信息型常见毒物质谱用户库的建立及其在毒物快速筛选上的应用研究

质谱定性是目前世界上最通用的定性分析方法之一,在法庭科学领域毒物分析实践中,质谱一直是对未知样品进行药毒物筛选检测的利器.     

分子烙印聚合物吸附有机磷毒剂的研究

以有机磷毒剂沙林为烙印分子采用不同单体、交联剂有制孔剂制备了一系列分子烙印聚合物,从中筛选出了几种对沙林有很高吸附率（〉９０％）的聚合物。发现这些聚合物对沙林结构相近的其它有机磷毒剂如梭曼、塔崩及维爱克斯也有很好的吸附率。我们还考究了吸附率随时间变化的关系。     

脂质体免疫传感器的研究进展

综述了脂质体免疫传感器的工作原理和制备方法,探讨了脂质体免疫传感器在痕量物质分析检测中的应用和发展方向。     

Periodicity in a “Food-limited” Population Model with Toxicants and Time Delays

Abstract   With the help of a continuation theorem based on Gaines and Mawhin's coincidence degree, we study the global existence of positive periodic solutions of a “food-limited population model with toxicants and time delays. Some new results are obtained. Supported by the National Natural Sciences Foundation of China (No.10171010), the Key Project on Sciences and Technology of the Ministry of Education of China (No. Key 01061) and the Natural Sciences Foundation for Young Scholar of Northeast Normal University.     

Mass Spectrometry-Based Peptide Profiling of Haemolymph from Pterostichus melas Exposed to Pendimethalin Herbicide

Pendimethalin-based herbicides are used worldwide for pre-emergence selective control of annual grasses and weeds in croplands. The endurance of herbicides residues in the environment has an impact on the soil biodiversity and fertility, also affecting non-target species, including terrestrial invertebrates. Carabid beetles are known as natural pest control agents in the soil food web of agroecosystems, and feed on invertebrates and weed seeds. Here, a mass spectrometry untargeted profiling of haemolymph is used to investigate Pterostichus melas metabolic response after to pendimethalin-based herbicide exposure. Mass spectrometric data are examined with statistical approaches, such as principal component analysis, for possible correlation with biological effects. Those signals with high correlation are submitted to tandem mass spectrometry to identify the associated biomarker. The time course exposure showed many interesting findings, including a significant downregulation of related to immune and defense peptides (M-lycotoxin-Ls4a, Peptide hormone 1, Paralytic peptide 2, and Serine protease inhibitor 2). Overall, the observed peptide deregulations concur with the general mechanism of uptake and elimination of toxicants reported for Arthropods.     

常压电离质谱在公共安全化学毒物检测的应用

常压电离质谱技术(Ambient ionization mass spectrometry,AIMS)以其敞开式环境、简便操作、原位、实时、高通量等优势,成为公共安全化学毒物检测领域的研究热点.该文基于文献计量分析,简要概述了AIMS的分类、发展趋势及其在公共安全化学毒物检测领域的发展现状,重点从检测灵敏度、样品前处理...     

Periodicity in a “Food-limited” Population Model with Toxicants and Time Delays

Abstract With the help of a continuation theorem based on Gaines and Mawhin's coincidence degree,westudy the global existence of positive periodic solutions of a "food-limited" population model with toxicants andtime delays.Some new results are obtained.