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Synthesis and reactivity of 3-(trichlorogermyl)propanoic acid and 3-(triphenylgermyl) propanoic acid
3-(Trichlorogermyl)propanoic acid (la) reacts with phenylmagnesium bromide in malar ratio 1:4 to give 3-(triphenylgermyl)propanoic acid (2a).In the compounds la and 2a theβ-carboxylic functional group shows some unusual properties when they react with excess of phenylmagnesium bromide.The compound la reacts with phenylmagnesium bromide in molar ratio 1:5 to give phenyl 2-(triphenylgermyl)ethylketone (3a) and in molar ratio 1:6 to give l,l-diphenyl-3-(triphenylgermyl)propanol (4a).The compound 2a reacts with phenylmagnesium bromide in molar ratio 1:2 to give 3a and in molar ratio 1:3 to give 4a also.Dehydration of the compound 4a with dilute hydrochloric acid seems especially easy.Moreover,the compound la reacted with phenylmagnsium bromide in molar ratio 1:6,then the mixture was treated with dilute hydrochloric acid to give 1,1-diphenyl-3-(triphenylgermyl)-1-propene (5a) in one pot reaction.Alkyl Ge-C bond in the compound 5a can be cleaved selectively by lithium aluminium hydride ( LiAlH4) in good yiel 相似文献
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A series of new N‐benzoyl‐N‐tert‐butyl‐N′‐(β‐triphenylgermyl)propionylhydrazines were synthesized by the condensation reaction of β‐triphenylgermyl propanoic acid with N‐benzoyl‐N‐tert‐butylhydrazines in good yields by using N,N′‐dicyclohexylcorbodiimide as dehydrating agent. These title compounds were evaluated for molting hormone mimicking activity. The results of bioassay showed that the compounds exhibit moderate larvicidal activity, and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We found that the title compounds possess potential anticancer activities in vitro. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
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我们合成了有机锗化合物的一类重要中间体β-三苯锗基丙酸和β-三苯锗基丁酸 ,测量了该化合物的拉曼光谱和红外光谱 ,经光谱分析 ,指认了主要波数所对应的分子振动。在这两种化合物的拉曼光谱中 ,30 50 cm- 1( m)、1 0 2 5cm- 1( m)和 61 8cm- 1( m)分属于 Ph- H的伸缩振动、面内弯曲振动和面外扭曲振动。饱和 Ge- C键的振动分别在 594cm- 1和 587cm- 1,同时指出了 Ph- Ge的几种振动所对应的振动频率。在红外光谱中 ,C=O的振动出现在 1 70 9cm- 1( s)和 1 70 5cm- 1( s) ,与饱和碳相连接的 Ge- C振动出现在 61 7cm- 1( w)和 61 7cm- 1( w)。 相似文献
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