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Supriti Sen Snehasis Banerjee Susanta S. Adhikari Anuradha Moirangthem Anupam Basu 《合成通讯》2014,44(6):847-857
A systematic study of the reaction of 1,4-dihydrazinophthalazine (DHPH) with 1,3-dicarbonyls [viz., acetylacetone (acac), dibenzoylmethane (bzbz), and 1-benzoylacetone (bzac)] varying the reaction conditions was carried out to obtain the phthalazine derivatives (1–4). One-pot reaction of DHPH with acac led to the formation of two compounds 1 and 2, with various factors such as the presence of the acid or base, amount of the acac, time of reflux, and the temperature. The reaction conditions of DHPH with bzbz or bzac are sort of different to isolate the products 3 and 4, respectively. The derivatives (1–4) have been characterized by elemental analyses, 1H NMR, and electrospray ionization–mass spectrometry (ESIMS) and the cytotoxic activity of the compounds 1–4 was evaluated on HeLa cell line.
[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] 相似文献
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The novel three-component reaction of isoquinoline with isothiocyanates and isocyanides leads to a variety of new imidazoisoquinolines. The zwitterionic ground state of these new ring systems is established by means of NMR and X-ray analysis. Use of phthalazine instead of isoquinoline gives access to imidazole annulated phthalazines. 相似文献
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Kwok P. Chan Haixin Yang Allan S. Hay 《Journal of polymer science. Part A, Polymer chemistry》1996,34(10):1923-1931
Poly(aryl ether phthalazine)s were found to undergo an exothermic reaction at a temperature range of 360–440°C. We elucidated the origin of the exothermic reaction and the physiochemical phenomena associated with it, based on thermal analyses, model compound studies, and 13C solid-state NMR studies. At elevated temperatures, polymers containing a diphenylphthalazine moiety 4 underwent extensive thermal crosslinking reactions as a result of a nitrogen elimination reaction of the phthalazine moiety. However, polymers containing the tetraphenyl or hexaphenyl phthalazine moiety 5 and 6 were found to undergo principally a backbone rearrangement reaction, in which the phthalazine moiety rearranged to a quinazoline. Utilizing this efficient thermal rearrangement of polyphenylated phthalazines, we have prepared a novel activated difluoride, 2,4-bis(4-fluorophenyl)-,5,6,7,8-tetraphenylquinazoline 9d, which underwent high-temperature solution polycondensation with BPA to give the quinazoline containing poly(aryl ether) 14. Polymer 14 is amorphous, has a glass transition temperature of 264°C, and has high thermooxidative stability with 5% weight loss being recorded at 514°C in nitrogen. © 1996 John Wiley & Sons, Inc. 相似文献
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Satish Gudala Srinivasa Rao Ambati Archi Sharma Jeevan Lal Patel Rajeswar Rao Vedula Santhosh Penta 《中国化学会会志》2019,66(2):231-237
A series of novel, multifunctional 1,3,4‐thiadiazine derivatives bearing phthalazines, pyridazines and pyrido‐pyridazines ( 9–13 ) have been synthesized via the multicomponent reaction of (3‐(2‐bromo‐2‐[2‐chloropyrimidin‐4‐yl]acetyl)‐2‐chlorophenyl)‐2,6‐dichloro benzene‐sulfonamide with thiocarbohydrazide and various anhydrides. The reactions were performed by refluxing the components in mixed ethanol/acetic acid to afford the corresponding products in good to excellent yields. All the synthesized compounds were characterized by analytical and spectral studies. The developed method features short reaction time, simple work‐up without chromatographic separation, and a broad range of substrate applicability. 相似文献
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