全文获取类型
收费全文 | 1500篇 |
免费 | 136篇 |
国内免费 | 123篇 |
专业分类
化学 | 646篇 |
晶体学 | 7篇 |
力学 | 347篇 |
综合类 | 12篇 |
数学 | 356篇 |
物理学 | 391篇 |
出版年
2024年 | 3篇 |
2023年 | 7篇 |
2022年 | 31篇 |
2021年 | 40篇 |
2020年 | 35篇 |
2019年 | 23篇 |
2018年 | 35篇 |
2017年 | 33篇 |
2016年 | 46篇 |
2015年 | 44篇 |
2014年 | 66篇 |
2013年 | 84篇 |
2012年 | 69篇 |
2011年 | 87篇 |
2010年 | 84篇 |
2009年 | 108篇 |
2008年 | 118篇 |
2007年 | 90篇 |
2006年 | 109篇 |
2005年 | 63篇 |
2004年 | 70篇 |
2003年 | 58篇 |
2002年 | 51篇 |
2001年 | 28篇 |
2000年 | 51篇 |
1999年 | 38篇 |
1998年 | 40篇 |
1997年 | 31篇 |
1996年 | 31篇 |
1995年 | 32篇 |
1994年 | 45篇 |
1993年 | 39篇 |
1992年 | 11篇 |
1991年 | 8篇 |
1990年 | 5篇 |
1989年 | 9篇 |
1988年 | 10篇 |
1987年 | 11篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1981年 | 3篇 |
1978年 | 2篇 |
1959年 | 1篇 |
排序方式: 共有1759条查询结果,搜索用时 15 毫秒
1.
Enantiomeric Cyclic Peptides with Different Caco‐2 Permeability Suggest Carrier‐Mediated Transport
下载免费PDF全文
![点击此处可从《Chemistry (Weinheim an der Bergstrasse, Germany)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
B. Sc. Eduard Puig Prof. Dr. Beat Ernst Prof. Dr. Horst Kessler 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(22):8023-8027
Recently, oral absorption of cyclic hexapeptides was improved by N‐methylation of their backbone amides. However, the number and position of N‐methylations or of solvent exposed NHs did not correlate to intestinal permeability, measured in a Caco‐2 model. In this study, we investigate enantiomeric pairs of three polar and two lipophilic peptides to demonstrate the participation of carrier‐mediated transporters. As expected, all the enantiomeric peptides exhibited identical lipophilicity (logD7.4) and passive transcellular permeability determined by the parallel artificial membrane permeability assay (PAMPA). However, the enantiomeric polar peptides exhibited different Caco‐2 permeability (Papp) in both directions a–b and b–a. The same trend was observed for one of the lipophilic peptide, whereas the second lipophilic enantiomer pair showed identical Caco‐2 permeability (within the errors). These findings provide the first evidence for the involvement of carrier‐mediated transport for peptides, especially for those of polar nature. 相似文献
2.
A. Shaporenko A. Terfort M. Grunze M. Zharnikov 《Journal of Electron Spectroscopy and Related Phenomena》2006
Analysis of photoemission spectra of complex thioaromatic self-assembled monolayers (SAMs) requires the knowledge and understanding of such spectra for the basic systems. Keeping this goal in mind, synchrotron-based high-resolution X-ray photoelectron spectroscopy was used to characterize SAMs formed from the simplest thioaromatic compounds, namely thiophenol, 1,1′-biphenyl-4-thiol and 1,1′;4′,1″-terphenyl-4-thiol on evaporated Au(1 1 1) and Ag(1 1 1) substrates. The acquired S 2p and C 1s spectra were analyzed in terms of fine structure and initial and final state effects in the photoemission process. The assignment of the individual spectral features was considered in detail. Conclusions on quality and chemical and structural homogeneity of the investigated SAMs were derived. 相似文献
3.
采用交替沉积磁控溅射工艺制备了超薄多层的FeCoB SiO2 磁性纳米颗粒膜 .利用x射线衍射仪、扫描探针显微镜、透射电子显微镜分析了薄膜的微结构和形貌特征 .采用振动样品磁强计、四探针法、微波矢量分析仪及谐振腔法测量薄膜试样的磁电性能和微波复磁导率 .重点对SiO2 介质相含量、薄膜微结构对电磁性能产生重要影响的机理做了分析和探讨 .结果表明 :这类FeCoB SiO2 磁性纳米颗粒膜具有良好的软磁性能和高频电磁性能 ,2GHz时的磁导率 μ′高于 70 ,可以应用于高频微磁器件或微波吸收材料的设计 相似文献
4.
The steady-state two-phase flow non-linear equation is considered in the case when one of phases has low effective permeability in some periodic set, while on the complementary set it is high; the second phase has no contrast of permeabilities in different zones. A homogenization procedure gives the homogenized model with macroscopic effective permeability of the second phase depending on the gradient and on the second order derivatives of the macroscopic pressure of the first phase. This effect cannot be obtained by classical (one small parameter) homogenization. To cite this article: G.P. Panasenko, G. Virnovsky, C. R. Mecanique 331 (2003). 相似文献
5.
Ch. Tsitouras 《Numerical Algorithms》2007,44(3):291-307
Runge–Kutta (RK) pairs furnish approximations of the solution of an initial value problem at discrete points in the interval
of integration. Many techniques for enriching these methods with continuous approximations have been proposed. Here we construct
C
1 continuous, eighth and ninth order interpolation methods for a recently appeared RK pair of orders 9(8). These interpolants
share a very small leading truncation error making them suitable for use at quadruple precision, i.e. 32–33 decimal digits
of accuracy. Extended numerical results justify our effort. 相似文献
6.
An initial boundary value problem for the dynamic system of anisotropic elasticity in a half space is studied in the paper. A novel method of finding an exact solution of this problem for a special polynomial form of initial data and inhomogeneous term of the system is described. On the base of this method the simulation of elastic waves in different homogeneous anisotropic half spaces is implemented. 相似文献
7.
铸膜液的溶剂体系(溶剂和非溶剂)对不对称膜形态的形成有重要作用。为了探索溶剂和透气性间的关系,本文考虑到了制备BCA梯度密度不对称膜的各种溶剂的一系列物理参数,得到了一些定性结果,并指出了更全面、明确、解释两者关系的研究方向。 相似文献
8.
郑州工程学院数理系 《数学物理学报(A辑)》2004,24(3):329-336
该文考虑一类新的非线性方程(|ut|r-2ut)t-Δutt-Δu-ρ(t)Δut=f(u) 的初边值问题,利用小扰动法证明了整体弱解的
存在性,借用位势井的概念得到了解的稳定性.〖HT5”H〗关键词:〖HT5”SS〗非线性发展方程;初边值问题;整体弱解;稳定性. 相似文献
9.
10.
Rinaldo M. Colombo Alessandro Groli 《Journal of Mathematical Analysis and Applications》2004,291(1):82-99
In the present note, the theory of shift differentiability for the Cauchy problem is extended to the case of an initial boundary value problem for a conservation law. This result allows to exhibit an Euler-Lagrange equation to be satisfied by the extrema of integral functionals defined on the solutions of initial boundary value problems of this kind. 相似文献