排序方式: 共有24条查询结果,搜索用时 15 毫秒
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M. del Carmen Núñez Fernando Rodríguez-Serrano Antonia Aránega Antonio Espinosa 《Tetrahedron》2005,61(43):10363-10369
On the basis of molecular variations on isosteric replacements from the prototype 1-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-5-fluorouracil a series of 3-(2,3-dihydro-5H-4,1-benzoxathiepin-3-yl)-uracil or -thymine O,N-acetals was prepared. The nature of the cis- and trans-sulfoxide isomers was established by means of their conformational analyses carried out with Sybyl and after comparing the theoretical results with the 1H NMR responses of the target molecules. (RS)-3-(1,1-Dioxo-2,3-dihydro-5H-4,1-benzoxathiepin-3-yl)thymine and (1S*,3S*)-1-(1-oxo-3,5-dihydro-2H-4,1-benzoxathiepin-3-yl)thymine were found to be inhibitors of the MCF-7 cell growth. 相似文献
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具有图象处理功能的激光荧光内窥系统的研究 总被引:3,自引:1,他引:2
内窥镜荧光图象系统是体腔内早期肿瘤诊断和定位的有效手段.但是早期开发研究的LFE荧光成家系统由于存在假阳性和假阴性误诊而限制了它的广泛开展和应用.本文仔细探讨了该系统产生误诊的原因,并在此基础上提出了使用计算机图象处理技术的荧光图象系统,而且通过实验验证了这种新技术,它能有效地克服假阳性和假阴性误诊,为体腔内肿瘤的诊断提供可靠判据. 相似文献
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Nobito Yamamoto Mitsuhiro T. Nakao Yoshitaka Watanabe 《Numerical Functional Analysis & Optimization》2013,34(11):1190-1204
We give a theoretical result with respect to numerical verification of existence and local uniqueness of solutions to fixed-point equations which are supposed to have Fréchet differentiable operators. The theorem is based on Banach's fixed-point theorem and gives sufficient conditions in order that a given set of functions includes a unique solution to the fixed-point equation. The conditions are formulated to apply readily to numerical verification methods. We already derived such a theorem in [11], which is suitable to Nakao's methods on numerical verification for PDEs. The present theorem has a more general form and one may apply it to many kinds of differential equations and integral equations which can be transformed into fixed-point equations. 相似文献
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This paper presents a novel computer aided technique for measurement of melanoma depth of invasion. Melanoma is the deadliest form of skin cancer with worldwide increasing incidences. For a conclusive diagnosis of melanoma, skin biopsies should be examined under a microscope. Visual inspection of microscopic samples is often subjective, time-consuming, cumbersome and prone to human errors. This fact demonstrates the necessity of developing an automated method which assists pathologists in evaluating histopathological samples more accurately in the busy clinical environment. To the best of our knowledge, this is the first time that a computer-assisted diagnosis algorithm has been applied in measurement of melanoma invasion depth. The proposed method uses a clustering algorithm for granular layer extraction and a pre-trained SVM classifier for detection of malignant melanocytes. The experimental results with average error of 3.9 μm demonstrate that the proposed method is reliable and effective. 相似文献
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本文介绍了计算机辅助反相高效液相色谱梯度洗脱优化分离的方法。首先采用混合设计法,通过9个预试验建立目标函数,然后运用双因素(初始流动相组成C和梯度时间T)扫描技术,由计算机给出优化分离条件,实验结果和预示完全一致。 相似文献
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Viewing the effective k-space coverage of MR images: phantom experiments with fast Fourier transform
The purpose of this experimental study was to evaluate whether the effective k-space coverage of MR images can in principle be viewed after multidimensional Fourier transform back to k-space. 相似文献
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Supercooling sperm in liquid nitrogen vapour is a feasible and economic technique for the practical production. The study aimed to reveal the negative effects of this rapid freezing and thawing processes on Taihang black goat spermatozoa and to find out the changing of spermatozoa motility and ultrastructure by using CASA and TEM. Qualified semen samples, which collected from twenty Chinese Taihang black goats using artificial vagina were pooled and investigated the kinematics parameters and ultrastructural morphology. The results showed that freezing–thawing caused a significant reduction in the spermatozoon total motility (P < 0.001), in rapid and medium cell numbers (P < 0.001) and motility parameters (VAP, VSL, VCL, ALH and BCF) (P < 0.01). Immotile spermatozoa number was increased significantly after freezing–thawing (P < 0.001). In the ultrastructural analysis, the shape with a sperm nucleus characterized by ruptures, bend and deformity was observed. The plasma membranes were broken, and nucleoplasm erupted. The mitochondria in the middle piece were disturbed by partial absence or additional accumulations. Swelling, coiling, vacuolization and structural disorganization of mitochondria were also observed. In conclusion, Freezing–thawing procedure has a detrimental effect on motility, membrane integrity and mitochondria of goat spermatozoa. Transmission electron microscopy provides an intuitive observation to investigate deformity spermatozoa. 相似文献
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Derivation of quantitative structure-activity relationships (QSAR) usually involves computational models that relate a set of input variables describing the structural properties of the molecules for which the activity has been measured to the output variable representing activity. Many of the input variables may be correlated, and it is therefore often desirable to select an optimal subset of the input variables that results in the most predictive model. In this paper we describe an optimization technique for variable selection based on artificial ant colony systems. The algorithm is inspired by the behavior of real ants, which are able to find the shortest path between a food source and their nest using deposits of pheromone as a communication agent. The underlying basic self-organizing principle is exploited for the construction of parsimonious QSAR models based on neural networks for several classical QSAR data sets. 相似文献