全文获取类型
收费全文 | 1056篇 |
免费 | 116篇 |
国内免费 | 88篇 |
专业分类
化学 | 590篇 |
晶体学 | 7篇 |
力学 | 300篇 |
综合类 | 11篇 |
数学 | 43篇 |
物理学 | 309篇 |
出版年
2023年 | 2篇 |
2022年 | 24篇 |
2021年 | 28篇 |
2020年 | 30篇 |
2019年 | 17篇 |
2018年 | 28篇 |
2017年 | 27篇 |
2016年 | 36篇 |
2015年 | 33篇 |
2014年 | 41篇 |
2013年 | 53篇 |
2012年 | 54篇 |
2011年 | 50篇 |
2010年 | 51篇 |
2009年 | 67篇 |
2008年 | 79篇 |
2007年 | 66篇 |
2006年 | 78篇 |
2005年 | 47篇 |
2004年 | 58篇 |
2003年 | 42篇 |
2002年 | 36篇 |
2001年 | 20篇 |
2000年 | 38篇 |
1999年 | 30篇 |
1998年 | 27篇 |
1997年 | 22篇 |
1996年 | 23篇 |
1995年 | 26篇 |
1994年 | 31篇 |
1993年 | 36篇 |
1992年 | 11篇 |
1991年 | 7篇 |
1990年 | 4篇 |
1989年 | 8篇 |
1988年 | 9篇 |
1987年 | 10篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1978年 | 2篇 |
1959年 | 1篇 |
排序方式: 共有1260条查询结果,搜索用时 15 毫秒
1.
Enantiomeric Cyclic Peptides with Different Caco‐2 Permeability Suggest Carrier‐Mediated Transport
下载免费PDF全文
![点击此处可从《Chemistry (Weinheim an der Bergstrasse, Germany)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
B. Sc. Eduard Puig Prof. Dr. Beat Ernst Prof. Dr. Horst Kessler 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(22):8023-8027
Recently, oral absorption of cyclic hexapeptides was improved by N‐methylation of their backbone amides. However, the number and position of N‐methylations or of solvent exposed NHs did not correlate to intestinal permeability, measured in a Caco‐2 model. In this study, we investigate enantiomeric pairs of three polar and two lipophilic peptides to demonstrate the participation of carrier‐mediated transporters. As expected, all the enantiomeric peptides exhibited identical lipophilicity (logD7.4) and passive transcellular permeability determined by the parallel artificial membrane permeability assay (PAMPA). However, the enantiomeric polar peptides exhibited different Caco‐2 permeability (Papp) in both directions a–b and b–a. The same trend was observed for one of the lipophilic peptide, whereas the second lipophilic enantiomer pair showed identical Caco‐2 permeability (within the errors). These findings provide the first evidence for the involvement of carrier‐mediated transport for peptides, especially for those of polar nature. 相似文献
2.
采用交替沉积磁控溅射工艺制备了超薄多层的FeCoB SiO2 磁性纳米颗粒膜 .利用x射线衍射仪、扫描探针显微镜、透射电子显微镜分析了薄膜的微结构和形貌特征 .采用振动样品磁强计、四探针法、微波矢量分析仪及谐振腔法测量薄膜试样的磁电性能和微波复磁导率 .重点对SiO2 介质相含量、薄膜微结构对电磁性能产生重要影响的机理做了分析和探讨 .结果表明 :这类FeCoB SiO2 磁性纳米颗粒膜具有良好的软磁性能和高频电磁性能 ,2GHz时的磁导率 μ′高于 70 ,可以应用于高频微磁器件或微波吸收材料的设计 相似文献
3.
The steady-state two-phase flow non-linear equation is considered in the case when one of phases has low effective permeability in some periodic set, while on the complementary set it is high; the second phase has no contrast of permeabilities in different zones. A homogenization procedure gives the homogenized model with macroscopic effective permeability of the second phase depending on the gradient and on the second order derivatives of the macroscopic pressure of the first phase. This effect cannot be obtained by classical (one small parameter) homogenization. To cite this article: G.P. Panasenko, G. Virnovsky, C. R. Mecanique 331 (2003). 相似文献
4.
铸膜液的溶剂体系(溶剂和非溶剂)对不对称膜形态的形成有重要作用。为了探索溶剂和透气性间的关系,本文考虑到了制备BCA梯度密度不对称膜的各种溶剂的一系列物理参数,得到了一些定性结果,并指出了更全面、明确、解释两者关系的研究方向。 相似文献
5.
6.
Akira Shimazu Tukasa Miyazaki Shigeru Katayama Yasuo Ito 《Journal of Polymer Science.Polymer Physics》2003,41(3):308-318
The ortho‐positronium (o‐Ps) lifetime τ3 and its intensity I3 in various fluorinated polyimides were determined by the positron annihilation technique and were studied with the spin–lattice relaxation time T1 and the propylene permeability, solubility, diffusivity, and permselectivity for propylene/propane in them. τ3, I3, and the distribution of τ3 changed when the bulky moieties in the polyimides were changed. The polyimides, having both large τ3 and I3 values, exhibited a short T1 and a high permeability with a low permselectivity. The propylene permeability and diffusivity were exponentially correlated with the product of I3 and the average free‐volume hole size estimated from τ3. In highly plasticized states induced by the sorption of propylene, the permeability increased with the propylene pressure in excellent agreement with the change in the free‐volume hole properties probed by o‐Ps. The large and broad distribution of the free‐volume holes and increased local chain mobility for the 2,2‐bis(3,4‐decarboxyphenyl) hexafluoropropane dianhydride‐based polyimides are thought to be important physical properties for promoting penetrant‐induced plasticization. These results suggest that o‐Ps is a powerful probe of not only the free‐volume holes but also the corresponding permeation mechanism and penetrant‐induced plasticization phenomenon. © 2003 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 41: 308–318, 2003 相似文献
7.
This study describes the preparation of polyethersulfone (PES)/layered silicate nanocomposites (PLSNs) by mixing PES polymer chain into organically‐modified layered silicate in 1‐methyl‐2‐pyrrolidinone (NMP) solution. Both X‐ray diffraction data and transmission electron microscopy images of PLSNs indicate that the silicate layers were almost exfoliated and randomly distributed into the PES matrix. The mechanical and barrier properties of PLSNs show remarkable enhancement in the storage modulus and water/oxygen permeability when compared with that of neat PES matrix. Surfaces modification of PES and PLSN films with various treated times, system pressures, and radio frequency (RF) powers were performed using a mixture of oxygen (O2) and nitrogen (N2) plasmas. The topographical and physical properties of plasma‐modified PES and PLSN surfaces were investigated using scanning probe microscopy (SPM), contact‐angle measurements, and X‐ray photoelectron spectroscopy (XPS). These results indicate that the surface roughness of PLSNs with the same condition of plasma modification is lower than that of neat PES matrix and is probably due to the increase of stiffness with the presence of inorganic layered silicates in PES matrix. The surface properties of the PES and PLSNs are also changed from hydrophobic to hydrophilic. The XPS spectra suggest that the exposure of the PES and PLSNs to the plasmas led to the combination of etching reactions of polymer surface initiated by plasma and the following addition reactions of new oxygen‐ and nitrogen‐containing functional groups onto polymer surfaces to change their surface properties. © 2006 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 44: 3185–3194, 2006 相似文献
8.
J. Huňady M. ČerníkE.J. Hilinski M. PredmerskýA. Magurová 《Journal of magnetism and magnetic materials》2006
This paper discusses the influence of chemical composition on the final electromagnetic properties in higher permeability material. Furthermore, the effect of the hot rolling practice and the end of austenite transformation temperature range on the hot band microstructure is described. The magnetic polarization J5000 better than 1.7 T, using hot rolling conditions 40 mm transfer bar thickness, finish mill entry temperature 1000 °C, and finishing temperature 800–840 °C and after decarburization heat treatment and grain growth treatment, was obtained. 相似文献
9.
Both homogeneous and asymmetric polyethersulfone (PES) membranes were prepared by solvent casting. The sorption and permeation behavior of CO2, O2, and N2 using these two kinds of cast PES membranes and commercially available homogeneous PES film was investigated to extract the pressure dependence of gas permeability and the permselectivity for CO2 relative to N2, and to confirm the validity of the working assumption that a skin layer in an asymmetric membrane can be essentially replaced by a thick homogeneous dense membrane. The pressure dependence of the mean permeability coefficient to CO2 in homogeneous membranes obeys the dual-mode mobility model. The ideal separation factor for CO2 relative to N2 at an upstream pressure of 0.5 MPa attains ca. 40, while the permeability to CO2 is about 2.7 Barrer at the same upstream pressure. The same separation factor in asymmetric membranes amounts to 35. The diffusion behavior for the skin layer in an asymmetric membrane with a thin skin layer can be simulated approximately by that in a homogeneous dense membrane. © 1993 John Wiley & Sons, Inc. 相似文献
10.
P. M. Adler 《Transport in Porous Media》1988,3(2):185-198
The transversal Stokes flow of a Newtonian fluid through random and Sierpinski carpets is numerically calculated and the transversal permeability derived. In random carpets derived from site percolation, the average macroscopic permeability varies as (-
c)3/2, close to the critical porosity
c. This exponent is found to be slightly different from the conductivity exponent. Results for Sierpinski carpets are presented up to the fourth generation. The Carman equation is not verified in these two model porous media. 相似文献