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Philip Steib Prof. Dr. Bernhard Breit 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(14):3532-3535
A short and efficient synthesis of the C2-symmetric antibiotic (−)-vermiculine by utilizing an enantioselective catalytic one-step dimerization methodology as key-step to construct the core structure is reported. The late-stage modifications feature a double metathesis homologation followed by a double Wacker-type oxidation. These key-steps allowed the synthesis of vermiculine in only seven steps, starting from commercially available building blocks. 相似文献
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