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Naohiro Hanyu Mamoru Hatakeyama Toshiyuki Tanaka Masaru Tada Adarsh Sandhu Masanori Abe Hiroshi Handa 《Journal of magnetism and magnetic materials》2009,321(10):1625-1627
For affinity purification of drug target protein we have developed magnetic carriers, narrow in size distribution (184±9 nm), which exhibit minimal non-specific binding of unwanted proteins. The carriers were highly dispersed in aqueous solutions and highly resistant to organic solvents, which enabled immobilization of various hydrophobic chemicals as probes on the carrier surfaces. Utilizing the carriers we have automated the process of separation and purification of the target proteins that had been done by manual operation previously. 相似文献
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