BP网络光度法测定去痛片中的四组分

应用Levenberg-Marquardt优化算法的BP网络,采用紫外分光光度法测定去痛片中四组分的含量。测定低含量组分咖啡因和苯巴比妥时,结合吸光度减法技术。氨基比林、非那西丁、咖啡因和苯巴比妥的平均回收率和RSD分别为99.3%,1.2%：;100.0%,1.1%;100.3%,1.5%;100.1%,1.3%。     

Micro-HPLC–UV analysis of cocaine and its adulterants in illicit cocaine samples seized by Austrian police from 2012 to 2017

The worldwide consumption of illicit drugs presents a big problem in terms of health care and prosecution. In the recent years, hundreds of novel psychoactive substances came up and were traded through the Internet, but there is still a big demand for classic illicit drugs such as cocaine, heroin, cannabis, and ecstasy. Among these, cocaine particularly is frequently altered not only with excipients but also with other physiologically active substances. The purpose of this work was to estimate the trend of cocaine purity and abundance of its adulterants in samples seized by Austrian police from 2012 to 2017. A micro-HPLC method for quantification of cocaine and its most common adulterants was developed and validated using gradient elution and UV detection at four wavelengths. A total of 110 cocaine samples were analyzed. In all the samples, cocaine was present as hydrochloric salt. Caffeine, procaine, levamisole, phenacetin, lidocaine, and benzocaine were the most abundant adulterants.     

改良型比光谱-导数分光光度法在四元混合体系同时测定中的应用

提出了可应用于四元混合体系同时测定的比光谱-导数分光光度法，阐述了该方法的基本原理，并将其应用于氨基比林、苯巴比妥、咖啡因和非那西丁四元混合体系中各组分的同时测定。结果表明，氨基比林、笨巴比妥、咖啡因和非那西丁的回收率分别是109．3％（RSD=4．3％）、102．4％（RSD=6．6％）、108.7％（RSD=5．1％）、98．62％（RSD=3．2％）。方法的准确度和精密度都可以满足四组分同时测定的要求，方法简单、快速。     

Model Analysis for Oral Absorption of a Drug/Cyclodextrin Complex Involving Competitive Inclusion Complexes

The bioavailability parameters of a drug after oral administration of a preparation containing drug/CyD complexes may be modified by formation of competitive inclusion complexes. In this study, we examined the effects of competitors on drug permeation from its CyD complex through in-vitro artificial membranes and in-situ recirculation conditions, for comparison with the results under in-vivo conditions in the bile duct of cannulated rats. Phenacetin, an antipyretic, was used as a model drug, natural CyDs and maltosyl--CyD as host molecules, and benzoic acid derivatives, sodium taurocholate and acetaminophen as competitors. The in-vitro cellophane membrane permeation rate and the in-situ absorption rate of phenacetin were quantitatively predicted by theoretical calculation using the stability constants of drug/CyD and competitor/CyD complexes when CyD weakly interacts with membrane components in lower CyD concentrations (generally below 10 mM). The in-vivo absorption behavior was only qualitatively reproducible by the theoretical calculation, probably because of various physicochemical and physiological factors affecting the absorption. The present results may be useful not only for prediction of intestinal absorption of drugs from CyD preparations, but also for formulation design of CyD preparations containing multi-components.     

复方解热镇痛药的毛细管胶束电动色谱快速分析

研究了用毛细管胶束电动色谱快速测定解热镇痛药复方阿司匹林（APC）中阿司匹林（AS）,非那西丁（PH）,咖啡因（CA）及复方扑热息痛（PAC）中扑息痛（PA）,AS,CA含量的方法,使用长37cm（有效长度30cm)内径75um的石英毛细管,＋20kV分离电压,在PH8．65的9mmol.L^-1Na2B4O7-13mmol.L^-1KH2PO4(内含60mmol.L^-1)SDSt 2%乙醇）缓冲溶液中,同一制剂中的三组分可在4．5min内完全分离,用紫外检测器在214nm处检测,外标法定量,测定4组分的相对标准偏差在0．84％－1．84％之间,回收率在99－104％之间,所建立的方法应用于复方阿司匹林片和复方扑热息痛片的成分分析,结果令人满意。     

非那西汀印迹聚合物固相萃取性能研究

研究非那西汀分子印迹聚合物的固相萃取性能。用本体聚合法制备非那西汀分子印迹聚合物,通过静态平衡吸附试验及固相萃取试验,研究其固相萃取性能。非那西汀模板聚合物的吸附能力明显强于空白聚合物。模板聚合物对浓度为0.03mmol/L的非那西汀标准溶液一次性萃取率为74.2%。非那西汀印迹聚合物对非那西汀具有特异性识别性能,可作为固相萃取固定相的应用研究。     

复方药物安痛定、阿斯匹林和克感敏片中非那西丁含量的分光光度法测定

非那西丁具有解热阵痛的作用 ,许多复方药物中均含有非那西丁 ,复方药物中非那西丁的测定方法报道较多 [1-3 ] ,地方药品标准中非那西丁含量测定多采用氯仿提取后 ,蒸干 ,残渣加稀硫酸回流 ,用含锌碘化钾淀粉作指示剂 ,用亚硝酸钠溶液滴定 [4] 。该方法操作繁琐、费时且终点不易判断 ,本文利用非那西丁在 1 mol· L-1盐酸介质中水解 ,水解产物被重络酸钾氧化为棕红色 ,在540 nm处有强吸收的原理 [5 ]测定其含量。该方法简便、快速 ,适合于单一组分中非那西丁的测定。1　方法与结果1 .1　主要仪器和试剂72 1分光光度计 (上海第三分析仪器厂 …     

Thermodynamic Characteristics of Phenacetin in Solid State and Saturated Solutions in Several Neat and Binary Solvents

The thermodynamic properties of phenacetin in solid state and in saturated conditions in neat and binary solvents were characterized based on differential scanning calorimetry and spectroscopic solubility measurements. The temperature-related heat capacity values measured for both the solid and melt states were provided and used for precise determination of the values for ideal solubility, fusion thermodynamic functions, and activity coefficients in the studied solutions. Factors affecting the accuracy of these values were discussed in terms of various models of specific heat capacity difference for phenacetin in crystal and super-cooled liquid states. It was concluded that different properties have varying sensitivity in relation to the accuracy of heat capacity values. The values of temperature-related excess solubility in aqueous binary mixtures were interpreted using the Jouyban–Acree solubility equation for aqueous binary mixtures of methanol, DMSO, DMF, 1,4-dioxane, and acetonitrile. All binary solvent systems studied exhibited strong positive non-ideal deviations from an algebraic rule of mixing. Additionally, an interesting co-solvency phenomenon was observed with phenacetin solubility in aqueous mixtures with acetonitrile or 1,4-dioxane. The remaining three solvents acted as strong co-solvents.     

The Morphology of Etch Pits During Thermal Treatment of Drugs and its Dependence on the Features of Their Crystallochemical Structure

Topochemistry of the initial stages of evaporation and dissolution of monoclinic single crystals of paracetamol and phenacetin was studied. Thermal treatment of these crystals showed that the morphology of etch pits depicts the symmetry of etched planes. The shapes of pits formed during chemical etching of the cleavage plane of a paracetamol crystal by different etchants were not similar to each other. The chemical etching of the cleavage plane of a phenacetin crystal resulted in the formation of pits stretched along the same direction, independently of the chosen solvent. An interpretation of this result is suggested, based on the analysis of the anisotropy of the crystal structure and presence of steric hindrance.This revised version was published online in November 2005 with corrections to the Cover Date.