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Mura P. Maestrelli F. Cirri M. Furlanetto S. Pinzauti S. 《Journal of Thermal Analysis and Calorimetry》2003,73(2):635-646
The interactions of trimethoprim, sulphadiazine and sulphamethoxazole with natural (a- b-, g- ) and amorphous (RAMEB) or crystalline
(DIMEB) methylated b-cyclodextrins were investigated both in aqueous solution (using phase-solubility analysis) and in the
solid state (using DSC supported by X-ray analysis). In particular, DSC studies enabled determination of the relative degree
of crystallinity of each drug in its physical and ground mixtures with the different cyclodextrins on the basis of the variation
of its heat of fusion in comparison with that of the pure drug. In all cases, the host cavity size was a prevalent factor
for the inclusion complexation in liquid state. On the contrary, it had a negligible effect on solid-state interactions in
terms of drug amorphization. DIMEB and RAMEB exhibited similar performances in aqueous solution, showing that the presence
of methyl-groups improved the complexing and solubilizing properties of b-cyclodextrin. However, DSC studies revealed that
RAMEB was clearly more active in performing solid-state interactions, i.e. drug amorphization, and as stabilizing agent for
the amorphous state brought forth.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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A tentative assignment of the vibrational modes of sulphadiazine is made, based on the infrared and Raman data. In addition, dirhodium tetracarboxylates and their adducts with sulphadiazine are investigated by Raman spectroscopy, with emphasis in the identify the metal-metal and metalligand stretching modes. 相似文献
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《Analytical letters》2012,45(12):2215-2231
Abstract A high performance liquid chromatographic (HPLC) method for the determination of sulphadiazine and trimethoprim in medicated fish feedstock is described. It is based on the extraction of the drugs into methanol followed by separation on a μ-Bondapak column using an aqueous acetonitrile mobile phase of pH 3.0. The method was validated by determining intra- and inter-assay precision and the coefficient of variation was found to be less than 8% for both drugs. Callbration curves were linear over the range 160–4000 pg drug per g of feedstock and the method was applied to the determination of a commercial feedstock formulation. 相似文献
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本文采用岛津CS-930型薄层扫描仪,以紫外反射吸收方式灵敏快速地测定了增效联磺片中磺胺嘧啶的含量。λs=270nm,散射参数Sx=3,薄层厚度0.3mm;展开剂为氯仿:乙醇:庚烷(1:1:1),平均回收率为98.01%,检出限为0.05μg。 相似文献
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