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Functional Binding Surface of a β‐Hairpin VEGF Receptor Targeting Peptide Determined by NMR Spectroscopy in Living Cells 下载免费PDF全文
Dr. Donatella Diana Anna Russomanno Dr. Lucia De Rosa Dr. Rossella Di Stasi Dr. Domenica Capasso Dr. Sonia Di Gaetano Dr. Alessandra Romanelli Dr. Luigi Russo Dr. Luca D. D'Andrea Prof. Roberto Fattorusso 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(1):91-95
In this study, the functional interaction of HPLW peptide with VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) was determined by using fast 15N‐edited NMR spectroscopic experiments. To this aim, 15N uniformly labelled HPLW has been added to Porcine Aortic Endothelial Cells. The acquisition of isotope‐edited NMR spectroscopic experiments, including 15N relaxation measurements, allowed a precise characterization of the in‐cell HPLW epitope recognized by VEGFR2. 相似文献
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Cover Picture: Coordination Chemistry of N‐Heterocyclic Nitrenium‐Based Ligands (Chem. Eur. J. 19/2015) 下载免费PDF全文
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Prof. Dr. Frank Glorius 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(22):8047-8051
A general and efficient methodology for the direct transition metal free trifluoromethylthiolation of a broad range of biologically relevant N‐heteroarenes is reported employing abundant sodium chloride as the catalyst. This method is operationally simple, exhibits high functional group tolerance, and does not require protecting groups. 相似文献
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Peter Dräxler 《Journal of Pure and Applied Algebra》2002,169(1):33-42
We show that the cleaving functors introduced in [Bautista et al., Invent. Math. 81 (1985) 217] as a tool for proving infinite representation type of finite-dimensional algebras can also be used to establish controlled wildness. The main application is that an algebra is controlled wild if there is an indecomposable projective module with a Loewy factor having a homogeneous direct summand which is of length at least 3. As a second application we derive Han's covering criterion. 相似文献
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We build a metric space which is homeomorphic to a Cantor set but cannot be realized as the attractor of an iterated function system. We give also an example of a Cantor set K in R3 such that every homeomorphism f of R3 which preserves K coincides with the identity on K. 相似文献
10.
A Volterra type integral equation in a Hilbert space with an additional linear operator L and a spectral parameter depending
on time is considered. If the parameter does not belong to the spectrum of L unconditional solvability of the considered problem
is proved. In the case where the initial value of the parameter coincides with some isolated point of the spectrum of the
operator L sufficient conditions for solvability are established. The obtained results are applied to the partial integral
equations associated with a contact problem of the theory of elasticity. 相似文献