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Ibrahim M. A. Awad Abdu E. Abdel-rahman Etify A. Bakhite 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):63-71
Abstract 3-Aryloxymethyl-4-phenyl-5-mercapto-s-triazoles (Ia-c) have been synthesized and reacted with N-chloroacetyl derivatives of aromatic and/or heterocyclic amines to yield 5-(N-aryl/heterocyclyl)-carboxamidomethyl thio-s-triazole derivatives 2a-o and 3a-o respectively. Reaction of Ia-u with ethyl chloroacetate gave the corresponding esters 4a-c which were reacted with hydrazine hydrate to give hydrazides 5a-c. Condensation of 5a-c with aromatic aldehydes gave Schiff s bases 6a-u with on cycloaddition reaction with thioglycolic acid yielded 4-thiazolidinones 7a-g. Some of these compounds were screened in vitro for their antibacterial activities. 相似文献
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