一种多取代硝基环丙烷的开环反应研究

以一种多取代硝基环丙烷为底物,研究其在不同条件下的开环反应.以苄胺为亲核试剂时,底物发生开环生成烯胺化合物,对此反应机理进行了分析.研究了底物的还原开环反应：1）在Pd/C的催化氢化下,底物发生开环并消除硝基,得到烷基取代丙二酸二甲酯衍生物;2）在浓盐酸存在下用锌粉还原底物,得到五元环内酰胺.     

New spiro-fused 2-nitrocyclopropanecarboxylates: Synthesis and structure

Reactions of alkyl 3-bromo-3-nitroacrylates with cyclic CH-acids, Meldrum’s acid or 3-methyl-1-phenylpyrazol-5-one, afford new spiro-fused 2-nitrocyclopropanecarboxylates. In the case of Meldrum’s acid, the products are formed as individual diastereomers. The obtained experimental results are confirmed by quantum chemical calculations (B3LYP/6-311+G(d,p) taking into account solvent effects).