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Phospholipid lung surfactant and nanoparticle surface toxicity: Lessons from diesel soots and silicate dusts 总被引:3,自引:0,他引:3
William E. Wallace Michael J. Keane David K. Murray William P. Chisholm Andrew D. Maynard Tong-man Ong 《Journal of nanoparticle research》2007,9(1):23-38
Because of their small size, the specific surface areas of nanoparticulate materials (NP), described as particles having at
least one dimension smaller than 100 nm, can be large compared with micrometer-sized respirable particles. This high specific
surface area or nanostructural surface properties may affect NP toxicity in comparison with micrometer-sized respirable particles
of the same overall composition. Respirable particles depositing on the deep lung surfaces of the respiratory bronchioles
or alveoli will contact pulmonary surfactants in the surface hypophase. Diesel exhaust ultrafine particles and respirable
silicate micrometer-sized insoluble particles can adsorb components of that surfactant onto the particle surfaces, conditioning
the particles surfaces and affecting their in vitro expression of cytotoxicity or genotoxicity. Those effects can be particle surface composition-specific. Effects of particle
surface conditioning by a primary component of phospholipid pulmonary surfactant, diacyl phosphatidyl choline, are reviewed
for in vitro expression of genotoxicity by diesel exhaust particles and of cytotoxicity by respirable quartz and aluminosilicate kaolin
clay particles. Those effects suggest methods and cautions for assaying and interpreting NP properties and biological activities. 相似文献
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We present a model for the silicosis disease mechanism following the original proposal by Tran et al. (1995), as modified recently by da Costa et al. (2020). The model consists in an infinite ordinary differential equation system of coagulation–fragmentation–death type. Results of existence, uniqueness, continuous dependence on the initial data and differentiability of solutions are proved for the initial value problem. 相似文献
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J. L. Tourmann R. Kaufmann 《International journal of environmental analytical chemistry》2013,93(1-4):215-227
Abstract The lack of clearcut correlations between toxicity of most samples of particulate airborne matter and conventional physico-chemical data may widely be ascribed to the heterogeneity of such materials. A “single particle approach” is necessary to take account of heterogeneity down to the level of individual particles. The present study illustrates the analytical capabilities of LAser Microprobe Mass Spectrometry (LAMMS) for characterizing individual particles. The concept of “exogen” and “endogen” mixtures are presented and applied to the mineral matter of coal mine dusts. Toxicological relevance of the results are discussed as compared to conventional mineralogical data. This approach sheds new light on the specific harmfulness of coal mine dusts. 相似文献
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测定了陶工I期尘肺患者的头发中Zn、Cu、Se、Ni、Fe、Mn、Mg7种金属元素,用陶工可疑患者作对照,建立Fisher判别方程,对陶工尘肺进行判别。自身回代正确率94.44%,前瞻性回代达83.33%,各其流行病学指标计算均属良好。 相似文献
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J. Miñones M. I. Sandez Macho E. Iribarnegaray P. Sanz Pedrero 《Colloid and polymer science》1981,259(4):450-461
Summary The action of polymerized silicic acid on lecithin and cephalin monolayers brings about changes in its physical state, molecular area, and pressure of collapse. These changes are more notable in the case of lecithins, varying not only with the substrate pH, but also with the length of the hydrocarbon chains of the fatty acids that esterify glycerol in the molecules of these substances. The different actions observed between silicic acid and the lecithin and cephalin monolayers are explained with the help of different models.With 11 figures 相似文献
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