仿生自组装纳米复合薄膜的制备与摩擦行为研究

利用分子自组装法在玻璃表面制备未聚合与聚合（丙烯酸十二醇酯／二氧化硅）有机－无机有序交替的层次纳米复合薄膜,并对其摩擦学行为进行了探讨。结果表明：未聚合或聚合薄膜的结构类似于海洋贝类的贝壳结构,与钢球对摩时都有较好的减摩性,摩擦系仅为0．1;而聚合薄膜的抗磨性能大幅提高,其失效循环次数为未聚合薄膜的6倍。     

Racemic and enantioselective total synthesis of heliespirones A&C

An account of the total synthesis of(±)-,(+)-heliespirone A and(±)-,(-)-heliespirone C is presented.In the first-generation total synthesis,we found rac-24a could be easily transformed to rac-heliespirones A&C in a biomimic way.Taking the disappointing diastereoselectivity of prenylation from 3 to 4,the nonselective dihydroxylation from 4 to 5 and the lenthy route in strategy A into account,we designed a different synthetic plan targeting a highly enantioselective,concise and protective-group free synthesis...     

孔蛋白-磷脂仿生膜的葡萄糖氧化酶电化学

采用孔蛋白（MspA）和双肉豆蔻磷脂酰胆碱（DMPC）在玻碳（GC）基底表面成功构建有仿生特性的纳米通道膜,同时将葡萄糖氧化酶（GOD）修饰于膜上. 使用循环伏安法研究GOD/MspA-DMPC/GC电极的GOD直接电化学过程以及其对氧气和葡萄糖的响应. 研究发现,MspA与DMPC形成的仿生纳米通道膜内,GOD在接近生物体系FAD/FADH标准电位处实现了自身两质子、两电子表面控制的电化学反应. MspA与DMPC的仿生纳米通道膜体系为GOD提供了理想活性环境.     

多功能超润湿材料的设计制备与应用

仿生超润湿材料是指类似自然界中生命体具有的特殊浸润界面性质的一类材料。近20年来,研究人员通过模仿自然,揭示了一系列超润湿界面材料的构建机理,设计制备了多种仿生超润湿材料,并将这些具有特殊表面浸润性能的材料拓展应用到了国防、军工、航空航天、建筑、农业、医疗、海洋防污等众多领域。本文首先介绍表面润湿现象的基础理论,接着从仿生的角度出发,介绍了以仿荷叶、鱼鳞、沙漠甲虫、猪笼草为代表的几种拥有不同表面浸润性能的材料,并总结了这几种材料的仿生设计原理、结构与性能的关系以及所面临的问题。综述了近年来仿生超润湿材料在防污抗菌、防雾防霜防覆冰、油水分离等方面的应用进展,最后展望了仿生超润湿材料的发展方向。     

Electrochemical Acetylcholine Chloride Biosensor Using an Acetylcholine Esterase Biomimic

Abstract

Pure enzymes are costly and highly sensitive to change in pH, temperature, ionic strength etc. Hence biomimetic or synthetic enzymes could be useful alternatives to such natural proteins. Although the selectivity of a biomimic is somewhat less than that of enzyme, it can be used as a detector element in inexpensive but stable biosensors. An organic compound, 4-[(1E)-ethanehydrazonoyl]benzoic acid, has been designed and synthesized as biomimic for the enzyme acetylcholine esterase. An acetylcholine chloride two-electrode screen-printed sensor was first developed using the immobilized enzyme acetylcholine esterase. The performance of the mimic in the hydrolysis of acetylcholine chloride was then tested with the same transducer by immobilizing the biomimic in place of the enzyme. The response of the sensor constructed using the mimic was comparable to that of the pure acetylcholine esterase enzyme electrode.     

Synthesis of Analogs of Phosphoamino Acids and their Biomimic Reactions

Previ0uslyitwasf0undthatphosph0amin0acidscouldstimulatemanyinterestingbioorganicreacti0nsI-3.In0rderfurthert0confirmthesignificanceofph0sphorusinbiochemistry,tw0m0delcomp0unds,anal0gue0fphosphorylaminoacidsc0ntainingP-Cbondandphosphorylglucoaminoacids,weresynthesized.Theirreacti0nswithalcoholandamin0acidwerealsoinvestigatedbyNMRandMSmeth0ds.Theresultsindicatedthatthereactioncharacteristicsofphosphorylbio1ogicalsmallmoleculesweredependentonthe'configuration,functiongroupsandpositions.(O,O-b…     

Differentiation Effect of Pentacoordinate Phosphorus on Carbohydrate Reaction

Glycosylphosphatesareofconsiderableinterestasintermediatesforthesynthesisofnucleotideandoligosaccharidesinglycoproteinsandglycolipids'i.However.thereisnosuchreporttogivewhyonlypentoseD-riboseisusedasthecentralblockinnucleotideandinATP,butnotthehexoseD-glucose,despiteofD-glucosepossessingveryrichsource.Therefore,itisnecessarytoinvestigatethepossiblereactionmechanismofcarbohydratephosphorylation.Thepentacoordinatephosphorusintermediatewasproposedtoparticipateinbiologicalprocess'-'.Inordertoob…