Glykosylazide als Ausgangsbasis zur Gewinnung von Nucleosidanalogen, 3. Mitt. Synthese von Alkylaminotetrazol- und Uretidinonnucleosiden

The -ribofuranosylazide1 is transformed after usual derivatization by suitable protecting groups into the P–N-ylid2, which gives the corresponding N-Glykosyl-N-alkylcarbodiimides4 and a small amount of the glykosylisocyanatde-rivative3 by reaction with alkylisocyanates. The carbodiimides4 were reacted with hydrazoic acid to give the alkylaminotetrazolnucleosides5 and finally the free nucleosidanalogs6. In the case of5 c the 5-aziridinyltetrazolnucleosid5 h was formed by an usual neighbouring group reaction. In addition the compound1 is transformed into the 3,5-diprotected anchor derivative7 by reaction withTIPSCl₂. The latter could be transformed by usual steps into the alkylaminotetra-zolnucleosides8 with a free 2-OH group. In the next step the 2-p-tolylthiocarbo-nates9 were prepared followed by transformation to the 2-desoxynucleosides10 by means of tributyltinhydride. Finally the free 2-desoxynucleosides11 were prepared. By reacting the carbodiimides4 with phenylisocyanate a mixture of the two possible regiouretidinonnucleosidderivatives12 and13 are formed. In the case of the N-glykosyl-N-allylcarbodiimide4 d only the one isomer13 d arises.

Herrn Prof. Dr.A. Neckel mit den besten Wünschen zum 60. Geburtstag gewidmet.     

Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes

Oxidative stress (OS) is a metabolic dysfunction mediated by the imbalance between the biochemical processes leading to elevated production of reactive oxygen species (ROS) and the antioxidant defense system of the body. It has a ubiquitous role in the development of numerous noncommunicable maladies including cardiovascular diseases, cancers, neurodegenerative diseases, aging and respiratory diseases. Diseases associated with metabolic dysfunction may be influenced by changes in the redox balance. Lately, there has been increasing awareness and evidence that diabetes mellitus (DM), particularly type 2 diabetes, is significantly modulated by oxidative stress. DM is a state of impaired metabolism characterized by hyperglycemia, resulting from defects in insulin secretion or action, or both. ROS such as hydrogen peroxide and the superoxide anion introduce chemical changes virtually in all cellular components, causing deleterious effects on the islets of β-cells, in turn affecting insulin production. Under hyperglycemic conditions, various signaling pathways such as nuclear factor-κβ (NF-κβ) and protein kinase C (PKC) are also activated by ROS. All of these can be linked to a hindrance in insulin signaling pathways, leading to insulin resistance. Hyperglycemia-induced oxidative stress plays a substantial role in complications including diabetic nephropathy. DM patients are more prone to microvascular as well as atherosclerotic macrovascular diseases. This systemic disease affects most countries around the world, owing to population explosion, aging, urbanization, obesity, lifestyle, etc. However, some modulators, with their free radical scavenging properties, can play a prospective role in overcoming the debilitating effects of OS. This review is a modest approach to summarizing the basics and interlinkages of oxidative stress, its modulators and diabetes mellitus. It may add to the understanding of and insight into the pathophysiology of diabetes and the crucial role of antioxidants to weaken the complications and morbidity resulting from this chronic disease.     

反铁磁链中Dzyaloshinskii–Moriya机制驱动矢量自旋手征束缚态的研究

Dzyaloshinskii-Moriya(DM)相互作用驱动的矢量自旋手征态,能和声子发生耦合,具备非常丰富的物理现象.本论文以一维反铁磁链中自旋手征-声子耦合模型为基础,研究不同声子环境下,耦合强度对自旋手征动力学演化过程的影响规律.结果表明,对自旋S=1/2的系统,在不同的声子浴(sub-Ohmic(0 1))中,均会在非相干到相干自旋涨落过程中产生无能隙一级相变,其来源是自旋手征束缚态的形成.相变发生的临界自旋-声子耦合强度正比于自旋涨落大小,反比于系统德拜频率.当自旋-声子耦合强度超过其临界值时,自旋手征束缚态的产生将极大地抑制非相干自旋涨落.     

海森堡XYZ自旋链系统的热纠缠与局域量子不确定性研究

研究了热平衡温度,自旋交换相互作用,Dzyaloshinskii-Moriya(DM)相互作用及外加非一致性磁场对两比特海森堡XYZ自旋链量子系统的热纠缠与局域量子不确定度的影响,对比分析了并发度量子纠缠与局域量子不确定度描述自旋链系统量子关联的差别.结果表明自旋链系统的量子纠缠在热平衡温度,DM相互作用及外加磁场的非一致性参数的变化情况下均会出现纠缠突然死亡的再生现象,而自旋链系统的局域量子不确定度随着这些参数呈连续变化现象.并且,自旋交换相互作用,DM相互作用及外加横向磁场作用强度较小时,他们的变化对自旋链系统的量子纠缠与局域量子不确定度的影响有着明显的差别.     

Association of UCP3, APN,and TNF-a Gene Polymorphisms with Type 2 Diabetes in a Population of Northern Chinese Han Patients

We observed the polymorphism distribution and coaction of uncoupling protein 3(UCP3)-55C/T,adiponectin(APN)+45T/G and tumor necrosis factor(TNF)-a-308G/A on the onset and development of T2DM in a North...     

Thermal Entanglement of an XY Two-Qutrit Spin Chain with Dzialoshinski-Moriya Interaction

The effect of Dzialoshinski-Moriya （DM） interaction on thermal entanglement of an XY two-qutrit spin chain is investigated. We find that DM interaction and the anisotropy parameter can enhance quantum thermal entanglement to a maximal value individually. However, when both of them take large values, the entanglement is not enhanced, but is destroyed. Our analysis will shed some light on the understanding of the effect of the DM interaction on thermal entanglement of an XY two-qutrit spin chain.     

基于DM642的运动目标实时跟踪监控系统的设计

针对视频监控中的运动目标,引入自主跟踪思想,设计了一种基于DSP的运动目标实时跟踪监控系统。系统以TI公司的DSPTMS320DM642为核心,采用改进的差分算法辅以二值化形态学处理进行运动检测,并通过速度归一化求取云台转动矢量,应用于变速云台系统,实现了对运动目标的自主稳定跟踪。实验证明,系统取得了良好的跟踪效果,保证了目标跟踪的自主性、准确性和实时性。     

基于双TMS320DM642处理器的实时红外多目标图像处理系统

按照模块化设计理念,提出以TMS320DM642芯片为核心器件的实时红外多目标图像处理系统的设计方案,结合现场可编程门阵列FPGA完成对红外焦平面探测器输出图像数据流的实时采集、处理和输出。采用两级级联方式对多目标图像并行处理,提高图像处理的实时性。实验表明该系统处理一帧320×240分辨率的图像平均需要耗时15 ms,保证了对多目标跟踪的实时性。     

红外与可见光图像融合的小型实时DSP平台实现

综合利用并实时处理红外与可见光图像的互补优势信息,设计实现了一种新型的以TMS320DM642——适合视频和图像处理的高性能定点DSP为核心的嵌入式硬件平台,可编程验证多种双波段图像融合算法。叙述了系统的结构设计和工作流程,板卡各关键组成单元的功能、原理,功耗计算,高频电路设计。介绍了系统的软件流程,包括初始化程序、驱动程序和融合应用程序的实现方法。结果表明,此高速、小型、低功耗的硬件平台可应用于便携式独立工作的双波段图像融合装置中。     

FEL数值模拟研究——解光场方程的谱方法

讨论了用三维自由空间的本征模,G-H(Gauss-Hermite)模,逼近光场方程解析解的方法。根据G-H模自身的特点和物理要求,估计出需要计算的模的个数m、n是不大的。同时,由于方法的特点,可以作到:(1)模拟电子数同差分法相比可以减少近两个量级;(2)电子方程和各阶G-H模都可以完全并行计算。