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Electrospun membranes are widely utilized to enhance the water vapor permeability and drug delivery performance of transdermal drug delivery patches. Due to the lack of adhesion property,however,most of them cannot closely contact with skin,which impedes the delivery of drugs to the skin,thus affecting the transdermal administration. C5 resin is used to endow poly(styrene isoprene styrene)(SIS)electrospun membranes with pressure-sensitive adhesion property. Investigation is performed on how to control the structure,adhesion properties and drug delivery performance of SIS/C5 electrospun membranes loaded with synthetic capsaicin via compositions,drugs and electrospinning conditions. The results demonstrate that the electrospun membrane with a SIS/C5 ratio of 2∶1 has excellent water vapor permeability(7. 17×10-3 g/(h·cm2)and adhesion properties(180(°)peel strength is 0. 2 kN/m,tack force is 0. 64 N/cm2 ,holding power is greater than 7 days). The synthetic capsaicin has good compatibility with the SIS/C5 electrospun membranes,in which no drug crystallizes and the drug loading is beneficial to improve the water vapor permeability. As the drug loading is 8%,the tack force is 0. 6~0. 8 N/cm2 ,the 180(°)peel strength is 0. 2~0. 3 kN/m,the holding power is greater than 7 days,and no residue is left during peeling tests. In vitro drug release indicates that the drug has a behavior of sustained release with a 24-hour cumulative release rate of greater than 50% for all SIS/ C5 electrospun membranes,meeting the requirements of transdermal drug delivery patches. © 2022, Science Press (China). All rights reserved. 相似文献
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简化了甘氨酸锌螯合物的合成,以甘氨酸和碱式碳酸锌为原料,按摩尔比为2:1的比例在水相中合成,90~95℃间反应6h,得到了产率为94.6%的水合甘氨酸锌螯合物.产品经纯化处理后用元素分析、红外光谱、紫外光谱、热重分析、粉末衍射等一系列方法进行表征.结果表明该螯舍物是带一个结晶水的分子化合物,摩尔电导率为20.1Scm^2·mol^-1,稳定常数为2.29×10^5.另外用凝胶色谱法测定了该螯合物的螯合率,得螯合率为100%±1%. 相似文献
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