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1.
Electrochemical oxidation of thio/carbohydrazide and their hydrazone derivatives Benzaldehyde thiocarbohydrazone [BTCH] diacetylene
thiocarbohydrazone [DATCH] have been studied in Brit-ton Robinson buffer in aqueous and nonaqueous media at a glassy carbon
electrode. The effects of pH, sweep rate, concentration, temperature and surfactants have been studied. The complex bis (carbo/thiocabohydrazide) Zn(II) chloride was also subjected to voltammetric analysis in order to understand the reactivity
both in free and metal bound states. The reaction conditions were optimized for the determination of above compounds in micrograms
quantities by differential pulse voltammetry, analytical utility of this investigation is also highlighted. 相似文献
2.
G. Mekuskiene M. M. Burbuliene V. Jakubkiene E. Udrenaite P. Gaidelis P. Vainilavicius 《Chemistry of Heterocyclic Compounds》2003,39(10):1364-1368
5-(4,6-Diphenyl-2-pyrimidinyl)-1,3,4-oxadiazole-2-thione reacted with haloalkanes or their derivatives containing side chain oxo group to give S-alkylated compounds. Aminomethylation and acylation of the thione yielded N(3)-derivatives. Treatment of the title compound with hydrazine hydrate in butanol resulted in 4-amino-5-(4,6-diphenyl-2-pyrimidinyl)-1,2,4-triazole-3-thione via a recyclization reaction. Reaction of the title compound with hydrazine hydrate or phenylhydrazine in dioxane led to formation of the corresponding thiocarbohydrazides. The latter in the presence of a base were cyclized to 4-amino-1,2,4-triazole-3-thiones. 相似文献
3.
1,5-二(2-羟基苯亚甲基)-二氨基硫脲与银配合物的合成、表征及抗癌活性研究 总被引:9,自引:0,他引:9
近年来,由于缩氨基硫脲类过渡金属配合物具有较高的抗癌、抗菌活性,受到化学界和药学界研究人员的广泛重视。实验证明不同缩氨基硫脲与不同过渡金属形成的配合物其抗癌活性不同。1,5-二(2-羟基苯亚甲基)-二氨基硫脲是一种水杨醛缩氨基硫脲类衍生物,而有关其银配合物的合成及抗肿瘤方面的研究目前尚未见报道。鉴于此,我们在以前工作的基础上合成了标题化合物,通过元素分析、红外光谱、紫外光谱、核磁共振氢谱、摩尔电导和溶解性等测试,对配合物进行了表征。同时测定了配体和配合物的抗肿瘤活性,旨在为开发新的抗肿瘤药物提供理论依据。 相似文献
4.
Sreenu Pavurala Krishnaiah Vaarla Rajeshkumar Kesharwani Lieve Naesens Sandra Liekens 《合成通讯》2018,48(12):1494-1503
A series of novel 3,3′-(3,3′-(dihydroxy/hydroxyethane-1,2-diyl)bis(7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-6,3-diyl))bis(2H-chromen-2-ones) were prepared by the condensation of thiocarbohydrazide with tartaric acid or malic acid followed by various 3-(2-bromoacetyl)-2H-chromen-2-ones in two steps with good yields. All the synthesized compounds were characterized by analytical and spectral (IR, 1H NMR, 13C NMR, and mass) data. These synthesized bis(triazolothiadiazinyl coumarin) compounds were evaluated for broad spectrum of antiviral activity. Among all the tested compounds, compound 5f exhibited antiviral activity against H1N1 virus. The molecular docking studies of these compounds against H1N1 neuraminidase enzyme were performed. The binding affinity and binding values were compared with standard drugs. 相似文献
5.
6.
A stable nickel‐decorated SBA‐15 nanocomposite (Ni/TCH@SBA‐15) was synthesized through surface modification of silica nanoparticles with 3‐chloropropyltriethoxysilane (CPTES) and thiocarbohydrazide (TCH) followed by metal–ligand coordination with Ni (II). The structure of this organometallic nanocomposite was characterized by Fourier transform‐infrared, field emission‐scanning electron microscopy, EDAX, transmission electron microscopy, atomic absorption spectroscopy and N2 adsorption–desorption (Brunauer–Emmett–Teller) techniques. The catalytic performance of Ni/TCH@SBA‐15 (NNTS‐15) was determined for the synthesis of 2‐aryl‐substituted benzimidazoles and 2,3‐dihydroperimidines. The excellent yields within shorter reaction times, simplicity of catalytic methods, non‐toxicity and clean reactions, mild reaction conditions and easy work‐up procedure are the important merits of these synthetic protocols. Moreover, the Ni (II) bonded to the SBA‐15 surface was stable under the catalytic reaction conditions resulting in its efficient recycling and reuse. 相似文献
7.
《Journal of Coordination Chemistry》2012,65(20):3364-3380
AbstractFive novel ONS donor Schiff base ligands were synthesized by the reaction of 2-hydroxybenzophenone (L1), 2-hydroxy-4-methoxybenzophenone (L2), 2-hydroxy-4-octyloxybenzophenone (L3), 2-hydroxy-4-methoxy-4′-methylbenzophenone (L4), and 2-hydroxy-4-allyloxybenzophenone (L5) with thiocarbohydrazide. Neutral solvate dioxomolybdenum(VI) complexes with the general formula [MoO2L(ROH)], [C1–C5] (L?=?L1, L2, L3, L4, L5 and R?=?CH3, C2H5, or C4H9), were prepared from these Schiff bases. Characterization of all compounds was carried out by means of elemental analysis, conductivity measurements, 1H-NMR, FT-IR, UV-Vis spectroscopy and mass spectrometry (for L1, C2, and C4) techniques. The crystal structures of ligand (L5) and complex (C1) were determined by single-crystal X-ray crystallography. Spectroscopic data and X-ray diffraction studies confirmed that the ligand is coordinated to the cis-MoO22+ core through ONS, while the sixth coordination site is occupied by solvent (ROH). The ligands and complexes were tested for in vitro antioxidant capacities. The TEAC coefficients of the ligands and complexes were found higher than reference compound. DPPH radical scavenging activities of these compounds were also investigated. 相似文献
8.
Venkata Sreenivasa Rao Chunduru 《合成通讯》2013,43(10):1454-1460
An expeditious, one-pot reaction has been described for the preparation of 1,3,4-thiadiazin-5-yl-chromen-2-one derivatives. These compounds were synthesized by the reaction of 3-(2-bromoacetyl)coumarin with thiocarbohydrazide and various carbonyl compounds. The newly synthesized compounds were characterized by infrared, 1H NMR, and mass spectra. 相似文献
9.
Abdullah G. M. Al-Sehemi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(8):1991-2003
The starting material 1,2,4-triazole derivative ( 3 ) was used to synthesize some novel condensed triazoles. Thus, treatment of compound ( 3 ) with phenyl isocyanate in refluxing pyridine furnished the novel [1,2,4]triazolo[4,3-b][1,2,4]triazole derivative ( 5 ). Also, cyclization of compound ( 3 ) with phenyl isothiocyanate afforded the [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivative ( 7 ). Hydrazone derivative ( 9d ) was allowed to react with some halogenated reagents such as chloroacetone, ethyl chloroacetate, and chloroacetonitrile to furnish thiazole derivatives ( 12 ), ( 13 ), and ( 15 ), respectively. In a similar manner, bishydrazone ( 17 ) was used to prepare the novel bisthiazoles ( 18 ) and ( 19 ). Some of the synthesized compounds were evaluated for their antibacterial activity. 相似文献
10.
A one-pot, three-component protocol for the synthesis of novel five-membered thiazole ring bonded to two hydrazone motifs is described. The acid-catalyzed reaction of one equivalent of thiocarbohydrazide, two equivalents of aromatic aldehydes, and one equivalent of phenacyl bromides afforded the five-membered thiazole ring. The reactions proceed with novel chemoselectivity. Similar reported protocols have always afforded 1,3,4-thiadiazines. 相似文献