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1.
Wei Zhang Lin Deng Guangchao Wang Xianrong Guo Qiujin Li Jianfei Zhang Niveen M. Khashab 《Particle & Particle Systems Characterization》2014,31(9):985-993
Multifunctional magnetic microcapsules (MMCs) for the combined cancer cells hyperthermia and chemotherapy in addition to MR imaging are successfully developed. A classical layer‐by‐layer technique of oppositely charged polyelectrolytes (poly(allylamine hydrochloride) (PAH) and poly(4‐styrene sulfonate sodium) (PSS)) is used as it affords great controllability over the preparation together with enhanced loading of the chemotherapeutic drug (doxorubicin, DOX) in the microcapsules. Superparamagnetic iron oxide (SPIOs) nanoparticles are layered in the system to afford MMC1 (one SPIOs layer) and MMC2 (two SPIOs layers). Most interestingly, MMC1 and MMC2 show efficient hyperthermia cell death and controlled DOX release although their magnetic saturation value falls below 2.5 emu g?1, which is lower than the 7–22 emu g?1 reported to be the minimum value needed for biomedical applications. Moreover, MMCs are pH responsive where a pH 5.5 (often reported for cancer cells) combined with hyperthermia increases DOX release predictably. Both systems prove viable when used as T2 contrast agents for MR imaging in HeLa cells with high biocompatibility. Thus, MMCs hold a great promise to be used commercially as a theranostic platform as they are controllably prepared, reproducibly enhanced, and serve as drug delivery, hyperthermia, and MRI contrast agents at the same time. 相似文献
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Dr. Qaisar Nadeem Dr. Federica Battistin Dr. Olivier Blacque Prof. Dr. Roger Alberto 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(5):e202103566
Bis-arene sandwich complexes are generally prepared by the Fischer-Hafner reaction, which conditions are incompatible with most O- and N- functional groups. We report a new way for the synthesis of sandwich type complexes [Re(η6-arene)2]+ and [Re(η6-arene)(η6-benzene)]+ from [Re(η6-napht)2]+ and [Re(η6-napht)(η6-benzene)]+, with functionalized arenes and pharmaceuticals. N-methylpyrrolidine (NMP) facilitates the substitution of naphthalene with the incoming arene. A series of fully characterized rhenium sandwich complexes with simple arenes, such as aniline, as well as with active compounds like lidocaine and melatonin are presented. With these rhenium compounds in hand, the radioactive sandwich complexes [99mTc(η6-pharm)2]+ (pharm=pharmaceutical) can be unambiguously confirmed. The direct labelling of pharmaceuticals with 99mTc through η6-coordination to phenyl rings and the confirmation of the structures with the rhenium homologues opens a path into molecular theranostics. 相似文献
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Theranostics is a precision medicine which integrates diagnostic nuclear medicine and radionuclide therapy for various cancers throughout body using suitable tracers and treatment that target specific biological pathways or receptors. This review covers traditional theranostics for thyroid cancer and pheochromocytoma with radioiodine compounds. In addition, recent theranostics of radioimmunotherapy for non-Hodgkin lymphoma, and treatment of bone metastasis using bone seeking radiopharmaceuticals are described. Furthermore, new radiopharmaceuticals for prostatic cancer and pancreatic cancer have been added. Of particular, F-18 Fluoro-2-Deoxyglucose (FDG) Positron Emission Tomography (PET) is often used for treatment monitoring and estimating patient outcome. A recent clinical study highlighted the ability of alpha-radiotherapy with high linear energy transfer (LET) to overcome treatment resistance to beta--particle therapy. Theranostics will become an ever-increasing part of clinical nuclear medicine. 相似文献
4.
贵金属纳米材料在纳米尺度具有独特的光学、 电学性质及优异的催化性能, 是一类重要的功能纳米材料. 基于贵金属材料的纳米酶研究是贵金属纳米材料在生物医学领域的一个前沿研究方向. 贵金属基纳米酶具有特殊的光学性质、 较好的化学稳定性、 可调控的类酶活性及良好的生物相容性, 是目前纳米生物医学领域的热点研究材料. 本文总结了贵金属基纳米酶的活性种类、 活性机理、 活性调控以及在生物医学等领域的潜在应用. 相似文献
5.
Thomas D. MacDonald Dr. Tracy W. Liu Prof. Gang Zheng 《Angewandte Chemie (International ed. in English)》2014,53(27):6956-6959
Photothermal therapy makes use of photothermal sensitizers and laser light to thermally ablate diseased tissues. Porphysome nanoparticles offer a nontoxic alternative to inorganic nanocrystals for the efficient conversion of light into heat. Mn3+ ions were incorporated directly into the building blocks of our porphysome nanoparticles, thus imparting MRI sensitivity while simultaneously improving photostability and maintaining high photothermal efficiency. Mn porphysomes are as photothermally effective as free‐base porphysomes and can rival gadolinium diethylenetriaminepentaacetate (Gd‐DTPA) for MRI contrast generation. Their MRI contrast generation, photothermal efficiency, and photostability are unprecedented for an all‐organic nanoparticle composed of a single functional component. 相似文献
6.
Shuang Liu Xueting Pan Huiyu Liu 《Angewandte Chemie (International ed. in English)》2020,59(15):5890-5900
Two‐dimensional (2D) nanomaterials are currently explored as novel photothermal agents because of their ultrathin structure, high specific surface area, and unique optoelectronic properties. In addition to single photothermal therapy (PTT), 2D nanomaterials have demonstrated significant potential in PTT‐based synergistic therapies. In this Minireview, we summarize the recent progress in 2D nanomaterials for enhanced photothermal cancer therapy over the last five years. Their unique optical properties, typical synthesis methods, and surface modification are also covered. Emphasis is placed on their PTT and PTT‐synergized chemotherapy, photodynamic therapy, and immunotherapy. The major challenges of 2D photothermal agents are addressed and the promising prospects are also presented. 相似文献
7.
Jianhua Zou Jianwei Zhu Zhen Yang Ling Li Wenpei Fan Liangcan He Wei Tang Liming Deng Jing Mu Yuanyuan Ma Yaya Cheng Wei Huang Xiaochen Dong Xiaoyuan Chen 《Angewandte Chemie (International ed. in English)》2020,59(23):8833-8838
Continuous irradiation during photodynamic therapy (PDT) inevitably induces tumor hypoxia, thereby weakening the PDT effect. In PDT‐induced hypoxia, providing singlet oxygen from stored chemical energy may enhance the cell‐killing effect and boost the therapeutic effect. Herein, we present a phototheranostic (DPPTPE@PEG‐Py NPs) prepared by using a 2‐pyridone‐based diblock polymer (PEG‐Py) to encapsulate a semiconducting, heavy‐atom‐free pyrrolopyrrolidone‐tetraphenylethylene (DPPTPE) with high singlet‐oxygen‐generation ability both in dichloromethane and water. The PEG‐Py can trap the 1O2 generated from DPPTPE under laser irradiation and form a stable intermediate of endoperoxide, which can then release 1O2 in the dark, hypoxic tumor microenvironment. Furthermore, fluorescence‐imaging‐guided phototherapy demonstrates that this phototheranostic could completely inhibit tumor growth with the help of laser irradiation. 相似文献
8.
《Particuology》2022
2D nanomaterials are widely investigated for biomedical applications, attributed to their large specific surface area, high therapeutic loading capacity, and unique optical, thermal, and/or electronic characteristics. Lattice defects affect the theranostic performance of 2D nanomaterials significantly by altering their electronic properties and chemical binding. Recent investigations have shown that defect-rich 2D nanomaterials are capable of enhancing tumor treatment through efficient drug delivery, photothermal and photodynamic therapies (PTT and PDT), and improving diagnostics via computed tomography (CT), photoacoustic and magnetic resonance imaging. This review summarizes recent progresses, including synthesis, characterization approach, and applications of defect-engineered 2D nanomaterials that are potentially useful in cancer treatment. The expert opinions are also proposed as the conclusion. 相似文献
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A p‐Hydroxyphenacyl–Benzothiazole–Chlorambucil Conjugate as a Real‐Time‐Monitoring Drug‐Delivery System Assisted by Excited‐State Intramolecular Proton Transfer
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Shrabani Barman Sourav K. Mukhopadhyay Sandipan Biswas Surajit Nandi Moumita Gangopadhyay Satyahari Dey Anakuthil Anoop N. D. Pradeep Singh 《Angewandte Chemie (International ed. in English)》2016,55(13):4194-4198
Among the well‐known phototriggers, the p‐hydroxyphenacyl (pHP) group has consistently enabled the very fast, efficient, and high‐conversion release of active molecules. Despite this unique behavior, the pHP group has been ignored as a delivery agent, particularly in the area of theranostics, because of two major limitations: Its excitation wavelength is below 400 nm, and it is nonfluorescent. We have overcome these limitations by incorporating a 2‐(2′‐hydroxyphenyl)benzothiazole (HBT) appendage capable of rapid excited‐state intramolecular proton transfer (ESIPT). The ESIPT effect also provided two unique advantages: It assisted the deprotonation of the pHP group for faster release, and it was accompanied by a distinct fluorescence color change upon photorelease. In vitro studies showed that the p‐hydroxyphenacyl–benzothiazole–chlorambucil conjugate presents excellent properties, such as real‐time monitoring, photoregulated drug delivery, and biocompatibility. 相似文献