药物相互作用及其临床意义

介绍了药物相互作用的概况和药物在药物动力学方面、药效学及在体外相互作用的一些临床表现.特别是因药物相互作用而引起的药物不良反应问题应引起注意。     

Recent progress in the chemistry of heterocycles incorporated oxazolo[4,5-b]pyridine and oxazolo[5,4-b]pyridine skeletons

Abstract

The present study describes recent advances in the chemistry of heterocycles incorporated oxazolo[4,5-b]pyridine and oxazolo[5,4-b]pyridine skeletons. The main sections included the synthesis of the investigated compounds from readily accessible aminopyridinol derivatives or aminopyridines. The reactivity of substituents attached to ring carbon or nitrogen atoms were discussed. In addition, the synthetic and biological evaluation of the inspected oxazolopyridines were highlighted. The purpose of this review is to discuss the chemistry of the title so far. The present study will support researchers in the fields of organic and medicinal chemistry to design and develop new protocols for the construction of new biological components.     

Assessing the ability of chemical similarity measures to discriminate between active and inactive compounds

Summary A method for assessing the biological discriminating power of chemical similarity measures is presented. The main concern of this work was to develop an objective way of evaluating different similarity measures in terms of how well they distinguished between active and inactive compounds. In addition, we have explored the level of similarity required for optimal separation and commented on its implications for work in the field of chemical diversity studies. The results for one simple similarity measure showed that statistically significant separation could be achieved, and indicated a reasonable similarity value for future work.     

谈谈温度的概念

本文基于对温度概念新的教学要求，阐述了温度概念的建立及其物理意义，并以现代的观点对温度概念的延伸作了初浅的讨论．     

随机DEA期望值模型的一些性质

为判别决策单元在随机DEA期望值模型下的随机有效性,首次提出了随机期望无效、随机期望弱有效、随机期望有效以及随机期望超有效的概念．并给出了三个命题用于判别不同显著性水平下随机期望效率与期望效率的关系．在此基础上,得到了两个重要的性质：（1）当期望效率保持不变时,随机期望效率为显著性水平的增函数;（2）当显著性水平保持不变时,随机期望效率为期望效率的增函数．最后,利用随机模拟和一个算例对上述结论进行了验证．     

浅析相关系数的显著性检验

本文用最小二乘法作直线拟合,给出相关系数显著性检验的判断方法,指出了用概率理论判断线性相关的必要性。     

Better bases for radial basis function interpolation problems

Radial basis function interpolation involves two stages. The first is fitting, solving a linear system corresponding to the interpolation conditions. The second is evaluation. The systems occurring in fitting problems are often very ill-conditioned. Changing the basis in which the radial basis function space is expressed can greatly improve the conditioning of these systems resulting in improved accuracy, and in the case of iterative methods, improved speed, of solution. The change of basis can also improve the accuracy of evaluation by reducing loss of significance errors. In this paper new bases for the relevant space of approximants, and associated preconditioning schemes are developed which are based on Floater’s mean value coordinates. Positivity results and scale independence results are shown for schemes of a general type. Numerical results show that the given preconditioning scheme usually improves conditioning of polyharmonic spline and multiquadric interpolation problems in R² and R³ by several orders of magnitude. The theory indicates that using the new basis elements (evaluated indirectly) for both fitting and evaluation will reduce loss of significance errors on evaluation. Numerical experiments confirm this showing that such an approach can improve overall accuracy by several significant figures.     

高阶各向同性张量的搜求方法

基于单位张量是唯一带有根本性意义的二阶各向同性张量的结论,系统推演搜求高阶各向同性张量的具体方法.