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排序方式: 共有3562条查询结果,搜索用时 15 毫秒
1.
Fernando Bento Cunha Karina Torres Pomini Ana Maria de Guzzi Plepis Virgínia da Conceio Amaro Martins Eduardo Gomes Machado Renato de Moraes Marcelo de Azevedo e Souza Munhoz Michela Vanessa Ribeiro Machado Marco Antonio Hungaro Duarte Murilo Priori Alcalde Daniela Vieira Buchaim Rogrio Leone Buchaim Victor Augusto Ramos Fernandes Eliana de Souza Bastos Mazuqueli Pereira Andr Antonio Pelegrine Marcelo Rodrigues da Cunha 《Molecules (Basel, Switzerland)》2021,26(6)
Autologous bone grafts, used mainly in extensive bone loss, are considered the gold standard treatment in regenerative medicine, but still have limitations mainly in relation to the amount of bone available, donor area, morbidity and creation of additional surgical area. This fact encourages tissue engineering in relation to the need to develop new biomaterials, from sources other than the individual himself. Therefore, the present study aimed to investigate the effects of an elastin and collagen matrix on the bone repair process in critical size defects in rat calvaria. The animals (Wistar rats, n = 30) were submitted to a surgical procedure to create the bone defect and were divided into three groups: Control Group (CG, n = 10), defects filled with blood clot; E24/37 Group (E24/37, n = 10), defects filled with bovine elastin matrix hydrolyzed for 24 h at 37 °C and C24/25 Group (C24/25, n = 10), defects filled with porcine collagen matrix hydrolyzed for 24 h at 25 °C. Macroscopic and radiographic analyses demonstrated the absence of inflammatory signs and infection. Microtomographical 2D and 3D images showed centripetal bone growth and restricted margins of the bone defect. Histologically, the images confirmed the pattern of bone deposition at the margins of the remaining bone and without complete closure by bone tissue. In the morphometric analysis, the groups E24/37 and C24/25 (13.68 ± 1.44; 53.20 ± 4.47, respectively) showed statistically significant differences in relation to the CG (5.86 ± 2.87). It was concluded that the matrices used as scaffolds are biocompatible and increase the formation of new bone in a critical size defect, with greater formation in the polymer derived from the intestinal serous layer of porcine origin (C24/25). 相似文献
2.
Sajeesh Kumar Madhurakkat Perikamana Sang Min Lee Jinkyu Lee Taufiq Ahmad Min Suk Lee Hee Seok Yang Heungsoo Shin 《Macromolecular bioscience》2019,19(4)
Plant derived flavonoids have not been well explored in tissue engineering applications due to difficulties in efficient formulations with biomaterials for controlled presentation. Here, the authors report that surface coating of epigallocatechin gallate (EGCG) on polymeric substrates including poly (L‐lactic acid) (PLLA) nanofibers can be performed via oxidative polymerization of EGCG in the presence of cations, enabling regulation of biological functions of multiple cell types implicated in bone regeneration. EGCG coating on the PLLA nanofiber promotes osteogenic differentiation of adipose‐derived stem cells (ADSCs) and is potent to suppress adipogenesis of ADSCs while significantly reduces osteoclastic maturation of murine macrophages. Moreover, EGCG coating serves as a protective layer for ADSCs against oxidative stress caused by hydrogen peroxide. Finally, the in vivo implantation of EGCG‐coated nanofibers into a mouse calvarial defect model significantly promotes the bone regeneration (61.52 ± 28.10%) as compared to defect (17.48 ± 11.07%). Collectively, the results suggest that EGCG coating is a simple bioinspired surface modification of polymeric biomaterials and importantly can thus serve as a promising interface for tuning activities of multiple cell types associated with bone fracture healing. 相似文献
3.
托卡马克工程试验混合堆等离子体性能的等值线图分析 总被引:3,自引:3,他引:0
盛光昭 《核聚变与等离子体物理》1989,9(1):29-36
本文简要叙述托卡马克工程试验混合堆等离子体概念设计的物理基础,对等离子体性能进行了等值线图(Plasma Operation Contour)分析。根据工程试验混合堆的要求,得出一组等离子体参数。 相似文献
4.
Relying on reliability growth testing to improve system designis neither usually effective nor efficient. Instead it is importantto design in reliability. This requires models to estimate reliabilitygrowth in the design that can be used to assess whether goalreliability will be achieved within the target timescale forthe design process. Many models have been developed for analysisof reliability growth on test, but there has been much lessattention given to reliability growth in design. This paperdescribes and compares two models: one motivated by the practicalengineering process; the other by extending the reasoning ofstatistical reliability growth modelling. Both models are referencedin the recently revised edition of international standard IEC61164. However, there has been no reported evaluation of theirproperties. Therefore, this paper explores the commonalitiesand differences between these models through an assessment oftheir logic and their application to an industrial example.Recommendations are given for the use of reliability growthmodels to aid management of the design process and to informproduct development. 相似文献
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6.
J.-L. Hainaut V. Englebert J. Henrard J.-M. Hick D. Roland 《Applied Categorical Structures》1996,3(1-2):9-45
This paper analyzes the requirements that CASE tools should meet for effective database reverse engineering (DBRE), and proposes
a general architecture for data-centered applications reverse engineering CASE environments. First, the paper describes a
generic DBMS-independent DBRE methodology, then it analyzes the main characteristics of DBRE activities in order to collect
a set of desirable requirements. Finally, it describes DB-MAIN, an operational CASE tool developed according to these requirements.
The main features of this tool that are described in this paper are its unique generic specification model, its repository,
its transformation toolkit, its user interface, the text processors, the assistants, the methodological control and its functional
extensibility. Finally, the paper describes five real-world projects in which the methodology and the CASE tool were applied.
This is a heavily revised and extended version of “Requirements for Information System Reverse Engineering Support” by J.-L.
Hainaut, V. Englebert, J. Henrard, J.-M. Hick, D. Roland, which first appeared in the Proceedings of the Second Working Conference
on Reverse Engineering, IEEE Computer Society Press, pp. 136–145, July 1995. This paper presents some results of the DB-MAIN
project. This project is partially supported by the Région Wallonne, the European Union, and by a consortium comprising ACEC-OSI (Be), ARIANE-II (Be), Banque UCL (Lux), BBL (Be), Centre de recherche public H.
Tudor (Lux), CGER (Be), Cockerill-Sambre (Be), CONCIS (Fr), D'Ieteren (Be), DIGITAL, EDF (Fr), EPFL (CH), Groupe S (Be), IBM,
OBLOG Software (Port), ORIGIN (Be), Ville de Namur (Be), Winterthur (Be), 3 Suisses (Be). The DB-Process subproject is supported
by the Communauté Fran?aise de Belgique. 相似文献
7.
8.
9.
Editorial: Metal-Enhanced Fluorescence 总被引:1,自引:0,他引:1
10.
用于曲面精密检测的新型光纤三角传感器研究 总被引:1,自引:1,他引:0
基于光纤传感技术和三角测量方法,提出了一种用于曲面检测的新型光纤三角传感器。根据所设计的轮辐式接收光纤结构,可以在测量曲面与传感头间位移时,首先获取被测点处微面元的倾斜信息,以便对传感器测量值进行实时误差修正,从而解决了被测表面倾斜对坐标测量带来的影响。该传感器还能有效地消除环境光干扰、光源波动、表面反射率变化等对测量带来的影响。建立了传感器测量的数学模型。理论分析和初步的实验结果证明了系统的有效性和实用性。该传感器系统不稳定性好于0.3%,横向分辨率好于8μm,高度分辨率好于0.1μm。 相似文献