微量元素在风湿关节病领域的研究

通过综述多年来的临床观察与实验研究，发现风湿关节病存在着某些酶活性的缺陷，同时伴有相应常量元素或微量元素代谢障碍，两者密切相关，在风湿关节炎的综合治疗中，适当调整相应元素的浓度可提高疗效和改善体质．文中还介绍如何调整微量元素治疗的体会。     

SERS标记纳米粒子用于免疫识别

激光拉曼光谱技术近年来已成为研究生物分子结构常用的光谱手段.尤其在研究水溶液中蛋白质的结构和构象方面发挥了重要作用.然而,常规拉曼光谱的信号强度很低,限制了其在各个领域中的应用.表面增强拉曼光谱(SERS)和表面增强共振拉曼光谱(SERRS)技术可使信号增强6～10个数量级,尤其是SERS技术已发展到检测单分子的水平,更为其在生物方面的应用开拓了新的局.     

Global analysis of multiple routes of disease transmission on heterogeneous networks

In this paper, we propose and study an SIS epidemic model with multiple transmission routes on heterogeneous networks. We focus on the dynamical evolution of the prevalence. Through mathematical analysis, we obtain the basic reproduction number _R0$R_0$ by investigating the local stability of the disease-free equilibrium and also investigate the effects of various immunization schemes on disease spread. We further obtain that the disease will die out independent of the initial infections if the basic reproduction number is less than one, otherwise if the basic reproduction number is larger than one, the system converges to a unique endemic equilibrium, which is globally stable and thus the disease persists in the population. Our theoretical results are conformed by a series of numerical simulations and suggest a promising way for the control of infectious diseases with multiple routes.     

Epidemic threshold and immunization on generalized networks

The susceptible–infected–susceptible (SIS) model is widely adopted in the studies of epidemic dynamics. When it is applied on contact networks, these networks mostly consist of nodes connected by undirected and unweighted edges following certain statistical properties, whereas in this article we consider the threshold and immunization problem for the SIS model on generalized networks that may contain different kinds of nodes and edges which are very possible in the real situation. We proved that an epidemic will become extinct if and only if the spectral radius of the corresponding parameterized adjacent matrix (PAM) is smaller than 1. Based on this result, we can evaluate the efficiency of immune strategies and take several prevailing ones as examples. In addition, we also develop methods that can precisely find the optimal immune strategies for networks with the given PAM.     

太阳神健康饮品对学龄前儿童智商及某些生化指标的影响

选择64名5～6岁儿童。随机分为两组，分别服用太阳神健康饮品(A组)和一般乳酸奶(B组)，每天服用100ml，连服9周，检测指数包括智商(FIQ)，血红蛋白(Hb)。红细施压积(Hct)以及免疫(SIga)。经检测，服用“太阳神”健康饮品的一组(A组），其各项指数均呈显著变化，而服一般乳酸奶一组(B组)。除Hct数值显著变化外，其它则没有统计学意义。     

Effect of sonication on B cell development and immunomodulatory functions of Bursa of Fabricius

A study was initiated with the objective of evaluating the effects of sonication treatment on important quality parameters of extract of Bursa of Fabricius. Sonication of extract was done (frequency 20 kHz and various amplitude levels) at 0 °C for 10 min, 30 min, 50 min, respectively. As results, the yield of bursa peptides significantly increased (p < 0.05). Then we found sonicated bursa extract promoted the content of bursin and the CFU pre-B formation, exerted immunomodulatory function on antigen-specific immune responses in C57/BL6 mice immunized with inactivated Japanese encephalitis b virus (JEV) vaccine, including enhancing JEV-specific antibody and cytokine production, T-cell immunophenotyping and lymphocyte proliferation. Findings of the present study suggested the sonication treatment of Bursa of Fabricius could improve the yield as well as the quality of bursa peptides, indicating that sonication is effective in processing of bursa extract and could be a potential process for future immuno-pharmacological use.     

The analysis of an epidemic model on networks

The paper consider an epidemic model with birth and death on networks. We derive the epidemic threshold R₀ dependent on birth rate b, death rate d (natural death) and μ from the infectious disease and natural death, and cure rate γ. And the stability of the equilibriums (the disease-free equilibrium and endemic equilibrium) are analysed. Finally, the effects of various immunization schemes are studied and compared. We show that both targeted, and acquaintance immunization strategies compare favorably to a proportional scheme in terms of effectiveness. For active immunization, the threshold is easier to apply practically. To illustrate our theoretical analysis, some numerical simulations are also included.     

A note on immunization under a general stochastic equilibrium model of the term structure

The paper investigates the actuarial immunization problem under recent stochastic equilibrium models for the term structure of interest rates developed in the theory of finance, thereby generalizing results of Boyle (1978, 1980).     

不确定免疫理论在债券投资分析中的应用

本文基于利率风险,对半确定的免疫理论进行详细讨论,建立了在债券投资分析中应用的资产负债管理的数学模型,进而在考虑负债结构的情况下,把随机免疫方法应用于投资分析,以使利率变动所带来的风险达到最小,并指出免疫理论可应用的条件     

Macaulay durations for nonparallel shifts

Macaulay duration is a well-known and widely used interest rate risk measure. It is commonly believed that it only works for parallel shifts of interest rates. We show in this paper that this limitation is largely due to the traditional parametric modelling and the derivative approach, the Macaulay duration works for non-parallel shifts as well when the non-parametric modelling and the equivalent zero coupon bond approach are used. We show that the Macaulay duration provides the best one-number sensitivity information for non-parallel interest rate changes and that a Macaulay duration matched portfolio is least vulnerable to the downside risk caused by non-parallel rate changes under some verifiable conditions. AMS Classification 65K10 · 90C90