The Attribute Based Hill Climber

In this paper we introduce the Attribute Based Hill Climber, a parameter-free algorithm that provides a concrete, stand-alone implementation of a little used technique from the Tabu Search literature known as regional aspiration. Results of applying the algorithm to two classical optimisation problems, the Travelling Salesman Problem and the Quadratic Assignment Problem, show it to be competitive with existing general purpose heuristics in these areas.     

Aspiration Based Simulated Annealing Algorithm

An aspiration based simulated annealing algorithm for continuousvariables has been proposed. The new algorithm is similar to the one givenby Dekkers and Aarts (1991) except that a kind of memory is introduced intothe procedure with a self-regulatory mechanism. The algorithm has beenapplied to a set of standard global optimization problems and a number ofmore difficult, complex, practical problems and its performance comparedwith that of the algorithm of Dekkers and Aarts (1991). The new algorithmappears to offer a useful alternative to some of the currently availablestochastic algorithms for global optimization.     

心肌细胞大变形黏弹性模型及在实验中的应用

在衡量单个细胞力学行为的研究中,越来越多地采用结合实验的数值模拟方法. 在连续介质力学框架下,发展了一种新的心肌细胞本构模型,并与微管吮吸实验结合,探讨了心肌细胞的力学特性. 本构模型是对普遍使用的仅能用于小变形分析的标准线性固体模型的一种扩展,它将超弹性性能引入到黏弹性模型中,用以描述细胞的大变形黏弹性效应. 基于改进的本构模型,对心肌细胞微管吮吸实验过程进行了有限元模拟,并将计算结果与实验结果以及经典理论解进行了对比. 结果显示发展的本构模型适合细胞大变形问题的有限元数值模拟.      

二级线性价格控制问题的满意解的求解思路及实例

本文就文献 [1]对线性二级价格控制问题 (BLP) 2 研究的结果及文献 [2 ]提出的问题进行了进一步的讨论。用反例指出文 [1]求出的极点最优解是错的 ,以及一般的 (BL P) 2 问题求出的最优解 ,可能是下层决策者根本无法接受的。因此 ,本文提出 (BLP) 2 的求下层目标最优解的边界搜索法及在此基础上用多目标的观点来求 (BLP) 2 的满意解的思路及实例     

ON ASPIRATION SOLUTIONS IN PREDICTING COALITION FORMATION IN COOPERATIVE GAMES

This paper consists of two parts. The first part introduces the strict aspiration as a new aspiration solution concept, which is proved to be existent for any cooperative game. The second part deals with the unsolved problem put forward by Bennett [1] by showing that there is at least one payoff which is balanced, partnered and equal gains aspiration. The proof is algebraic and constructive, thus providing an algorithm for finding such aspirations.     

Investigation on the viscoelasticity of synchronous hepatocellular carcinoma cells

Having made use of the micropipette aspiration technique, we here investigated the viscoelastic properties of hepatocellular carcinoma (HTC) cells from the view of cell cycle. The synchronous G₁ and S phase cells were achieved through thymine-2-desoryriboside and colchicine sequential blockage method and double thymine-2-desoryriboside blockage method, respectively. The synchronization results detected with flow cytometer showed that it could meet the requirements of the experiments nicely. Experimental results were analyzed with a standard linear solid viscoelastic model, in which an elastic element, K₁, is in parallel with a Maxwell element composed of another elastic element, K₂, in series with a viscous element, μ. The results indicated that high K₁, K₂ values and low μ value was the general characteristics of the cells; G₁ phase cells had higher K₁ values and low μ value than S phase cells, which endowed G₁ phase cells with higher elasticity and faster passive deformability than S phase cells. The results maybe also reflected the difference of cytoskeleton between G₁ and S phase cells, and suggested that G₁ phase cells were more suitable for surviving and metastasis in blood circulation than S phase cells.     

Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants

Droplet microfluidics can produce highly tailored microparticles whilst retaining monodispersity. However, these systems often require lengthy optimisation, commonly based on a trial-and-error approach, particularly when using bio-instructive, polymeric surfactants. Here, micropipette manipulation methods were used to optimise the concentration of bespoke polymeric surfactants to produce biodegradable (poly(d,l-lactic acid) (PDLLA)) microparticles with unique, bio-instructive surface chemistries. The effect of these three-dimensional surfactants on the interfacial tension of the system was analysed. It was determined that to provide adequate stabilisation, a low level (0.1% (w/v)) of poly(vinyl acetate-co-alcohol) (PVA) was required. Optimisation of the PVA concentration was informed by micropipette manipulation. As a result, successful, monodisperse particles were produced that maintained the desired bio-instructive surface chemistry.     

Adjusting learning motivation to promote cooperation

An evolutionary prisoner’s dilemma game with players adjusting their learning motivation is studied. At each time step, each player can adjust his/her learning motivation according to the difference between the current payoff and payoff aspiration. Greater payoff aspiration means stronger learning motivation, and vice versa. We find that the density of cooperation in a spatial prisoner’s dilemma game is enhanced when the learning motivation mechanism is considered. Meanwhile, we show that proper noise can not only induce the highest cooperation level but also can maintain the cooperation phenomenon even though there is more temptation to defect.     

智能平台下考虑主体心理行为的医疗服务供需匹配方法

基于智能平台的新兴医疗服务模式,可以有效缓解患者“看病难”问题。本文针对智能平台下医疗服务供需双方匹配的现实问题,提出了一种考虑主体心理行为的决策方法。在该方法中,考虑了医疗服务过程中主体的期望和犹豫不确定的心理特征。首先,比较双方主体在不同指标下的期望水平和评价信息之间的差距,计算得到双方差异度,并通过集结运算分别获得了双方满意度;在此基础上,分别以医疗服务供需双方的满意度最大为目标,构建了智能平台下医疗服务供需匹配的多目标优化模型,通过模型求解可得到最优匹配结果;最后,通过算例分析说明了本文提出方法的可行性和有效性。     

Fine Needle Aspiration: A Novel Application in Laryngology

Fine needle aspiration (FNA) has had an early start in medicine and has been heavily used in the United States since the 1980s. It is regarded as a highly effective means to sample mass lesions, serving as the first diagnostic procedure in many instances. FNA is safe, less invasive than biopsy, and reduces the risk of scar formation. Its main limitations can be overcome through effective training and practiced technique. In laryngology, the development of new and diversified therapeutic and diagnostic strategies depends on the development of equally appropriate diagnostic tools. FNA has the potential to be a relatively easy procedure that can be performed under local anesthesia, increasing the otolaryngologist's armamentarium. Combining the FNA procedure with technology now available, secondary to advances in genomic science, rather than cytology and H&E stains, provides the means of obtaining clinically useful information about benign and malignant disease for clinicians and researchers. This paper provides a review of the traditional FNA procedure. It offers an introduction to the future applicability of FNA to office-based laryngology. Lastly, this paper familiarizes the reader with the genomic principles being used for this procedure.