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1.
Alex H. F. Lee Jian Chen Albert S. C. Chan Tianhu Li 《Phosphorus, sulfur, and silicon and the related elements》2013,188(5):1163-1174
5-(7-Hydroxyheptyl)-1,2-dithiolan-3-one 1-oxide was designed and synthesized in our laboratories that contain the heterocycle of 1,2-dithiolan-3-one 1-oxide, a reactive core of antibiotic leinamycin. In addition, the activated ester of 5-(7-hydroxyheptyl)-1,2-dithiolan-3-one 1-oxide was prepared, which presumably is useful for coupling this DNA-cleaving functionality to certain DNA-binding agents. 相似文献
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WU Ren-Ping YU Yan GU Ying Yun GUO Jin-Yu 《结构化学》2007,26(5):562-566
Deep color glass-ceramics is prepared by using gold tailings as the main raw material, and Cr2O3 is added as nucleation agent. Influence of different Cr2O3 additions on crystallization structure and properties of CaO-MgO-Al2O3-SiO2 glass-ceramics has been discussed so as to select optimum additions. DTA is employed to determine optimum crystallization and nucleation temperatures; XRD and SEM are used to characterize microstructure of each sample; and performance indexes, such as water absorption, bulk density, flexural strength and so on, are also determined. Experimental results show that when 3wt% Cr2O3 is introduced, fine glass-ceramics with diopside as the main crystal and Ca-Fe diopside as the second-crystal is obtained, and its corresponding performance indexes are as follows: water absorption 0.12%, bulk density 2.56 g/cm3, and flexural strength 70.01 Mpa. 相似文献
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Federico Scaravelli Sergio Bacchi Ornella Curcuruto William Maton 《Tetrahedron letters》2010,51(39):5154-5156
An efficient and versatile synthetic method is described to synthesize diethylphosphonacetamides in a single step. 相似文献
5.
Nicoleta Petrea Răzvan Petre Andrada Pretorian Constantin Toader Vasile Şomoghi Florentina Neaţu Mihaela Florea Ştefan Neaţu 《Comptes Rendus Chimie》2018,21(3-4):339-345
The catalytic methanolysis of the chemical warfare nerve agents soman, sarin, and VX was investigated by using Cu or Zn complexes. Although VX withstood decontamination, the decomposition yield being around 96%, the soman and sarin deposited on different surfaces were almost fully destroyed under ambient conditions. The catalytic tests performed on a wide range of contaminated surfaces confirm the activity of the investigated catalytic systems, these complexes being suitable, from an economical point of view, for use in the formulation of a possible decomposition kit with military or civilian applicability. 相似文献
6.
Ivarsson ME Leroux JC Castagner B 《Angewandte Chemie (International ed. in English)》2012,51(17):4024-4045
Protein toxins constitute the main virulence factors of several species of bacteria and have proven to be attractive targets for drug development. Lead candidates that target bacterial toxins range from small molecules to polymeric binders, and act at each of the multiple steps in the process of toxin-mediated pathogenicity. Despite recent and significant advances in the field, a rationally designed drug that targets toxins has yet to reach the market. This Review presents the state of the art in bacterial toxin targeted drug development with a critical consideration of achieved breakthroughs and withstanding challenges. The discussion focuses on A-B-type protein toxins secreted by four species of bacteria, namely Clostridium difficile (toxins A and B), Vibrio cholerae (cholera toxin), enterohemorrhagic Escherichia coli (Shiga toxin), and Bacillus anthracis (anthrax toxin), which are the causative agents of diseases for which treatments need to be improved. 相似文献
7.
Ahmed I. Khodair 《Phosphorus, sulfur, and silicon and the related elements》2013,188(5):1157-1173
A variety of novel 5-[( Z )-arylidene]-2-[(2-( E )-arylidene)hydrazono]-4-imidazolidinones 1a-c to 4a , b and 5-[( Z )-arylidene]-2-[(2-( E )-polyhydroxyalkylidene)hydrazono]-4-imidazolidinones 5a-c to 7a-c were prepared from the reaction of 5-[( Z )-arylidene]-2-methylmercaptohydantoins 8a-c with 2-( E )-arylidene hydrazones 13a-d and/or 2-( E )-monosaccharides hydrazones 16a-c . The linear structure, and not that of the angular isomer, has been selected for the products. This structure has been confirmed from a model study of the condensation of 5-[( Z )-2-thienylidene]-2-hydrazono-4-imidazolidinone 9a with benzaldehyde and D -galactose, respectively. The acetylation and benzoylation reactions of compounds 1-7 have been studied. All the new compounds were tested for their potential antiviral and antitumor activities. 相似文献
8.
《Analytical letters》2012,45(16):1297-1309
Abstract The influence of some precipitating and complexing agents on the function of Pb(II)-sensitive electrode was studied. On the basis of the experimental findings, procedures were worked out for determining oxalate, phosphate, chromate, nitrilotriacetic acid (NTA), sodium diethyldithiocarbamate (NaDDC), and diethylenetetraamine penta-acetic acid (DTPA) with a standard Pb(II) solution as a titrant and a Pb(II), -sensitive electrode as a detector. The reverse titration of Pb(II), with any of these agents could also be done. 相似文献
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The X-ray crystal structures of 4,4-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (I) and 2,2-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (II) have been determined in order to study the structural characteristics of these molecules that may contribute to their antiestrogenic and cytotoxic properties. These structures have been compared to other hydrazone derivatives as well as tamoxifen, an antiestrogen drug presently used clinically for the treatment of breast cancer.Crystal data: (I) C19H14N4O6 · C4H10O; MW=468.0; monoclinic,P21;a=8.601(2), b=15.502(8), c=16.851(4) Å,=98.58(2)°;Z=8; finalR=0.036 for 1904 observed reflections. (II C19H14N4O6 · H2O; MW=410.0; monoclinic,P21/c;a=7.603(2),b=19.552(4),c=12.493(3) Å,=92.11(1)°;Z=4; finalR=0.045 for 1171 observed reflections. 相似文献
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Ye Gong Rui Liu Hongjing Zha Ding Dong Dr. Nihong Lu Hui Yan Dr. Luosheng Wan Dr. Yin Nian 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2024,136(1):e202313461
Low-voltage-gated calcium channels (LVGCCs; Cav3.1-3.3) represent promising drug targets for epilepsy, pain, and essential tremor. At present, modulators with heightened selectivity for a subtype of LVGCCs are still highly desired. In this study we explored three classes of Buxus alkaloids and identified 9(10/19)abeo-artanes Buxusemine H and Buxusemine L (BXSL) as an unprecedented type of Cav3.2 inhibitors. Particularly, BXSL exhibited Cav3.2 inhibition comparable to Z944, a non-subtype-selective LVGCCs inhibitor under clinical trial. While lacking specificity for Cav3.3, BXSL showed a 30-fold selectivity of Cav3.2 over Cav3.1. As compared to several well-known inhibitors, the experimental and computational studies suggested BXSL exhibits a distinct binding mode to Cav3.2, notably through the essential interaction with serine-1543 in domain III. Furthermore, BXSL showed minimal impact on various recombinant and native nociceptive ion channels, while significantly reducing the excitability of isolated mouse dorsal root ganglion neurons. Animal studies in wild-type and Cav3.2 knock-out mice revealed that BXSL (5 mg/kg), by inhibiting Cav3.2, exhibits an analgesic effect equivalent to Z944 (10 mg/kg) or mibefradil (10 mg/kg). Moreover, we proposed a structural rationale for the high selectivity of 9(10/19)abeo-artane-type alkaloids towards Cav3.2 over Cav3.1. This study introduces a novel analgesic agent and valuable molecular insight for structure-based innovative Cav3.2 drug development. 相似文献