition were employed on eight human subjects. Within the same region of interest, the positive BOLD time courses for static and flickering stimuli were identical over the entire stimulus duration. In contrast, the static stimuli exhibited no poststimulus BOLD signal undershoot, whereas the flickering stimuli caused a strong BOLD poststimulus undershoot. To ease the interpretation, we performed an additional study measuring both BOLD signal and cerebral blood flow (CBF) using arterial spin labeling. Also for CBF, a difference in the poststimulus period was found for the two stimuli. Thus, a passive blood volume effect as the only contributor to the poststimulus undershoot comes short in explaining the BOLD poststimulus undershoot phenomenon for this particular experiment. Rather, an additional active neuronal activation or deactivation can strongly modulate the BOLD poststimulus behavior. In summary, the poststimulus time course of BOLD signal could potentially be used to differentiate neuronal activity patterns that are otherwise indistinguishable using the positive evoked response.  相似文献   
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本文以等效电路模型为基础模型,结合动态气体压力模型和动态热传输模型建立了集总参数模型,在SIMULINK环境下,利用建立的模型模拟了电池启动过程,发现了电压的下冲现象,且电压的响应时间与电池温度的响应时间基本一致,说明启停过程中电池温度对电池的动态性能影响很大. 进一步从温度角度对模型中决定电池输出电压大小的热力学电动势、活化过电势、欧姆过电势和浓差过电势的动态响应情况进行了分析,发现启动过程电压的下冲现象主要由电池活化过电势和欧姆过电势的过冲引起;当以阶跃信号形式输入温度时,启动过程电池输出电压响应很快且未发生下冲现象,说明提高电池温度的响应速度能够改善电池的动态性能.  相似文献   
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异质预期条件下房价波动非线性延滞差分方程   总被引:4,自引:0,他引:4  
通过建立蛛网模型分析经济变动对具有后向预期性质的房地产市场的价格波动的影响.其中,市场需求函数采用简单使用者成本模型,而供给函数则以存量-流量模型为基础.通过建立一组n阶延滞差分方程来分析一类异质后向预期房价波动模型的性质,例如均衡或振荡,收敛或偏离等.结果显示需求弹性小于供给弹性并不是形成振荡的必要条件.房价的波动会随着异质后向预期假设以及其他内生因素的不同而产生本质不同的变化.  相似文献   
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China's first interest rate hike during the last decade, aiming to cool down the seemingly overheated real estate market, had aroused more caution on housing market. This paper aims to analyze the housing price dynamics after an unanticipated economic shock, which was believed to have similar properties with the back ward- looking expectation models. The analysis of the housing price dynamics is based on the cobweb model with a simple user cost affected demand and a stock-flow supply assumption. Several nth-order delay rational difference equations are set up to illustrate the properties of housing dynamics phenomena, such as the equilibrium or oscillations, overshoot or undershoot and convergent or divergent, for a kind of heterogeneous backward-looking expectation models. The results show that demand elasticity is less than supply elasticity is not a necessary condition for the occurrence of oscillation. The housing price dynamics will vary substantially with the heterogeneous backward-looking expectation assumption and some other endogenous factors.  相似文献   
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