地面附近的高空核爆电磁脉冲环境

 主要研究在高空核爆的双指数类型电磁脉冲平面波入射时，地面附近的电磁脉冲环境。计算给出了在不同入射波状态，不同地表介质电气特性和距地面不同高度等条件下的电磁脉冲环境参数，归纳了一些规律性认识。结果显示：地面附近的电场会随距地面高度的不同而发生显著的变化，对于水平场分量，其反射场总是试图抵消入射场，而对于垂直场分量，其反射场叠加在入射场上，使得地面附近的垂直场强幅值一般大于入射波场强幅值；当入射波仰角增大时，合成电场波形的脉冲宽度会变宽；地表介质的电气特性参数不同也会对地面附近电场的波形和幅值造成一定的影响。     

On locating low altitude moving targets using a planar acoustic sensor array

It is of engineering importance to locate low altitude moving targets with acoustic methods due to the blindness of the traditional radar detecting. In this paper, an algorithm for locating low altitude moving targets is put forward based on a five-element planar acoustic sensor array. The method is realized through estimations of the sensor-to-sensor time delays of the source signal generated by the low altitude moving target. The angle and range estimation performance of the proposed method are analyzed, respectively, both in theoretical and numerical sense.     

临近空间高空气球地基探测能力分析

基于探测系统背景辐射特性及高空气球辐射特性,建立了探测系统辐射接收模型.考虑大气传输、光学系统成像、探测器及其采样对辐射的影响,精确计算了高空气球辐射及背景辐射在探测器焦平面阵列上产生的信号电子数,推导出用于高空气球探测的信噪比.利用Modtran软件仿真计算了自身辐射、镜背景辐射、漫背景辐射亮度,分析了复杂大气条件下的气球辐射特性,及高空气球镜反射率、漫反射率与积分时间对探测系统信噪比的影响.结果表明:采用光谱滤波技术,在晴朗无云天气下,可见光近红外(0.6~2.4)探测器适合高空气球探测;在复杂大气条件下,长波红外(8~12)探测器适合高空气球探测;在积分时间为0.25s,镜反射率为0.32,漫反射率为0.68时,或积分时间为1s,镜反射率0.43,漫反射率0.57时,探测系统对高空气球探测能力最强.     

无人机视角下的林木爆燃火特性研究

森林火灾“爆燃”现象的特征是突然发生的高强度、高蔓延速度的燃烧。目前为止，关于“爆燃火”的原因还没有达成共识。以无人机视角下对林木爆燃火特性研究，以四川木里特大森林火灾为研究对象，通过分析凉山州某森林扑火部队3月31日木里森林火灾当天KWT（科卫泰）无人机航拍火场画面，结合无人机实时影像及实地调研数据，分析了峡谷地形林火蔓延时空特征，探讨了峡谷中风向风速变化时空分布规律，研究了地形变化条件下，不同海拔高度风速特征，建立了无人机倾角测量风速模型（其中为风速m·s-1，为无人机倾角°）。结果表明，高山峻岭特殊地形环境下每天4:00—12:00时间段为静风期，为峡谷林火扑救最佳时期；午后15:00—17:00和晚上20:00—22:00为山谷地形风速活跃期；仿真软件数据显示山顶、谷底与山腰不同海拔位置的风速风向不统一，谷底会产生乱流现象，且风速与海拔不存在正相关关系，小气候在复杂地形中占主导影响地位；在谷口至山谷深处的中间位置会出现气流速度的波峰状态，并易形成乱流，为爆燃火发生提供了客观必要条件。该研究可为复杂地形环境下，森林草原火灾扑救安全提供数据和技术支撑。     

山区智能视觉火情高空图像搜集系统的设计与实现

介绍了一种针对山区多样性突发火情事件中基于智能视觉的高空图像搜集系统,采用以ST意法半导体公司的STM32F107VCT6为处理核心的开发平台,地面控制平台通过高空无人机的高速照相机对目标区域火情图像数据进行搜集,并将图像数据带回到地面控制平台的PC处理器上进行综合分析。地面控制平台根据智能视觉信息采集模块采集的山区遥感图像的均值作为初始背景,并对背景图像进行实时更新,利用光谱特征与距离算法获取差分图像,并进行图像处理,从而获取山区发生火情区域的图像分析数据,以实现对山区森林突发火情事件的及时监测,在火情发生初始阶段就能扑灭。本文对山区智能视觉火情高空搜集系统的实现原理、核心硬件设计、系统软件设计等分别进行了研究,并通过系统实验进行了验证,测试结果表明,该系统在对山区的高空图像搜集实验中,对不同颜色物体的分别识别率为100%,对火灾与地形地貌的识别率为95.55%和81.12%,非常适用于各种山区环境下的智能视觉监控系统。     

Monochromophore-Based Phosphorescence and Fluorescence from Pure Organic Assemblies for Ratiometric Hypoxia Detection

Hypoxia is a parameter related to many diseases. Ratiometric hypoxia probes often rely on a combination of an O₂-insensitive fluorophore and an O₂-sensitive phosphor in a polymer matrix, which require high cost and multi-step synthesis of transition metal complexes. The two-chromophore hypoxia probes encounter unfavorable energy transfer processes and different stabilities of the chromophores. Reported herein is a pure organic ratiometric hypoxia nanoprobe, assembled by a monochromophore, naphthalimide ureidopyrimidinone (BrNpA-UPy), bridged by a bis-UPy-functionalized benzyl skeleton. The joint factors of quadruple hydrogen bonding, the rigid backbone of UPy, and bromine substitution of the naphthalimide derivative facilitate bright phosphorescence (Φ_P=7.7 %, τ_P=3.2 ms) and fluorescence of the resultant nanoparticles (SNPs) at room temperature, which enable accurate, ratiometric, sensitive oxygen detection (K_sv=189.6 kPa⁻¹) in aqueous solution as well as in living HeLa cells.     

Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors

A facile approach to assemble catalase-like photosensitizing nanozymes with a self-oxygen-supplying ability was developed. The process involved Fe³⁺-driven self-assembly of fluorenylmethyloxycarbonyl (Fmoc)-protected amino acids. By adding a zinc(II) phthalocyanine-based photosensitizer (ZnPc) and the hypoxia-inducible factor 1 (HIF-1) inhibitor acriflavine (ACF) during the Fe³⁺-promoted self-assembly of Fmoc-protected cysteine (Fmoc-Cys), the nanovesicles Fmoc-Cys/Fe@Pc and Fmoc-Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly. The released Fe³⁺ could catalyze the transformation of H₂O₂ enriched in cancer cells to oxygen efficiently, thereby ameliorating the hypoxic condition and promoting the photosensitizing activity of the released ZnPc. With an additional therapeutic component, Fmoc-Cys/Fe@Pc/ACF exhibited higher in vitro and in vivo photodynamic activities than Fmoc-Cys/Fe@Pc, demonstrating the synergistic effect of ZnPc and ACF.     

Effects of Roxadustat on Erythropoietin Production in the Rat Body

Anemia is a major complication of chronic renal failure. To treat this anemia, prolylhydroxylase domain enzyme (PHD) inhibitors as well as erythropoiesis-stimulating agents (ESAs) have been used. Although PHD inhibitors rapidly stimulate erythropoietin (Epo) production, the precise sites of Epo production following the administration of these drugs have not been identified. We developed a novel method for the detection of the Epo protein that employs deglycosylation-coupled Western blotting. With protein deglycosylation, tissue Epo contents can be quantified over an extremely wide range. Using this method, we examined the effects of the PHD inhibitor, Roxadustat (ROX), and severe hypoxia on Epo production in various tissues in rats. We observed that ROX increased Epo mRNA expression in both the kidneys and liver. However, Epo protein was detected in the kidneys but not in the liver. Epo protein was also detected in the salivary glands, spleen, epididymis and ovaries. However, both PHD inhibitors (ROX) and severe hypoxia increased the Epo protein abundance only in the kidneys. These data show that, while Epo is produced in many tissues, PHD inhibitors as well as severe hypoxia regulate Epo production only in the kidneys.     

Tumor Hypoxia Heterogeneity Affects Radiotherapy: Inverse-Percolation Shell-Model Monte Carlo Simulations

Tumor hypoxia was discovered a century ago, and the interference of hypoxia with all radiotherapies is well known. Here, we demonstrate the potentially extreme effects of hypoxia heterogeneity on radiotherapy and combination radiochemotherapy. We observe that there is a decrease in hypoxia from tumor periphery to tumor center, due to oxygen diffusion, resulting in a gradient of radiative cell-kill probability, mathematically expressed as a probability gradient of occupied space removal. The radiotherapy-induced break-up of the tumor/TME network is modeled by the physics model of inverse percolation in a shell-like medium, using Monte Carlo simulations. The different shells now have different probabilities of space removal, spanning from higher probability in the periphery to lower probability in the center of the tumor. Mathematical results regarding the variability of the critical percolation concentration show an increase in the critical threshold with the applied increase in the probability of space removal. Such an observation will have an important medical implication: a much larger than expected radiation dose is needed for a tumor breakup enabling successful follow-up chemotherapy. Information on the TME’s hypoxia heterogeneity, as shown here with the numerical percolation model, may enable personalized precision radiation oncology therapy.     

大气消光特性与机载激光雷达眼睛安全关系的研究

依据美国ANSI标准，定量分析了气溶胶、卷云和沙尘的垂直消光特性对机载激光雷达激光脉冲眼睛安全最大阈值能量的影响；以地基激光雷达探测得到的合肥上空沙尘暴为例，定量给出了大气中各成分消光特性对飞机眼睛安全最低高度的影响；模拟计算了各种大气成分的消光特性对激光脉冲眼睛安全系数的影响随高度的变化规律。计算结果表明：沙尘层对激光脉冲眼睛安全最大阈值能量的影响幅度可达几十毫焦。该结果为我国第一台机载大气探测激光雷达激光脉冲能量设置提供了基本依据。