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排序方式: 共有379条查询结果,搜索用时 31 毫秒
1.
It is well known that the mathematical models provide very important information for the research of human immunodeficiency virus-type 1 and hepatitis C virus (HCV). However, the infection rate of almost all mathematical models is linear. The linearity shows the simple interaction between the T cells and the viral particles. In this paper, we consider the classical mathematical model with saturation response of the infection rate. By stability analysis we obtain sufficient conditions on the parameters for the global stability of the infected steady state and the infection-free steady state. We also obtain the conditions for the existence of an orbitally asymptotically stable periodic solution. Numerical simulations are presented to illustrate the results. 相似文献
2.
Z. Mukandavire W. Garira C. Chiyaka 《Journal of Mathematical Analysis and Applications》2007,330(2):916-933
A mathematical model for HIV/AIDS with explicit incubation period is presented as a system of discrete time delay differential equations and its important mathematical features are analysed. The disease-free and endemic equilibria are found and their local stability investigated. We use the Lyapunov functional approach to show the global stability of the endemic equilibrium. Qualitative analysis of the model including positivity and boundedness of solutions, and persistence are also presented. The HIV/AIDS model is numerically analysed to asses the effects of incubation period on the dynamics of HIV/AIDS and the demographic impact of the epidemic using the demographic and epidemiological parameters for Zimbabwe. 相似文献
3.
艾滋病防治资源投入的效果分析 总被引:1,自引:1,他引:0
基于GOALS模型的基本思想,建立了效果分析模型,并针对两种不同的资金分配方案,模拟了两种方案对2006—2010年某地艾滋病流行的影响,并对模拟结果进行了分析. 相似文献
4.
Wei‐Lie Xiao Jian‐Xin Pu Rui‐Rui Wang Liu‐Meng Yang Xiao‐Li Li Sheng‐Hong Li Rong‐Tao Li Sheng‐Xiong Huang Yong‐Tang Zheng Han‐Dong Sun 《Helvetica chimica acta》2007,90(8):1505-1513
Seven new highly oxygenated nortriterpenoids, rubriflorins D–J ( 1 – 7 ), were isolated from the leaves and stems of Schisandra rubriflora, and their structures were elucidated on the basis of extensive analysis of spectroscopic data. These new compounds feature the opening of ring A compared with related known nortriterpenoids isolated from the genus Schisandra and showed weak activity against HIV‐1. 相似文献
5.
Knudsen B Andersen ES Damgaard C Kjems J Gorodkin J 《Computational Biology and Chemistry》2004,28(3):219-226
Predicting RNA secondary structure using evolutionary history can be carried out by using an alignment of related RNA sequences with conserved structure. Accurately determining evolutionary substitution rates for base pairs and single stranded nucleotides is a concern for methods based on this type of approach. Determining these rates can be hard to do reliably without a large and accurate initial alignment, which ideally also has structural annotation. Hence, one must often apply rates extracted from other RNA families with trusted alignments and structures. Here, we investigate this problem by applying rates derived from tRNA and rRNA to the prediction of the much more rapidly evolving 5'-region of HIV-1. We find that the HIV-1 prediction is in agreement with experimental data, even though the relative evolutionary rate between A and G is significantly increased, both in stem and loop regions. In addition we obtained an alignment of the 5' HIV-1 region that is more consistent with the structure than that currently in the database. We added randomized noise to the original values of the rates to investigate the stability of predictions to rate matrix deviations. We find that changes within a fairly large range still produce reliable predictions and conclude that using rates from a limited set of RNA sequences is valid over a broader range of sequences. 相似文献
6.
HIV infection leads to progressive alterations of humoral immune functions, including B-cell hyperplasia, hypergammaglobulinemia,
elevated autoantibody titers, a poor response to neoantigens and mitogens, polyclonal B-cell activation, monoclonal gammopathies,
and a significant deterioration of the antigen-specific humoral response. There is also an important isotypic imbalance of
the antibody (Ab) response in the systemic compartment and a profound modification of mucosal immune functions. These abnormalities
may contribute to disease progression and development of opportunistic infections, despite the presence of serum-neutralizing
anti-HIV Abs. Equally important are the abnormal selection mechanisms of the Ab repertoire that seem to be responsible for
B-cell clonal deletions. The VH3 gene family, which encodes for approx 50% of immunoglobulins expressed by peripheral B-cells from normal adults, is underrepresented
in human monoclonal antibodies to HIV-1 and in the peripheral B-cells of AIDS patients. These abnormalities, together with
features of germinal center alteration, could be responsible for the clonal elimination of a subset of B-cells, and could
contribute to HIV pathogenesis. 相似文献
7.
Carlo Bonini Lucia Chiummiento Maria Funicello Gerardina Suanno Pietro Campaner 《Tetrahedron》2005,61(27):6580-6589
An efficient method has been developed for the synthesis of a versatile intermediate bearing azido, hydroxyl and ester functions, a useful precursor for peptidomimetic compounds. The two main features for this synthesis were the use of the Sharpless asymmetric dihydroxylation on thiophene acrylate and the subsequent regioselective ring opening by sodium azide of the cyclic sulfite. Highly chemoselective reduction of the azido alcohol led to a key compound which was utilized for the synthesis of two analogues of commercial anti HIV PR such as nelfinavir and saquinavir. The biological activity and molecular modelling study on these two new potential drugs have been evaluated. 相似文献
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