Triazoles and Fused Triazoles II: Synthesis of Certain Substituted s-Triazoles,s-Triazolo[3,4-b]-1,3,4-Thiadiazoles and s-Triazolo [3,4-b]-1, 3,4-Thiadiazines

The synthesis of a certain series of s-triazoles and fused s-triazoles namely: 3-(3,4-dimethoxyphenyl)-4-arylideneamino-5-mercapto-s-triazoles 3.8 , 3-(3,4-dimethoxyphenyl)-6-substituted-s-triazolo[3,4-b]-1,3,4-thiadiazoles 11-17 , 3-(3,4-dimethoxyphenyl)-6-substituted thio-s-triazolo[3,4-b]-1,3,4-thiadiazoles 19, 20 and 3-(3,4-dimethoxyphenyl)-6-substituted-7H-s-triazolo[3,4-b]-1,3,4-thiadiazines 21, 22 , is described.     

Synthesis of Certain S-Triazole and s-Triazolo[3,4-B] 1,3,4-Thiadiazole Derivatives of Expected Pharmacological Activity

Reaction of the newly prepared 3-(2-thienyl)-4-amino-s-triazole-5-thione (I) with different alkyl kalides and aromatic aldehydes afforded the corresponding thioethers and arylidene derivatives (II and III), respectively. Attempt ring closure of (I) with acetic anhydride produced the unexpected triacetyl derivative (IV). The synthesis of certain 3-(2-thienyl)-6-substituted-s-triazolo[3,4-b] 1,3,4-thiadiazoles (V and VII) was described. IR, NMR and mass spectral analyses of the prepared compounds were discussed.