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A likelihood-based method for haplotype association studies of case-control data with genotyping uncertainty 总被引:1,自引:0,他引:1
ZHU Wensheng & GUO Jianhua School of Mathematics Statistics Northeast Normal University Changchun China 《中国科学A辑(英文版)》2006,49(1):130-144
This paper discusses the associations between traits and haplotypes based on Fl (fluorescent intensity) data sets. We consider a clustering algorithm based on mixtures of t distributions to obtain all possible genotypes of each individual (i.e. "GenoSpec-trum"). We then propose a likelihood-based approach that incorporates the genotyping uncertainty to assessing the associations between traits and haplotypes through a haplotype-based logistic regression model. Simulation studies show that our likelihood-based method can reduce the impact induced by genotyping errors. 相似文献
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