Radiobiological response of human hepatoma and normal liver cells exposed to carbon ions generated by Heavy Ion Research Facility in Lanzhou

Human hepatoma and normal liver cells were irradiated with ¹²C⁶⁺ ion beams (LET = 96.05 keV/μm) and γ-rays at Heavy Ion Research Facility in Lanzhou (HIRFL). The chromatid breaks and break types were detected using the premature chromosome condensation technique. Our experimental results showed that chromatid breaks seem to have a good relation with ¹²C⁶⁺ absorbed dose and ¹²C⁶⁺ are more effective to induce chromatid breaks as compared to the γ-rays. For ¹²C⁶⁺ ion irradiation the major break was isochromatid break, while chromatid breaks were dominant for γ-ray irradiation. We also observed that the Relative Biology Effectiveness (RBE) of ¹²C⁶⁺ ion is about 2.5 times higher than that of γ-rays.     

12C6＋离子辐照人胃癌细胞系BGC823的氧效应研究

氧效应; 碳离子; 人胃癌细胞系BGC823 ;兰州重离子加速器     

Neutron production at the heavy ion research facility in Lanzhou

In this work,the neutron radiation field at Heavy Ion Research Facility in Lanzhou (HIRFL) was investigated.Total neutron yields,spectra and angular distributions in the bombardment of various thick targets by 12C and 18O ions with energies up to 75 MeV/u were obtained using the activation method.The neutron dose equivalent rates of 60 MeV/u 18O on various thick targets at different angles were measured with a modified A-B remmeter.Our results are compared with those of other reports.     

Neutron dose measurement in carbon ion radiation therapy at HIRFL (IMP)

For radiation protection purposes, the neutron dose in carbon ion radiation therapy at the HIRFL (Heavy Ion Research Facility in Lanzhou) was investigated. The neutron dose from primary 12C ions with a specific energy of 100 MeV/u delivered from SSC was roughly measured with a standard Anderson-Broun rem-meter using a polyethylene target at various distances. The result shows that a maximum neutron dose contribution of 19 mSv in a typically surface tumor treatment was obtained, which is less than 1% of the planed heavy ion dose and is in reasonable agreement with other reports. Also the γ-ray dose was measured in this experiment using a thermo luminescent detector.     

超长周期慢引出主环磁铁电源控制系统设计

介绍了兰州重离子加速器冷却储存环（HIRFL-CSR）超长周期慢引出主环（CSRm）磁铁电源控制系统的设计。该系统采用基于高速以太网的分布式控制系统,选用了ARM+DSP结构的前端智能控制器,对整个运行周期的控制采用了分段处理的机制,解决了波形数据量过大而无法在前端控制器进行全波形存储的问题。该系统已经在加速器冷却储存环中通过了调试,满足了物理实验的要求。     

Neutron dose measurement in carbon ion radiation therapy at HIRFL （IMP）

For radiation protection purposes, the neutron dose in carbon ion radiation therapy at the HIRFL （Heavy Ion Research Facility in Lanzhou） was investigated. The neutron dose from primary ^12C ions with a specific energy of 100 MeV/u delivered from SSC was roughly measured with a standard Anderson-Broun rem-meter using a polyethylene target at various distances. The result shows that a maximum neutron dose contribution of 19 mSv in a typically surface tumor treatment was obtained, which is less than 1% of the planed heavy ion dose and is in reasonable agreement with other reports. Also the T-ray dose was measured in this experiment using a thermo luminescent detector.     

高灵敏度等时性回旋加速器束流相位测量系统

介绍了兰州重离子加速器（HIRFL）束流相位测量装置。该装置的研制基于双平衡混频原理，利用了高频信号混频滤波技术，具有较高的测量灵敏度。通过安装在加速器中的容性感应探针探测等时性回旋加速器束流相位历程，对于调束中获取等时场信息并对磁场进行优化,从而提高引出束流强度和束流品质是非常重要的。该装置通过等时场相位优化实验，检验了相位测量数据的可靠性，测量精度达到±0.5°。     

Status and Prospects of HIRFL Experiments

The research activities at HIRFL cover the fields of radio-biology,material science,atomic physics,and nuclear physics.This report mainly concentrates on the experiments of nuclear physics with the existing and planned experimental setups such as SHANS,RIBLL1,ETF,CSRe and PISA at HIRFL.     

HIRFL-CSR外靶实验T0探测器前端电子学原型模块设计

介绍了兰州重离子加速器冷却储存环（HIRFL-CSR）外靶实验中时间起点探测器（T0）的前端电子学原型模块的设计与测试。探索了基于过阈时间法和专用集成电路NINO芯片进行多气隙电阻板室探测器信号读出的模拟前端电路的设计技术,并实际完成了原型电子学模块的设计。此模块共集成6个测量通道,可以进行前沿甄别及电荷时间变换。目前已经在实验室条件下完成了各项电子学性能测试,包括不同甄别阈值下的时间精度测试以及不同输入信号幅度下的输出脉宽测试。测试结果表明,在100 fC至2 pC的动态范围内,此模块时间精度好于20 ps,满足应用需求,这也为进一步的电子学系统设计做好了准备。A prototype front end electronics (FEE) module is designed for the T0 detector in the External Experiment in CSR (Cooling Storage Ring) of HIRFL (Heavy Ion Research Facility in Lanzhou). Based on the Time-Over-Threshold method and NINO ASIC, a total of 6 channels are integrated in the module, and both high precision leading edge discrimination and Charge-to-Time Conversion can be achieved, which satisfies the readout requirement of MRPC (Multi-gap Resistive Plate Chamber). A series of tests were also conducted in the laboratory, including time precision tests with different thresholds and output pulse width tests with different input signal amplitudes. Test results indicate that this prototype module functions well, and the time precision is better than 20 ps in the dynamic range from 100 fC to 2 pC, which is beyond application requirement. Through this work, preparation is made for the future readout system design.     

Neutron production at the heavy ion research facility in Lanzhou

In this work, the neutron radiation field at Heavy Ion Research Facility in Lanzhou (HIRFL) was investigated. Total neutron yields, spectra and angular