Voltammetry of Organic Microparticles

 Solid microparticles of several different insoluble organic compounds were mechanically immobilized on the surface of graphite electrodes and immersed into a liquid electrolyte in order to study their electrochemical reactions. Cyclic staircase voltammetry and square-wave voltammetry were used. Quinhydrone was found to be a stable intermediate in the reversible redox reaction of solid quinone and hydroquinone on the electrode surface. The reaction occurs on the surface of the solid particle which is in contact with water. Indigo can be reduced to leucoindigo and oxidized to dehydroindigo in two separate reversible redox reactions. In strongly basic medium indigo dissolves in water upon electroreduction. A hydroacridine radical was detected as a stable intermediate in the electrochemically irreversible redox reaction of acridine and dihydroacridine. Famotidine can be electrooxidized and the product of this reaction can be electroreduced in two separate chemically irreversible reactions. Probucol is oxidized to a semiquinone radical which can be re-reduced in an electrochemically irreversible redox reaction. Propyl- thiouracil can be also oxidized to an unknown product which can be re-reduced in a chemically reversible, but slow solid state surface redox reaction. Reductions of solid thionicotinoylanilide and nicotinoylanilide are totally irreversible. Received September 22, 1998. Revision March 19, 1999.     

三氯化铁催化选择性合成普罗布考单丁二酸酯

研究了以三氯化铁为催化剂选择性合成普罗布考单丁二酸酯的反应.考察了催化剂、反应溶剂、碱、酰化剂及配料比对反应的影响.实验结果表明金属盐对反应的收率和单酰化反应的选择性有显著的影响,当以三氯化铁为催化剂,丁二酸酐为酰化剂,叔丁醇钠为碱,四氢呋喃为溶剂,普罗布考、叔丁醇钠、丁二酸酐及三氯化铁的摩尔比为1:4:5:0.17,...     

普罗布考联合阿托伐他汀对高脂血症患者血管内皮功能的影响

目的分析普罗布考联合阿托伐他汀对高脂血症患者血管内皮功能的影响。方法选取孝感仁信医院2014年3月—2016年3月收治的高脂血症患者88例,随机分为对照组(n=33)和观察组(n=55),对照组给予阿托伐他汀治疗,观察组给予普罗布考联合阿托伐他汀治疗,对比两组的血脂水平,并观察其对血管内皮功能的影响。结果治疗8周后,观察组HDL-C、NO高于对照组,TG、TC、LDL-C、ET-1低于对照组,差异具有统计学意义(P0.05);不良反应发生率组间比较差异无统计学意义(P0.05)。结论普罗布考联合阿托伐他汀可改善高脂血症患者的血脂水平,降低ET-1水平,提升HDL-C、NO含量,对血管内皮细胞具有良好的保护作用,具有较高的实用价值。