肾性骨病与微量元素铝相关性观察

观察了32例慢性肾功能衰竭(CRF)患者血铝含量,平均为12668±06358,明显高于正常人血铝07286±00826,P<001;血铝与血钙水平呈负相关r=-06235,P<005;肾性骨病(ROD)患者血铝明显高于非骨病患者(P<005)。提出CRF患者有明显铝蓄积,并且与ROD有相关性。对CRF患者应注意血铝的监测,以便进行针对性预防和治疗。     

On an integrable deformed affinsphären equation. A reciprocal gasdynamic connection

The integrable affinsphären equation originally arose in a geometric context but has an interesting gasdynamic connection. Here, an integrable deformed version of the affinsphären equation is derived in a novel manner via the action of reciprocal transformations on a related anisentropic gasdynamics system. A linear representation for the deformed affinsphären equation is constructed by means of the reciprocal transformations. The latter are then employed to derive a class of exact solutions in parametric form.     

Stacking‐Layer‐Number Dependence of Water Adsorption in 3D Ordered Close‐Packed g‐C3N4 Nanosphere Arrays for Photocatalytic Hydrogen Evolution

Water adsorption capacity is a key factor to influence the photocatalytic H₂ evolution activity of polymeric g‐C₃N₄ . Herein, we report the synthesis of 3D ordered close‐packed g‐C₃N₄ nanosphere arrays (CNAs) that significantly enhance the water adsorption capacity. Through precisely controlling the average stacking‐layer number (ASLN) of the nanospheres in CNAs, we reveal an interesting stacking‐layer‐number dependence of water adsorption in the newly designed CNAs for accelerating the H₂ evolution reaction, which can be attributed to the differences in adsorption surface areas and adsorption sites endowed by the point‐defect cavities in sample CNAs.     

Isolation of the intermetallic compounds Al2Cu, Al12Mg17 Al3Fe, Al9Co2 and Al3Ni in binary aluminium alloys by application of an organic solvent

Summary For the isolation of the intermetallic compounds Al₂Cu, Al₁₂Mg₁₇, Al₃Fe, Al₉Co₂ and Al₃Ni in their binary alloys a new method is proposed: Sample alloy particles are placed in a flask with a methanolic solution of benzoic acid (20% wt.), oxine (5% wt.), chloroform (20% vol.) and sodium hydroxide (0.02% wt.). After sufficient time of agitation, the intermetallic compounds remain quantitatively in the solution.

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Isolierung der intermetallischen Verbindungen Al₂Cu, Al₁₂Mg₁₇, Al₃Fe, Al₉Co₂ und Al₃Ni aus binären Aluminiumlegierungen mit Hilfe eines organischen Lösungsmittels

Zusammenfassung Zur Isolierung der intermetallischen Verbindungen aus den entsprechenden binären Legierungen wird die Probe mehrere Stunden bis Tage unter Rühren mit einer methanolischen Lösung von Benzoesäure (20%), Oxin (5%), Chloroform (20%) und Natriumhydroxid (0,02%) behandelt. Hierbei wird die Matrix aufgelöst und die intermetallischen Verbindungen bleiben zurück.

     

Structure-Based Design of a Macrocyclic PROTAC

Constraining a molecule in its bioactive conformation via macrocyclization represents an attractive strategy to rationally design functional chemical probes. While this approach has been applied to enzyme inhibitors or receptor antagonists, to date it remains unprecedented for bifunctional molecules that bring proteins together, such as PROTAC degraders. Herein, we report the design and synthesis of a macrocyclic PROTAC by adding a cyclizing linker to the BET degrader MZ1. A co-crystal structure of macroPROTAC-1 bound in a ternary complex with VHL and the second bromodomain of Brd4 validated the rational design. Biophysical studies revealed enhanced discrimination between the second and the first bromodomains of BET proteins. Despite a 12-fold loss of binary binding affinity for Brd4, macroPROTAC-1 exhibited cellular activity comparable to MZ1. Our findings support macrocyclization as an advantageous strategy to enhance PROTAC degradation potency and selectivity between homologous targets.